Pilot study of modified LMB‐based therapy for children with ataxia–telangiectasia and advanced stage high grade mature B‐cell malignancies

Children with ataxia–telangiectasia (A–T) and cancer have a poorer prognosis due in part to increased treatment‐related toxicity. We piloted a curative intent approach in five children with A–T who presented with advanced stage (III, n = 2; IV, n = 3) B‐NHL (diffuse large B‐cell lymphoma, n = 4; Burkitt leukemia, n = 1) using a modified LMB‐based protocol. Two achieved sustained CCR (one, CCR at 6 years; one, pulmonary death after 3 years in CCR). Two died from toxicity during induction and 1 failed induction with progressive disease. Novel therapeutic approaches which overcome drug resistance and are less toxic are needed for children with A–T and B‐NHL. Pediatr Blood Cancer 2014;61:360–362. © 2013 Wiley Periodicals, Inc.

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