The virtual physiological human: tools and applications II

This issue of Phil. Trans. R. Soc. A is the second part of a double issue devoted to the virtual physiological human (VPH) initiative, which has been launched as part of the European Commission's Seventh Framework Programme for Research and Development. As highlighted in part I of the double issue

[1]  Peter J. Hunter,et al.  CellML metadata standards, associated tools and repositories , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[2]  Michael Kirley,et al.  A computational model for emergent dynamics in the kidney , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[3]  Topi Korhonen,et al.  Modelling sarcoplasmic reticulum calcium ATPase and its regulation in cardiac myocytes , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[4]  G. Prisk,et al.  Alveolar duct expansion greatly enhances aerosol deposition: a three-dimensional computational fluid dynamics study , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[5]  M Viceconti,et al.  The EuroPhysiome, STEP and a roadmap for the virtual physiological human , 2008, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[6]  J Douglas Armstrong,et al.  Towards a virtual fly brain , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[7]  Edmund J. Crampin,et al.  Multi-scale modelling and the IUPS physiome project , 2004, Journal of Molecular Histology.

[8]  Denis Noble,et al.  Markov models for ion channels: versatility versus identifiability and speed , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[9]  J. A. Sanz-Herrera,et al.  A mathematical approach to bone tissue engineering , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[10]  D. Noble,et al.  Mathematical models of the electrical action potential of Purkinje fibre cells , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[11]  G Harry van Lenthe,et al.  Multi-level patient-specific modelling of the proximal femur. A promising tool to quantify the effect of osteoporosis treatment , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[12]  David Gavaghan,et al.  Relationship between structural changes and hyperpolarized gas magnetic resonance imaging in chronic obstructive pulmonary disease using computational simulations with realistic alveolar geometry , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[13]  Peter J. Hunter,et al.  FieldML: concepts and implementation , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[14]  Christian Gerber,et al.  Numerical modelling of the shoulder for clinical applications , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[15]  Gordon Clapworthy,et al.  The virtual physiological human: building a framework for computational biomedicine I. Editorial. , 2008, Philosophical transactions. Series A, Mathematical, physical, and engineering sciences.

[16]  A. Tveito,et al.  Numerical solution of the bidomain equations , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[17]  J Vander Sloten,et al.  In silico biology of bone modelling and remodelling: regeneration , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[18]  Giorgio Fotia,et al.  Simulation of cardiac electrophysiology on next-generation high-performance computers , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[19]  K. Amunts,et al.  A systems perspective on the effective connectivity of overt speech production , 2009, NeuroImage.

[20]  P. Coveney,et al.  Crossing boundaries: computational science, e-Science and global e-Infrastructure , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[21]  James B. Bassingthwaighte,et al.  Strategies for the Physiome Project , 2000, Annals of Biomedical Engineering.

[22]  Ralph Müller,et al.  In silico biology of bone modelling and remodelling: adaptation , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[23]  Rajkumar Buyya,et al.  The Virtual Kidney: an eScience interface and Grid portal , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[24]  A. Garny,et al.  Chaste: incorporating a novel multi-scale spatial and temporal algorithm into a large-scale open source library , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[25]  David P Nickerson,et al.  A physiome standards-based model publication paradigm , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[26]  Denis Noble,et al.  Computational modelling of biological systems: tools and visions , 2000, Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[27]  Hannes Hettling,et al.  Robust modelling, measurement and analysis of human and animal metabolic systems , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[28]  Denis Noble,et al.  Cellular Open Resource (COR): current status and future directions , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[29]  George Em Karniadakis,et al.  Simulation of the human intracranial arterial tree. , 2009, Philosophical transactions. Series A, Mathematical, physical, and engineering sciences.

[30]  R.S. MacLeod,et al.  Subject-specific, multiscale simulation of electrophysiology: a software pipeline for image-based models and application examples , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[31]  David Gavaghan,et al.  Generation of histo-anatomically representative models of the individual heart: tools and application , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[32]  David Gavaghan,et al.  The virtual physiological human: tools and applications I , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[33]  Denis Noble,et al.  Integrative models of the heart: achievements and limitations , 2001, Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[34]  Josep A Planell,et al.  Computer-aided design and finite-element modelling of biomaterial scaffolds for bone tissue engineering , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[35]  Denis Noble,et al.  The IUPS human physiome project , 2002, Pflügers Archiv.

[36]  Stefano Severi,et al.  From in vivo plasma composition to in vitro cardiac electrophysiology and in silico virtual heart: the extracellular calcium enigma , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.