Stereospecific high-performance liquid chromatographic analysis of tramadol and its O-demethylated (M1) and N,O-demethylated (M5) metabolites in human plasma.

[1]  K. Brøsen,et al.  Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers , 2006, European Journal of Clinical Pharmacology.

[2]  M. A. Campanero,et al.  Simultaneous stereoselective analysis of tramadol and its primary phase I metabolites in plasma by liquid chromatography. Application to a pharmacokinetic study in humans. , 2004, Journal of chromatography. A.

[3]  B. Streel,et al.  Pharmacokinetic evaluation of a new oral sustained release dosage form of tramadol. , 2003, British journal of clinical pharmacology.

[4]  Thomas Layloff,et al.  Analytical Methods Validation: Bioavailability, Bioequivalence and Pharmacokinetic Studies , 1992, Pharmaceutical Research.

[5]  I. Trocóniz,et al.  Pharmacokinetic/Pharmacodynamic Modeling of the Antinociceptive Effects of (+)-Tramadol in the Rat: Role of Cytochrome P450 2D Activity , 2003, Journal of Pharmacology and Experimental Therapeutics.

[6]  F. Nielsen,et al.  Enantioselective HPLC method for quantitative determination of tramadol andO-desmethyltramadol in plasma and urine: Application to clinical studies , 2003 .

[7]  M. Nobilis,et al.  High-performance liquid chromatographic determination of tramadol and its O-desmethylated metabolite in blood plasma. Application to a bioequivalence study in humans. , 2002, Journal of chromatography. A.

[8]  W. Wu,et al.  Metabolism of the analgesic drug ULTRAM ® (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites , 2002, Xenobiotica; the fate of foreign compounds in biological systems.

[9]  S. Gan,et al.  Validation of a high-performance liquid chromatography method for tramadol and o-desmethyltramadol in human plasma using solid-phase extraction. , 2001, Journal of chromatography. B, Biomedical sciences and applications.

[10]  Y. Hou,et al.  Pharmacokinetics of enantiomers of trans-tramadol and its active metabolite, trans-O-demethyltramadol, in human subjects. , 2001, Acta Pharmacologica Sinica.

[11]  A. Ceccato,et al.  Enantiomeric determination of tramadol and its main metabolite O-desmethyltramadol in human plasma by liquid chromatography-tandem mass spectrometry. , 2000, Journal of chromatography. B, Biomedical sciences and applications.

[12]  I. Trocóniz,et al.  Modeling of the in vivo antinociceptive interaction between an opioid agonist, (+)-O-desmethyltramadol, and a monoamine reuptake inhibitor, (-)-O-desmethyltramadol, in rats. , 2000, The Journal of pharmacology and experimental therapeutics.

[13]  C. Gillen,et al.  Affinity, potency and efficacy of tramadol and its metabolites at the cloned human µ-opioid receptor , 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

[14]  R. Calvo,et al.  Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effects of main active metabolites of tramadol, (+)-O-desmethyltramadol and (-)-O-desmethyltramadol, in rats. , 2000, The Journal of pharmacology and experimental therapeutics.

[15]  S. Fanali,et al.  Simultaneous stereoselective analysis of tramadol and its main phase I metabolites by on-line capillary zone electrophoresis-electrospray ionization mass spectrometry. , 2000, Journal of chromatography. A.

[16]  T. Meuser,et al.  Serum concentrations of tramadol enantiomers during patient-controlled analgesia. , 1999, British journal of clinical pharmacology.

[17]  S. Fanali,et al.  Simultaneous stereoselective analysis by capillary electrophoresis of tramadol enantiomers and their main phase I metabolites in urine. , 1999, Journal of chromatography. A.

[18]  R. Calvo,et al.  Simultaneous determination of tramadol and its major active metabolite O-demethyltramadol by high-performance liquid chromatography with electrochemical detection. , 1999, Journal of chromatography. B, Biomedical sciences and applications.

[19]  M. A. Campanero,et al.  Enantiomeric separation of tramadol and its active metabolite in human plasma by chiral high-performance liquid chromatography: application to pharmacokinetic studies. , 1999, Chirality.

[20]  P. Chiap,et al.  Automated determination of tramadol enantiomers in human plasma using solid-phase extraction in combination with chiral liquid chromatography. , 1997, Journal of chromatography. B, Biomedical sciences and applications.

[21]  L. Arendt-Nielsen,et al.  The hypoalgesic effect of tramadol in relation to CYP2D6 * , 1996, Clinical pharmacology and therapeutics.

[22]  R. Shank,et al.  Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. , 1993, The Journal of pharmacology and experimental therapeutics.

[23]  G. Blaschke,et al.  Achiral and chiral high-performance liquid chromatographic determination of tramadol and its major metabolites in urine after oral administration of racemic tramadol. , 1993, Journal of chromatography.

[24]  E. Frankus,et al.  [Biotransformation of tramadol in man and animal (author's transl)]. , 1981, Arzneimittel-Forschung.