Differential toxicity of aflatoxin B1 in male and female rats: relationship with hepatic drug-metabolizing enzymes.

[1]  K. Bock,et al.  Release of mutagenic metabolites of benzo[a]pyrene from the perfused rat liver after inhibition of glucuronidation and sulfation by salicylamide. , 1981, Chemico-biological interactions.

[2]  G. Siest,et al.  Effect of aflatoxin B1 on hepatic drug-metabolizing enzymes in female rats. Interaction with a contraceptive agent. , 1981, Xenobiotica; the fate of foreign compounds in biological systems.

[3]  T. C. Campbell,et al.  Effect of sex differences on subcellular distribution of aflatoxin in F-344 rats treated with various risk-modifying factors. , 1981, Toxicology and applied pharmacology.

[4]  S. Stohs,et al.  Effect of hypophysectomy and castration on hepatic, pulmonary and intestinal aryl hydrocarbon hydroxylase activities in the rat. , 1981, The Journal of pharmacology and experimental therapeutics.

[5]  C. Schlatter,et al.  In vivo covalent binding of aflatoxin B1 and aflatoxin M1 to liver DNA of rat, mouse and pig. , 1980, Chemico-biological interactions.

[6]  G. Siest,et al.  gamma-Glutamyltransferase of rabbit liver: Kinetic study of phenobarbital induction and in vitro solubilization by bile salts. , 1980, Toxicology and applied pharmacology.

[7]  M. Kao,et al.  Sequential biochemical and histological changes in rats treated with aflatoxin B1. , 1980, British Journal of Cancer.

[8]  H. Gurtoo,et al.  Effects of inducers and inhibitors on the metabolism of aflatoxin B1 by rat and mouse. , 1979, Biochemical pharmacology.

[9]  D. Jerina,et al.  Continous fluorometric assay of epoxide hydrase activity. , 1979, Analytical biochemistry.

[10]  H. Neumann,et al.  The major metabolite of aflatoxin B1 in the rat is a glutathione conjugate. , 1978, Chemico-biological interactions.

[11]  G. Wishart,et al.  Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticoids. Demonstration of two groups within the enzyme's activity towards twelve substrates. , 1978, The Biochemical journal.

[12]  D. Breimer,et al.  The influence of phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on glutathione S-transferase activity of rat liver cytosol. , 1978, Biochemical pharmacology.

[13]  J. Miller,et al.  2,3-Dihydro-2-(guan-7-yl)-3-hydroxy-aflatoxin B1, a major acid hydrolysis product of aflatoxin B1-DNA or -ribosomal RNA adducts formed in hepatic microsome-mediated reactions and in rat liver in vivo. , 1977, Cancer research.

[14]  H. Gurtoo,et al.  Effect of sex difference on the in vitro and in vivo metabolism of aflatoxin B1 by the rat. , 1976, Cancer research.

[15]  G. Mulder,et al.  A rapid NAD+-linked assay for microsomal uridine diphosphate glucuronyltransferase of rat liver and some observations on substrate specificity of the enzyme. , 1975, The Biochemical journal.

[16]  V. Desmet,et al.  Histochemistry of gamma-glutamyl transpeptidase in rat liver during aflatoxin B1-induced carcinogenesis. , 1975, Journal of the National Cancer Institute.

[17]  J. Miller,et al.  Aflatoxin B1-2,3-oxide: evidence for its formation in rat liver in vivo and by human liver microsomes in vitro. , 1974, Biochemical and biophysical research communications.

[18]  D. Jerina,et al.  Arene oxides: a new aspect of drug metabolism. , 1974, Science.

[19]  T. Bever,et al.  Cerebral Dominance in Musicians and Nonmusicians , 1974, Science.

[20]  R. Garner Microsome-dependent binding of aflatoxin B1 to DNA, RNA, polyribonucleotides and protein in vitro. , 1973, Chemico-biological interactions.

[21]  J. Miller,et al.  Liver microsomal metabolism of aflatoxin B 1 to a reactive derivative toxic to Salmonella typhimurium TA 1530. , 1972, Cancer research.

[22]  W. Shalkop,et al.  Influence of age and sexual status on the development of toxic effects in the male rat fed aflatoxins. , 1972, Toxicology and applied pharmacology.

[23]  R. C. Shank,et al.  Dietary aflatoxins and human liver cancer. IV. Incidence of primary liver cancer in two municipal populations of Thailand. , 1972, Food and cosmetics toxicology.

[24]  R. C. Shank,et al.  Dietary aflatoxins and human liver cancer. V. Duration of primary liver cancer and prevalence of hepatomegaly in Thailand. , 1972, Food and cosmetics toxicology.

[25]  G. Wogan,et al.  Structure-activity relationships in toxicity and carcinogenicity of aflatoxins and analogs. , 1971, Cancer research.

[26]  C S Davidson,et al.  Association between aflatoxin content of food and hepatoma frequency in Uganda , 1971, Cancer.

[27]  W. H. Butler,et al.  Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals: a review. , 1969, Cancer research.

[28]  W. H. Butler,et al.  Carcinogenic action of groundnut meal containing aflatoxin in rats. , 1968, Food and cosmetics toxicology.

[29]  Wogan Gn,et al.  Dose-response characteristics of aflatoxin B1 carcinogenesis in the rat. , 1967 .

[30]  I. Purchase Acute toxicity of aflatoxins M1 and M2 in one-day-old ducklings. , 1967, Food and cosmetics toxicology.

[31]  S. Gambino,et al.  The measurement of amniotic fluid bilirubin by the method of Jendrassik and Gróf. Its correlation with spectrophotometric analysis. , 1966, American journal of clinical pathology.

[32]  G. Frontino,et al.  Influence of sex difference on the pharmacological action and metabolism of some drugs. , 1961, Biochemical pharmacology.

[33]  B. Brodie,et al.  Species, strain and sex differences in metabolism of hexobarbitone, amidopyrine, antipyrine and aniline , 1958 .

[34]  G. H. Hogeboom [3] Fractionation of cell components of animal tissues , 1955 .

[35]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.