Focal radiation therapy for limited brain metastases is associated with high rates of local control and low subsequent whole brain radiation therapy

Assess clinical outcomes of focal radiotherapy (RT) in patients with limited brain metastasis (LBM) with whole brain RT (WBRT) avoidance.

[1]  J. Buckner,et al.  Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial. , 2017, The Lancet. Oncology.

[2]  Ruth E Langley,et al.  Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial , 2016, The Lancet.

[3]  Eudocia Q Lee,et al.  Updates in the management of brain metastases. , 2016, Neuro-oncology.

[4]  Volker W Stieber,et al.  Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial. , 2016, JAMA.

[5]  Satoshi Suzuki,et al.  Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study. , 2014, The Lancet. Oncology.

[6]  Y. Soon,et al.  Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases. , 2014, The Cochrane database of systematic reviews.

[7]  W. Curry,et al.  Clinical discussion and review of the management of brain metastases. , 2013, Journal of the National Comprehensive Cancer Network : JNCCN.

[8]  H. Choy,et al.  Primary analysis of a phase II randomized trial Radiation Therapy Oncology Group (RTOG) 0212: impact of different total doses and schedules of prophylactic cranial irradiation on chronic neurotoxicity and quality of life for patients with limited-disease small-cell lung cancer. , 2011, International journal of radiation oncology, biology, physics.

[9]  L. Collette,et al.  Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[10]  K. Hess,et al.  Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. , 2009, The Lancet. Oncology.

[11]  R. Soffietti,et al.  Brain metastases: current management and new developments , 2008, Current opinion in oncology.

[12]  Hiroki Shirato,et al.  Stereotactic Radiosurgery Plus Whole-Brain Radiation Therapy vs Stereotactic Radiosurgery Alone for Treatment of Brain Metastases: A Randomized Controlled Trial , 2007 .

[13]  T. Shakespeare,et al.  Interpreting the improved outcome of patients with central nervous system metastases managed in clinical trials compared with standard hospital practice. , 2005, Australasian radiology.

[14]  L. Deangelis,et al.  Treatment of Brain Metastases. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[15]  Maria Werner-Wasik,et al.  Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial , 2004, The Lancet.

[16]  Roy A Patchell,et al.  The management of brain metastases. , 2003, Cancer treatment reviews.

[17]  L D Lunsford,et al.  Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. , 1999, International journal of radiation oncology, biology, physics.

[18]  P. Levendag,et al.  Identification of prognostic factors in patients with brain metastases: a review of 1292 patients. , 1999, International journal of radiation oncology, biology, physics.

[19]  Robert N. Hughes,et al.  Cancer: Principles and Practice of Oncology , 2005 .

[20]  M. Kinay,et al.  Prognostic factors in lung cancer with brain metastasis , 1998 .