FREQUENCY OF COMMON BACTERIA AND THEIR SENSITIVITY TO ANTIBIOTICS IN PATIENTS OF NECROTIZING FASCIITIS

Objective: To determine the frequency of common bacteria and their sensitivity to antibiotics in patients of necrotizing fasciitis. Material and Methods: The study was conducted in the whole Department of Surgery including Orthopaedic Unit, Government Lady Reading Hospital, Peshawar. Study design was descriptive case series while duration of study was 6 months, from January 2012 to December 2012. Culture reports of 145 patients were performed and analyzed using SPSS 14.0 R . Results: In this study, 145 patients presenting with necrotizing fasciitis, female to male ratio was 1.46:1. Average age was 37.11 months + 14.17SD. Distribution of common bacteria shows that Beta Hemolytic streptococci and Klebsiella was found in majority of cases which were 73(50.3%) each, followed by proteus in 60(41.4%), E Coli and pseudomonas in 55(37.9%) each while 58(40%) patients have Streptococcus Viridans and Staphylococcus Aureus were observed in 51(35.2%) of patients. Seventy-five percent of klebsiella were sensitive to commonly available, cost effective drug like ampicillin. Conclusion: The key to overcoming the risk of this disease process is in rapid identification and prompt treatment of these lethal conditions associated with high morbity.

[1]  M. Musa,et al.  Necrotizing Fasciitis in Khartoum Teaching Hospital , 2012 .

[2]  D. Karakoç,et al.  What changed in necrotizing fasciitis in twenty-five years? , 2011 .

[3]  Yu-Cheng Hong,et al.  The microbiological profile and presence of bloodstream infection influence mortality rates in necrotizing fasciitis , 2011, Critical care.

[4]  S. Immerman,et al.  Techniques for early diagnosis and management of cervicofacial necrotising fasciitis , 2010, The Journal of Laryngology & Otology.

[5]  Cathy Thomas Hess,et al.  Skin & wound care , 2008 .

[6]  Hoang Q Pham,et al.  Incidence and clinical characteristics of methicillin-resistant Staphylococcus aureus necrotizing fasciitis in a large urban hospital. , 2007, American journal of surgery.

[7]  M. Granick,et al.  Necrotising fasciitis of upper and lower limb: a systematic review. , 2007, Injury.

[8]  Roberta B Carey,et al.  Invasive methicillin-resistant Staphylococcus aureus infections in the United States. , 2007, JAMA.

[9]  R. Salcido,et al.  Necrotizing Fasciitis: Reviewing the Causes and Treatment Strategies , 2007, Advances in skin & wound care.

[10]  L. Krenk,et al.  Necrotizing fasciitis in the head and neck region: an analysis of standard treatment effectiveness , 2007, European Archives of Oto-Rhino-Laryngology.

[11]  E. Dellinger,et al.  Necrotizing soft-tissue infection: diagnosis and management. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[12]  J. Byrnes Necrotizing Fasciitis: A Common Problem in Darwin , 2006, The international journal of lower extremity wounds.

[13]  H. Maltezou,et al.  Community-acquired methicillin-resistant Staphylococcus aureus infections. , 2006, International journal of antimicrobial agents.

[14]  B. Söderquist,et al.  Staphylococcus lugdunensis: clinical spectrum, antibiotic susceptibility, and phenotypic and genotypic patterns of 39 isolates. , 2006, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[15]  M. Peng,et al.  Rapidly progressive necrotizing fasciitis caused by Staphylococcus aureus. , 2005, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

[16]  H. Seifert,et al.  Staphylococcus lugdunensis Pacemaker-related Infection , 2005, Emerging infectious diseases.

[17]  Brad Spellberg,et al.  Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. , 2005, The New England journal of medicine.

[18]  A. Çağatay,et al.  Idiopathic Necrotizing Fasciitis: Risk Factors and Strategies for Management , 2005, The American surgeon.

[19]  Emily J McGee Necrotizing Fasciitis: Review of Pathophysiology, Diagnosis, and Treatment , 2005, Critical care nursing quarterly.

[20]  S. Tan,et al.  Recurrent necrotizing fasciitis caused by methicillin-resistant Staphylococcus aureus , 2004, European Journal of Clinical Microbiology and Infectious Diseases.

[21]  S. Schnall,et al.  Necrotizing fasciitis: clinical presentation, microbiology, and determinants of mortality. , 2004, The Journal of bone and joint surgery. American volume.

[22]  L. Ansaloni,et al.  Necrotizing fasciitis: a dramatic surgical emergency , 2004, European journal of emergency medicine : official journal of the European Society for Emergency Medicine.

[23]  F. Schildberg,et al.  Klebsiella pneumoniae Necrotizing F asciitis Associated w ith D iabetes a nd L iver C irrhosis , 2000 .

[24]  G. Sutton,et al.  Necrotizing Fasciitis of Vulvar Origin in Diabetic Patients , 1984, Obstetrics and gynecology.

[25]  C. M. Hudak,et al.  Critical care nursing , 1973 .