Seizure detection on/off system using rats' ECoG

We present an enhanced algorithm for seizure onset and offset detection in rats' ECoG. Because a seizure in rats' ECoG evolves much more stereotypically than that in human, analyzing seizure evolution in rats' ECoG is advantageous to understanding the evolution process. The proposed algorithm outperforms a prior automatic seizure detection and termination system in in-vivo rats' ECoG. We improve the algorithm by using relevant frequency bands of 14-22 Hz to onsets and 7-45Hz to offsets; by using spectral power rather than spectral amplitudes for its feature; and by replacing the 2-point moving-average filter for postprocessing with a 2nd order Kalman filter. Not only does the proposed algorithm provide better detection statistics, but it lowers the system's complexity by no longer requiring computation of a fast Fourier transform and by using a single structure with the two different spectral power features for onset and offset detection.

[1]  Keshab K. Parhi,et al.  Seizure Prediction With Spectral Power of EEG Using Cost-Sensitive Support Vector Machines , 2010 .

[2]  Brian Litt,et al.  Line length: an efficient feature for seizure onset detection , 2001, 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[3]  Brian Litt,et al.  One-Class Novelty Detection for Seizure Analysis from Intracranial EEG , 2006, J. Mach. Learn. Res..

[4]  S. Rothman,et al.  Optical suppression of experimental seizures in rat brain slices , 2010, Epilepsia.

[5]  S. Rothman,et al.  Neocortical Seizure Termination by Focal Cooling: Temperature Dependence and Automated Seizure Detection , 2002, Epilepsia.

[6]  T L Babb,et al.  Hippocampal EEG excitability and chronic spontaneous seizures are associated with aberrant synaptic reorganization in the rat intrahippocampal kainate model. , 1993, Electroencephalography and clinical neurophysiology.

[7]  S. Rothman,et al.  Focal cooling rapidly terminates experimental neocortical seizures , 2001, Annals of neurology.

[8]  F. Mormann,et al.  Seizure prediction: the long and winding road. , 2007, Brain : a journal of neurology.

[9]  R. Esteller,et al.  Comparison of line length feature before and after brain electrical stimulation in epileptic patients , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.