Inhibitory effects of epicatechin on interleukin-1beta-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation.

[1]  Y. Kotake,et al.  Free radicals and the pathogenesis of type 1 diabetes: beta-cell cytokine-mediated free radical generation via cyclooxygenase-2. , 2003, Diabetes.

[2]  D. Min,et al.  Protective Effects of Epicatechin Against the Toxic Effects of Streptozotocin on Rat Pancreatic Islets: In Vivo and in Vitro , 2003, Pancreas.

[3]  M. Kruhøffer,et al.  A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells* , 2001, The Journal of Biological Chemistry.

[4]  D. Rhie,et al.  Effect of Somatostatin on Cholecystokinin-Induced Amylase Release in Rat Pancreatic Acini , 2001, Pancreas.

[5]  D. Min,et al.  Distributional Patterns of Phospholipase C Isozymes in Rat Pancreas , 2001, Pancreas.

[6]  Y. Kotake,et al.  Inhibition of the cytokine-mediated inducible nitric oxide synthase expression in rat insulinoma cells by phenyl N-tert-butylnitrone. , 2000, Nitric oxide : biology and chemistry.

[7]  E. Ho,et al.  Antioxidants, NFκB Activation, and Diabetogenesis , 1999 .

[8]  M. Karin.  How NF-κB is activated: the role of the IκB kinase (IKK) complex , 1999, Oncogene.

[9]  M. Mayo,et al.  Interleukin-10 Signaling Blocks Inhibitor of κB Kinase Activity and Nuclear Factor κB DNA Binding* , 1999, The Journal of Biological Chemistry.

[10]  J. Koistinaho,et al.  Molecular cloning and characterization of the rat inducible nitric oxide synthase (iNOS) gene. , 1999, Gene.

[11]  P. Flatt,et al.  Physiological and pharmacological regulation of insulin release: insights offered through exploitation of insulin‐secreting cell lines , 1999, Diabetes, obesity & metabolism.

[12]  S. Gupta,et al.  Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Meirong Xu,et al.  Cancer Chemopreventive Mechanisms of Tea Against Heterocyclic Amine Mutagens from Cooked Meat , 1999, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[14]  C. Brinckerhoff,et al.  Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts. , 1998, Arthritis and rheumatism.

[15]  M. Su,et al.  Interleukin-1β-induced Rat Pancreatic Islet Nitric Oxide Synthesis Requires Both the p38 and Extracellular Signal-regulated Kinase 1/2 Mitogen-activated Protein Kinases* , 1998, The Journal of Biological Chemistry.

[16]  W. Suarez-Pinzon,et al.  Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. , 1998, Biochemical pharmacology.

[17]  M. Mcdaniel,et al.  Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. , 1998, Diabetes.

[18]  J. Corbett,et al.  Irreversible Inhibition of Metabolic Function and Islet Destruction after a 36-Hour Exposure to Interleukin-1β. , 1997, Endocrinology.

[19]  Jen-kun Lin,et al.  (−)-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor-κB , 1997 .

[20]  M. Mcdaniel,et al.  Effects of aspirin on nitric oxide formation and de novo protein synthesis by RINm5F cells and rat islets. , 1997, Molecular pharmacology.

[21]  S. Lenzen,et al.  Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells , 1997, Diabetes.

[22]  N. Welsh,et al.  The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells , 1996, Diabetologia.

[23]  C. Benoist,et al.  Checkpoints in the progression of autoimmune disease: lessons from diabetes models. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[24]  M. Mcdaniel,et al.  Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism. , 1995, Endocrinology.

[25]  S. Virtanen,et al.  Nitrate and Nitrite Intake and the Risk for Type 1 Diabetes in Finnish Children , 1994 .

[26]  C. Nathan,et al.  Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. , 1994, The Journal of biological chemistry.

[27]  N. Welsh,et al.  Interleukin‐1 ‐induced expression of nitric oxide synthase in insulin‐producing cells is preceded by c‐fos induction and depends on gene transcription and protein synthesis , 1993, FEBS letters.

[28]  M. Rewers,et al.  Nitrate Levels in Community Drinking Waters and Risk of IDDM: An ecological analysis , 1992, Diabetes Care.

[29]  B. Wolf,et al.  Nitric oxide and cyclic GMP formation induced by interleukin 1 beta in islets of Langerhans. Evidence for an effector role of nitric oxide in islet dysfunction. , 1992, The Biochemical journal.

[30]  I. Green,et al.  Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanism , 1990 .

[31]  S. Howell,et al.  Assessment of the antidiabetic activity of epicatechin in streptozotocin-diabetic and spontaneously diabetic BB/E rats , 1985, Bioscience reports.

[32]  S. Howell,et al.  Effects of Epicatechin on Rat Islets of Langerhans , 1984, Diabetes.

[33]  R. Roeder,et al.  Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. , 1983, Nucleic acids research.

[34]  P. Schiff,et al.  A constituent of Pterocarpus marsupium, (-)-epicatechin, as a potential antidiabetic agent. , 1983, Journal of natural products.

[35]  S. Gupta,et al.  Functional beta cell regeneration in the islets of pancreas in alloxan induced diabetic rats by (-)-epicatechin. , 1982, Life sciences.

[36]  D. Min,et al.  Site-Specific Distribution of Phospholipase D Isoforms in the Rat Pancreas , 2003 .

[37]  S. Lenzen,et al.  Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. , 1996, Free radical biology & medicine.

[38]  S. Snyder,et al.  Nitric oxide: a physiologic messenger molecule. , 1994, Annual review of biochemistry.

[39]  N. Welsh,et al.  Biochemical and Molecular Actions of Interleukin-1 on Pancreatic β-Cells , 1991 .