Highly Diastereoselective Syntheses of Spiro‐Oxindole Dihydrofuran Derivatives in Aqueous Media and Their Antibacterial Activity

[1]  S. Y. Kim,et al.  An efficient synthesis of dihydrofuranyl spirooxindoles from isatin-derived propargylic alcohols and 1,3-dicarbonyls , 2017 .

[2]  R. Mehrotra,et al.  Spiro-oxindoles as a Promising Class of Small Molecule Inhibitors of p53–MDM2 Interaction Useful in Targeted Cancer Therapy , 2017, Topics in Current Chemistry.

[3]  V. Kesavan,et al.  Stereoselective and Regioselective Assembly of Spirooxindole [2,1‐b]furan Motifs through a Tandem Friedel–Crafts Alkylation/5‐exo‐dig‐Cyclization , 2016 .

[4]  J. Ryu,et al.  One-pot synthesis of 3-naphtho[2,1-b]furanyl-2-oxindoles from 3-(arylethynyl)-3-hydroxyindolin-2-ones and 2-naphthols , 2016 .

[5]  A. Prince,et al.  Gold catalyzed double condensation reaction: Synthesis, antimicrobial and cytotoxicity of spirooxindole derivatives. , 2016, Bioorganic & medicinal chemistry letters.

[6]  Kesavan Venkitasamy,et al.  Stereo and Regioselective Assembly of Spirooxindole [2,1‐b]furan Motifs via Tandem Friedel‐Craft Alkylation/5‐exo‐dig‐Cyclization , 2016 .

[7]  Na Ye,et al.  Therapeutic Potential of Spirooxindoles as Antiviral Agents. , 2016, ACS infectious diseases.

[8]  Jia Li,et al.  Diastereoselective Three-Component Cascade Reaction to Construct Oxindole-Fused Spirotetrahydro­furochroman Scaffolds for Drug Discovery , 2016 .

[9]  D. Du,et al.  Organocatalytic cascade Michael/Michael reaction for the asymmetric synthesis of spirooxindoles containing five contiguous stereocenters. , 2016, Chemical communications.

[10]  Shengzheng Wang,et al.  Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3'-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors. , 2016, Organic letters.

[11]  P. Yogeeswari,et al.  Synthesis of new spirooxindole derivatives through 1,3-dipolar cycloaddition of azomethine ylides and their antitubercular activity , 2016 .

[12]  V. Lipson,et al.  Molecular diversity of spirooxindoles. Synthesis and biological activity , 2015, Molecular Diversity.

[13]  Ruifeng Li,et al.  P(NMe2)3-mediated reductive [1+4] annulation of isatins with enones: a facile synthesis of spirooxindole-dihydrofurans. , 2015, Chemical communications.

[14]  Junbiao Chang,et al.  A New Strategy for Enantioselective Construction of Multisubstituted Five-Membered Oxygen Heterocycles via a Domino Michael/Hemiketalization Reaction. , 2015, Chemistry.

[15]  Hong-min Liu,et al.  Spirooxindoles: Promising scaffolds for anticancer agents. , 2015, European journal of medicinal chemistry.

[16]  Jian-Wu Xie,et al.  Synthesis and antifungal activities of novel polyheterocyclic spirooxindole derivatives. , 2015, Organic & biomolecular chemistry.

[17]  M. Knorr,et al.  A strategic approach to the synthesis of functionalized spirooxindole pyrrolidine derivatives: in vitro antibacterial, antifungal, antimalarial and antitubercular studies , 2015 .

[18]  Maria M. M. Santos.  Recent advances in the synthesis of biologically active spirooxindoles , 2014 .

[19]  Suresh B. Singh,et al.  The use of spirocyclic scaffolds in drug discovery. , 2014, Bioorganic & medicinal chemistry letters.

[20]  M. Shi,et al.  Phosphine-catalyzed asymmetric [4+1] annulation of activated α,β-unsaturated ketones with Morita-Baylis-Hillman carbonates: enantioselective synthesis of spirooxindoles containing two adjacent quaternary stereocenters. , 2014, Chemical communications.

[21]  M. Xia,et al.  Recent Progress on Routes to Spirooxindole Systems Derived from Isatin , 2014 .

[22]  C. Barbas,et al.  Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies , 2014 .

[23]  Jian Zhou,et al.  One-pot tandem approach to spirocyclic oxindoles featuring adjacent spiro-stereocenters. , 2013, Angewandte Chemie.

[24]  B. Trost,et al.  Rapid access to spirocyclic oxindole alkaloids: application of the asymmetric palladium-catalyzed [3 + 2] trimethylenemethane cycloaddition. , 2013, Journal of the American Chemical Society.

[25]  R. Sarpong,et al.  Synthetic studies toward the citrinadin A and B core architecture. , 2013, Organic letters.

[26]  S. Martin,et al.  Enantioselective total synthesis of (-)-citrinadin A and revision of its stereochemical structure. , 2013, Journal of the American Chemical Society.

[27]  M. Shi,et al.  Diastereo- and Enantioselective Construction of Oxindole-Fused Spirotetrahydrofuran Scaffolds through Palladium-Catalyzed Asymmetric [3+2] Cycloaddition of Vinyl Cyclopropanes and Isatins , 2013 .

[28]  B. Alcaide,et al.  Metal-catalyzed rearrangements of 3-allenyl 3-hydroxyindolin-2-ones in the presence of halogenated reagents. , 2013, Organic & biomolecular chemistry.

[29]  G. S. Singh,et al.  Isatins as privileged molecules in design and synthesis of spiro-fused cyclic frameworks. , 2012, Chemical reviews.

[30]  A. Franz,et al.  Strategies for the enantioselective synthesis of spirooxindoles. , 2012, Organic & biomolecular chemistry.

[31]  N. Foroughifar,et al.  Simple and Efficient Method for Three-Component Synthesis of Spirooxindoles in Aqueous and Solvent-Free Media , 2011 .

[32]  Herbert Waldmann,et al.  Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products , 2010, Nature Chemistry.

[33]  Trixie Wagner,et al.  Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria , 2010, Journal of medicinal chemistry.

[34]  B. Trost,et al.  Asymmetric Syntheses of Oxindoleand Indole Spirocyclic Alkaloid Natural Products , 2009 .

[35]  P. Galletti,et al.  Solvent effects on stereoselectivity: more than just an environment. , 2009, Chemical Society reviews.

[36]  J. Prunet,et al.  Dramatic solvent effect on the diastereoselectivity of Michael addition: study toward the synthesis of the ABC ring system of hexacyclinic acid. , 2008, Organic letters.

[37]  K. Scheidt,et al.  Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents. , 2007, Angewandte Chemie.

[38]  P. T. Perumal,et al.  An efficient one-pot synthesis of spiro dihydrofuran fluorene and spiro 2-hydroxytetrahydrofuran fluorene derivatives via [3+2] oxidative cycloaddition mediated by CAN , 2007 .

[39]  S. Hisaindee,et al.  A Heterodinuclear Asymmetric Catalyst for Conjugate Additions of α-Hydroxyketones to β-Substituted Nitroalkenes , 2006 .

[40]  Su Qiu,et al.  Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. , 2006, Journal of medicinal chemistry.

[41]  M. Tsuda,et al.  Absolute stereochemistry of citrinadins a and B from marine-derived fungus. , 2005, The Journal of organic chemistry.

[42]  M. Nethaji,et al.  Multicomponent reactions of diazoamides: diastereoselective synthesis of mono- and bis-spirofurooxindoles. , 2004, The Journal of organic chemistry.

[43]  A. A. Raj,et al.  Synthesis, antimicrobial and antifungal activity of a new class of spiro pyrrolidines. , 2003, Bioorganic & medicinal chemistry.

[44]  S. Matsunaga,et al.  Direct catalytic asymmetric Michael reaction of hydroxyketones: asymmetric Zn catalysis with a Et2Zn/linked-BINOL complex. , 2003, Journal of the American Chemical Society.

[45]  Robert M. Williams,et al.  Paraherquamides, brevianamides, and asperparalines: laboratory synthesis and biosynthesis. An interim report. , 2003, Accounts of chemical research.

[46]  T. Kawabata,et al.  Total synthesis of spirotryprostatin B via asymmetric nitroolefination. , 2002, Organic letters.

[47]  I. Sattler,et al.  Maremycins C and D, New Diketopiperazines, and Maremycins E and F, Novel Polycyclic spiro‐Indole Metabolites Isolated from Streptomyces sp. , 2001 .

[48]  Â. Pinto,et al.  The chemistry of isatins: a review from 1975 to 1999 , 2001 .

[49]  Robert W. Armstrong,et al.  Multiple-Component Condensation Strategies for Combinatorial Library Synthesis , 1996 .