Canonical and noncanonical functions of ULK/Atg1.
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Mondira Kundu | Bo Wang | M. Kundu | Bo Wang
[1] A Kihara,et al. Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion. , 2001, Molecular biology of the cell.
[2] T. P. Neufeld,et al. ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase , 2013, Nature Cell Biology.
[3] C. Jung,et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. , 2009, Molecular biology of the cell.
[4] B. Viollet,et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 , 2011, Nature Cell Biology.
[5] Z. Ye,et al. ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy. , 2016, Molecular cell.
[6] Wenxian Wu,et al. Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy , 2015, FEBS letters.
[7] Sheila M. Thomas,et al. AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization , 2012, Autophagy.
[8] M. Colombo,et al. Autophagosome Formation Depends on the Small GTPase Rab1 and Functional ER Exit Sites , 2010, Traffic.
[9] D. Klionsky,et al. Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway , 1995, The Journal of cell biology.
[10] Hideyuki Okano,et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice , 2006, Nature.
[11] N. Belogortseva,et al. Regulation of selective autophagy onset by a Ypt/Rab GTPase module , 2012, Proceedings of the National Academy of Sciences.
[12] E. Suzuki,et al. UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly. , 2008, Genes & development.
[13] S. Wesselborg,et al. Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks , 2011, Molecular and Cellular Biology.
[14] J. Lippincott-Schwartz,et al. Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes , 2006, Journal of Cell Science.
[15] She Chen,et al. ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy* , 2009, Journal of Biological Chemistry.
[16] Y. Goshima,et al. The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans , 2006, Development.
[17] M. L. Lachenmayer,et al. Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates , 2015, PLoS genetics.
[18] X. Wang,et al. Intensive expression of UNC‐51‐like kinase 1 is a novel biomarker of poor prognosis in patients with esophageal squamous cell carcinoma , 2011, Cancer science.
[19] D. Klionsky,et al. The machinery of macroautophagy , 2013, Cell Research.
[20] Ruedi Aebersold,et al. Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 Kinase , 2014, Molecular cell.
[21] D. Bernlohr,et al. Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes , 2013, Autophagy.
[22] Y. Ohsumi,et al. Hrr25 triggers selective autophagy–related pathways by phosphorylating receptor proteins , 2014, The Journal of cell biology.
[23] Z. Elazar,et al. LC3 and GATE‐16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis , 2010, The EMBO journal.
[24] I. Ganley,et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. , 2015, The Journal of Biological Chemistry.
[25] Qinxi Li,et al. GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy , 2012, Science.
[26] J. Guan,et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. , 2009, Molecular biology of the cell.
[27] Y. Fujioka,et al. Atg1 family kinases in autophagy initiation , 2015, Cellular and Molecular Life Sciences.
[28] E. White,et al. Recent insights into the function of autophagy in cancer , 2016, Genes & development.
[29] A. Sidow,et al. Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. , 2013, Genes & development.
[30] M. Hatten,et al. A Mouse Serine/Threonine Kinase Homologous to C. elegans UNC51 Functions in Parallel Fiber Formation of Cerebellar Granule Neurons , 1999, Neuron.
[31] Quan Chen,et al. Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy , 2016, Cell Research.
[32] T. Tomoda,et al. Unc-51/ATG1 Controls Axonal and Dendritic Development via Kinesin-Mediated Vesicle Transport in the Drosophila Brain , 2011, PloS one.
[33] T. Oliver,et al. Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons , 2007, Proceedings of the National Academy of Sciences.
[34] B. Viollet,et al. Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy , 2011, Science.
[35] Masaaki Komatsu,et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice , 2006, Nature.
[36] R. Olsen,et al. The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[37] I. Mori,et al. Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase. , 1994, Genes & development.
[38] G. Barber,et al. Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling , 2013, Cell.
[39] Kazuya Nagano,et al. Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex , 2000, The Journal of cell biology.
[40] D. Green,et al. The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis. , 2016, Molecular cell.
[41] K. Shah,et al. An Atg13 Protein-mediated Self-association of the Atg1 Protein Kinase Is Important for the Induction of Autophagy* , 2011, The Journal of Biological Chemistry.
[42] Y. Masuho,et al. Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. , 2000, Brain research. Molecular brain research.
[43] John M Asara,et al. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. , 2015, Molecular cell.
[44] D. Voytas,et al. The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14 , 2016, Autophagy.
[45] Hong-gang Yu,et al. UNC51-like kinase 1 as a potential prognostic biomarker for hepatocellular carcinoma. , 2013, International journal of clinical and experimental pathology.
[46] N. Jafari,et al. Central role of ULK1 in type I interferon signaling. , 2015, Cell reports.
[47] Z. Yue,et al. ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models , 2016, Molecular Neurodegeneration.
[48] Kay Hofmann,et al. Binding of the Atg1/ULK1 kinase to the ubiquitin‐like protein Atg8 regulates autophagy , 2012, The EMBO journal.
[49] A. Porat,et al. GATE‐16, a membrane transport modulator, interacts with NSF and the Golgi v‐SNARE GOS‐28 , 2000, The EMBO journal.
[50] A. Shelat,et al. Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1 , 2015, Cell Death and Differentiation.
[51] Yayoi Kimura,et al. Structural basis of starvation-induced assembly of the autophagy initiation complex , 2014, Nature Structural &Molecular Biology.
[52] Xuejun Jiang,et al. The ULK1 complex , 2013, Autophagy.
[53] M. Hatten,et al. Role of Unc51.1 and its binding partners in CNS axon outgrowth. , 2004, Genes & development.
[54] N. Mizushima,et al. The role of the Atg1/ULK1 complex in autophagy regulation. , 2010, Current opinion in cell biology.
[55] William C Mobley,et al. Signaling endosome hypothesis: A cellular mechanism for long distance communication. , 2004, Journal of neurobiology.
[56] M. Karin,et al. Immunity, Inflammation, and Cancer , 2010, Cell.
[57] G. Garriga,et al. The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans , 2004, Development.
[58] Hong Zhang,et al. epg-1 functions in autophagy-regulated processes and may encode a highly divergent Atg13 homolog in C. elegans , 2009, Autophagy.
[59] C. Kraft,et al. Two Independent Pathways within Selective Autophagy Converge to Activate Atg1 Kinase at the Vacuole. , 2016, Molecular cell.
[60] C. Thompson,et al. Ammonia-induced autophagy is independent of ULK1/ULK2 kinases , 2011, Proceedings of the National Academy of Sciences.
[61] P. Chakravarty,et al. Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130 , 2015, Molecular cell.
[62] Y. Ohsumi,et al. Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae , 2013, Journal of Cell Science.
[63] Gustav Ammerer,et al. Activation of Atg1 kinase in autophagy by regulated phosphorylation , 2010, Autophagy.
[64] L. Attardi,et al. TRP53 activates a global autophagy program to promote tumor suppression , 2013, Autophagy.
[65] R. Schekman,et al. Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment , 2014, eLife.
[66] M. Babu,et al. ER exit sites are physical and functional core autophagosome biogenesis components , 2013, Molecular biology of the cell.
[67] X. Wang,et al. Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death , 2011, Cell Death and Differentiation.
[68] L. Collinson,et al. Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles , 2016, Nature Communications.
[69] D. Rubinsztein,et al. Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes , 2013, Cell.
[70] Y. Ohshima,et al. The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine/threonine kinase UNC-51. , 1997, Genes & development.
[71] M. Schaller,et al. Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction , 2011, Autophagy.
[72] Jian-Hua Fu,et al. Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients , 2012, Breast Cancer Research and Treatment.
[73] Hong Zhang,et al. The C. elegans ATG101 homolog EPG-9 directly interacts with EPG-1/Atg13 and is essential for autophagy , 2012, Autophagy.
[74] W. Mobley,et al. NGF Signaling in Sensory Neurons Evidence that Early Endosomes Carry NGF Retrograde Signals , 2003, Neuron.
[75] S. J. Deminoff,et al. The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy , 2009, Proceedings of the National Academy of Sciences.
[76] F. W. Wolf,et al. C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations , 2007, Nature Neuroscience.
[77] N. Brandon,et al. GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton , 1999, Nature.
[78] C. Liang,et al. Neural-specific Deletion of FIP200 Leads to Cerebellar Degeneration Caused by Increased Neuronal Death and Axon Degeneration* , 2009, The Journal of Biological Chemistry.
[79] D. Klionsky,et al. The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. , 2004, Developmental cell.
[80] J. Nunnari,et al. Mitochondria regulate autophagy by conserved signalling pathways , 2011, The EMBO journal.
[81] Daniel J. Klionsky,et al. Autophagy fights disease through cellular self-digestion , 2008, Nature.
[82] Jian-Hua Fu,et al. Erratum to: Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients , 2012, Breast Cancer Research and Treatment.
[83] A. Harris,et al. Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival. , 2013, The Biochemical journal.
[84] R. Olsen,et al. GABAA Receptor-Associated Protein Traffics GABAA Receptors to the Plasma Membrane in Neurons , 2004, The Journal of Neuroscience.