Aspergillus Thyroiditis after Allogeneic Hematopoietic Stem Cell Transplantation

Aspergillus thyroiditis is a rare disorder detected in immunocompromised patients during disseminated infections. Early management is essential to prevent high mortality. A 61-year-old allogeneic stem cell male recipient presented with painful thyroid nodular enlargement. He had low TSH and low free T4 levels. The thyroid ultrasound showed a hypoechoic nodule; biopsy indicated suppurative Aspergillus thyroiditis. He was successfully treated by amphotericin B.

[1]  E. Fliers,et al.  The molecular basis of the non-thyroidal illness syndrome. , 2015, The Journal of endocrinology.

[2]  M. Gilbert,et al.  Aspergillus Thyroiditis: A Complication of Respiratory Tract Infection in an Immunocompromised Patient , 2013, Case reports in endocrinology.

[3]  C. Minutti,et al.  Aspergillus thyroiditis: a review of the literature to highlight clinical challenges , 2012, European Journal of Clinical Microbiology & Infectious Diseases.

[4]  H. Erdem,et al.  Diffuse infiltration of Aspergillus hyphae in the thyroid gland with multinodular goiter. , 2011, Indian Journal of Pathology and Microbiology.

[5]  Y. Solak,et al.  Aspergillus thyroiditis in a renal transplant recipient mimicking subacute thyroiditis , 2011, Transplant infectious disease : an official journal of the Transplantation Society.

[6]  J. Franklyn,et al.  Acute bacterial suppurative thyroiditis: a clinical review and expert opinion. , 2010, Thyroid : official journal of the American Thyroid Association.

[7]  A. Maia,et al.  Fungal Thyroiditis: An Overview , 2006, Mycopathologia.

[8]  J. Donnelly,et al.  Detection of circulating galactomannan for the diagnosis and management of invasive aspergillosis. , 2004, The Lancet. Infectious diseases.

[9]  U. Machida,et al.  Clinical significance of extra-pulmonary involvement of invasive aspergillosis: a retrospective autopsy-based study of 107 patients. , 2002, The Journal of hospital infection.

[10]  M. Kami,et al.  Fatal Airway Obstruction Caused by Invasive Aspergillosis of the Thyroid Gland , 2002, Leukemia & lymphoma.

[11]  F. Derouin,et al.  Value of antigen detection using an enzyme immunoassay in the diagnosis and prediction of invasive aspergillosis in two adult and pediatric hematology units during a 4‐year prospective study , 2001, Cancer.

[12]  D. Feiglin,et al.  Invasive aspergillosis diagnosed by fine-needle aspiration of the thyroid gland. , 1999, Thyroid : official journal of the American Thyroid Association.

[13]  D. Denning,et al.  Antifungal and surgical treatment of invasive aspergillosis: review of 2,121 published cases. , 1990, Reviews of infectious diseases.

[14]  D. Allen,et al.  Thyroiditis , 1989, Clinical pediatrics.

[15]  구자홍,et al.  Aspergillosis , 2020, Red Book Atlas of Pediatric Infectious Diseases.

[16]  W. Marsden.  I and J , 2012 .

[17]  J. Lukens,et al.  Thyrotoxicosis associated with Aspergillus thyroiditis in chronic granulomatous disease. , 1972, The Journal of pediatrics.

[18]  J. Chrétien,et al.  [GENERALIZED ASPERGILLOSIS]. , 1963, La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris.