Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus.

left ventricular (LV) hypertrophy (cardiac hypertrophy) is generally considered a compensatory response of the heart to a variety of stimuli, most commonly altered workload. Although the most common cause of cardiac hypertrophy is essential hypertension in Western countries, virtually all forms of

[1]  J. Michel,et al.  Morphometric analysis of collagen network and plasma perfused capillary bed in the myocardium of rats during evolution of cardiac hypertrophy , 1986, Basic Research in Cardiology.

[2]  J. Ross,et al.  Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[3]  S. Vatner,et al.  The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. , 2002, The Journal of clinical investigation.

[4]  B. Gersh,et al.  And the answer is, it doesn't much matter. , 2002, Circulation.

[5]  P. Kang,et al.  Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice , 2002, Molecular and Cellular Biology.

[6]  K. Chien,et al.  Mixed signals in heart failure: cancer rules. , 2002, The Journal of clinical investigation.

[7]  Michael D. Schneider,et al.  MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[8]  W. Koch,et al.  Genetic Alterations That Inhibit In Vivo Pressure-Overload Hypertrophy Prevent Cardiac Dysfunction Despite Increased Wall Stress , 2002, Circulation.

[9]  D. Kass,et al.  The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[10]  K. Webster,et al.  Molecular mechanisms of apoptosis in the cardiac myocyte. , 2001, Current opinion in pharmacology.

[11]  G. Dorn,et al.  Cytoplasmic signaling pathways that regulate cardiac hypertrophy. , 2001, Annual review of physiology.

[12]  R. Kitsis,et al.  The MEK1–ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice , 2000, The EMBO journal.

[13]  R. Kerber,et al.  Cardiac hypertrophy is not a required compensatory response to short-term pressure overload. , 2000, Circulation.

[14]  P. Kang,et al.  The conserved phosphoinositide 3‐kinase pathway determines heart size in mice , 2000, The EMBO journal.

[15]  W. MacLellan,et al.  Genetic dissection of cardiac growth control pathways. , 2000, Annual review of physiology.

[16]  G. Stassi,et al.  Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat. , 1999, Circulation.

[17]  E. Olson,et al.  Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure. , 1999, Circulation research.

[18]  R. Lefkowitz,et al.  Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. , 1998, Science.

[19]  J Ross,et al.  Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family* , 1998, The Journal of Biological Chemistry.

[20]  G. Reboldi,et al.  Prognostic significance of serial changes in left ventricular mass in essential hypertension. , 1998, Circulation.

[21]  V. Smith,et al.  Effect of African-American race and hypertensive left ventricular hypertrophy on coronary vascular reactivity and endothelial function. , 1997, Hypertension.

[22]  J. Sadoshima,et al.  The cellular and molecular response of cardiac myocytes to mechanical stress. , 1997, Annual review of physiology.

[23]  S. Vatner,et al.  Coronary vascular morphology in pressure-overload left ventricular hypertrophy. , 1996, Journal of molecular and cellular cardiology.

[24]  D. Rizzoni,et al.  Association of change in left ventricular mass with prognosis during long-term antihypertensive treatment , 1995, Journal of hypertension.

[25]  S. Vatner,et al.  Hemodynamic mechanisms responsible for reduced subendocardial coronary reserve in dogs with severe left ventricular hypertrophy. , 1995, Circulation.

[26]  Daniel L. McGee,et al.  The relative effects of left ventricular hypertrophy, coronary artery disease, and ventricular dysfunction on survival among black adults. , 1995, JAMA.

[27]  R. Palmiter,et al.  Noradrenaline is essential for mouse fetal development , 1995, Nature.

[28]  G. Reboldi,et al.  Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension. , 1994, Hypertension.

[29]  D. Levy,et al.  Prognostic implications of baseline electrocardiographic features and their serial changes in subjects with left ventricular hypertrophy. , 1994, Circulation.

[30]  L. Rossi,et al.  Prognostic value of left ventricular mass in uncomplicated acute myocardial infarction and one-vessel coronary artery disease. , 1994, The American journal of cardiology.

[31]  J S Janicki,et al.  Impaired diastolic function and coronary reserve in genetic hypertension. Role of interstitial fibrosis and medial thickening of intramyocardial coronary arteries. , 1991, Circulation research.

[32]  J. Laragh,et al.  Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. , 1991, Annals of internal medicine.

[33]  D. Levy,et al.  Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. , 1990, The New England journal of medicine.

[34]  R. Tomanek.  Response of the coronary vasculature to myocardial hypertrophy. , 1990, Journal of the American College of Cardiology.

[35]  P. Parfrey,et al.  The clinical course of left ventricular hypertrophy in dialysis patients. , 1990, Nephron.

[36]  G. Condorelli,et al.  Blunted sympathetic response to cardiopulmonary receptor unloading in hypertensive patients with left ventricular hypertrophy. A possible compensatory role of atrial natriuretic factor. , 1989, Circulation.

[37]  S. Bishop,et al.  Vascular remodeling and improvement of coronary reserve after hydralazine treatment in spontaneously hypertensive rats. , 1989, Circulation research.

[38]  S. Shroff,et al.  Fibrillar Collagen and Myocardial Stiffness in the Intact Hypertrophied Rat Left Ventricle , 1989, Circulation research.

[39]  J S Janicki,et al.  Structural vs. contractile protein remodeling and myocardial stiffness in hypertrophied rat left ventricle. , 1988, Journal of molecular and cellular cardiology.

[40]  J. Laragh,et al.  Value of echocardiographic measurement of left ventricular mass in predicting cardiovascular morbid events in hypertensive men. , 1986, Annals of internal medicine.

[41]  R. Tomanek,et al.  Prevention of coronary vasodilator reserve decrement in spontaneously hypertensive rats. , 1985, Hypertension.

[42]  Róbert,et al.  Hemodynamic versus adrenergic control of cat right ventricular hypertrophy. , 1985, The Journal of clinical investigation.

[43]  C. Bloor,et al.  Myocardial characteristics of pressure overload hypertrophy. A structural and functional study. , 1984, Laboratory investigation; a journal of technical methods and pathology.

[44]  J. Greenfield,et al.  Relation of left ventricular mass to geometry of the proximal coronary arteries in the dog. , 1983, The American journal of cardiology.

[45]  Melvin L.Marcus,et al.  The Coronary Circulation in Health and Disease , 1983 .

[46]  S. Vatner,et al.  Reduction of Maximal Coronary Vasodilator Capacity in Conscious Dogs with Severe Right Ventricular Hypertrophy , 1981, Circulation research.

[47]  S. Houser,et al.  Myocardial blood flow and capillary density in chronic pressure overload of the feline left ventricle. , 1980, Cardiovascular research.

[48]  A. Ooshima,et al.  Cardiac hypertrophy in early hypertension. , 1979, The American journal of cardiology.

[49]  M. Pfeffer,et al.  Pumping Ability of the Hypertrophying Left Ventricle of the Spontaneously Hypertensive Rat , 1976, Circulation research.

[50]  O. Visioli,et al.  Myocardial blood flow in experimental cardiac hypertrophy in dogs. , 1973, Cardiovascular research.

[51]  J. D. Woods.  Relative ischaemia in the hypertrophied heart. , 1961, Lancet.

[52]  H. Levine,et al.  Coronary circulation in health and disease. , 1960, The Medical clinics of North America.

[53]  J. T. Wearn,et al.  Quantitative changes in the capillary-muscle relationship in human hearts during normal growth and hypertrophy , 1941 .