Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogen-activated protein kinase in mouse lung

[1]  S. Reddy,et al.  Mitogen Activated Protein Kinase Activated Protein Kinase 2 Regulates Actin Polymerization and Vascular Leak in Ventilator Associated Lung Injury , 2009, PloS one.

[2]  M. Crow,et al.  Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury. , 2008, Journal of applied physiology.

[3]  Xiongxiang Zhu,et al.  [Study on crosstalk between phosphatidylinositol 3 -kinase/Akt pathway and p38 mitogen-activated protein kinase pathway in cardiomyocyte with challenge of burn serum]. , 2008, Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.

[4]  M. Birnbaum,et al.  Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. , 2007, Cell metabolism.

[5]  T. Miyahara,et al.  Phosphoinositide 3-kinase, Src, and Akt modulate acute ventilation-induced vascular permeability increases in mouse lungs. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[6]  E. Ongini,et al.  Nitropravastatin stimulates reparative neovascularisation and improves recovery from limb Ischaemia in type‐1 diabetic mice , 2007, British journal of pharmacology.

[7]  B. Liagre,et al.  MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production. , 2007, International journal of molecular medicine.

[8]  Yong Jiang,et al.  Downregulation of human endothelial nitric oxide synthase promoter activity by p38 mitogen-activated protein kinase activation. , 2006, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[9]  Ssang-Goo Cho,et al.  Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis. , 2006, Biochimica et biophysica acta.

[10]  S. Reddy,et al.  Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways. , 2006, American journal of physiology. Lung cellular and molecular physiology.

[11]  J. Moss,et al.  Phosphatidylinositol 3-Kinase-dependent Suppression of the Human Inducible Nitric-oxide Synthase Promoter Is Mediated by FKHRL1* , 2006, Journal of Biological Chemistry.

[12]  J. Kang,et al.  p38 mitogen-activated protein kinase up-regulates LPS-induced NF-κB activation in the development of lung injury and RAW 264.7 macrophages , 2006 .

[13]  Meijing Wang,et al.  p38 mitogen-activated protein kinase mediates the sustained phase of hypoxic pulmonary vasoconstriction and plays a role in phase I vasodilation. , 2006, The Journal of surgical research.

[14]  M. Satouchi,et al.  Ventilator-induced lung injury is reduced in transgenic mice that overexpress endothelial nitric oxide synthase. , 2006, American journal of physiology. Lung cellular and molecular physiology.

[15]  J. Kang,et al.  p38 Mitogen-activated protein kinase up-regulates LPS-induced NF-kappaB activation in the development of lung injury and RAW 264.7 macrophages. , 2006, Toxicology.

[16]  N. Hay,et al.  Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo , 2005, Nature Medicine.

[17]  D. Predescu,et al.  Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[18]  R. Tuder,et al.  Inducible nitric oxide synthase contributes to ventilator-induced lung injury. , 2005, American journal of respiratory and critical care medicine.

[19]  W. Sessa,et al.  Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[20]  M. Birnbaum,et al.  Akt1/protein kinase Bα is critical for ischemic and VEGF-mediated angiogenesis , 2005 .

[21]  Avadhesh C. Sharma,et al.  Bigendothelin-1 (1-21) fragment during early sepsis modulates tau, p38-MAPK phosphorylation and nitric oxide synthase activation , 2005, Molecular and Cellular Biochemistry.

[22]  M. Birnbaum,et al.  Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. , 2005, The Journal of clinical investigation.

[23]  S. Vincent,et al.  Cytokines, nitric oxide, and cGMP modulate the permeability of an in vitro model of the human blood–brain barrier , 2004, Experimental Neurology.

[24]  T. Sairenji,et al.  Inhibition of Epstein-Barr Virus (EBV) Reactivation by Short Interfering RNAs Targeting p38 Mitogen-Activated Protein Kinase or c-myc in EBV-Positive Epithelial Cells , 2004, Journal of Virology.

[25]  H. Rabb,et al.  Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. , 2004, American journal of respiratory and critical care medicine.

[26]  D. Kwiatkowski,et al.  Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice. , 2003, American journal of respiratory cell and molecular biology.

[27]  Saptarsi M. Haldar,et al.  Wall Stiffness Suppresses Akt/eNOS and Cytoprotection in Pulse-Perfused Endothelium , 2003, Hypertension.

[28]  R. Groszmann,et al.  Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension. , 2002, American journal of physiology. Heart and circulatory physiology.

[29]  K. Pritchard,et al.  Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress. , 2001, Journal of applied physiology.

[30]  W. Sessa,et al.  Akt Down-regulation of p38 Signaling Provides a Novel Mechanism of Vascular Endothelial Growth Factor-mediated Cytoprotection in Endothelial Cells* , 2001, The Journal of Biological Chemistry.

[31]  K. Hirata,et al.  Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase. , 2000, Circulation.

[32]  A. Zeiher,et al.  Nitric oxide–an endothelial cell survival factor , 1999, Cell Death and Differentiation.

[33]  R. Busse,et al.  Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation , 1999, Nature.

[34]  D. Atsma,et al.  cGMP and nitric oxide modulate thrombin-induced endothelial permeability. Regulation via different pathways in human aortic and umbilical vein endothelial cells. , 1995, Circulation research.

[35]  P. Vincent,et al.  Simultaneous measurement of fluid and protein permeability in isolated rabbit lungs during edema. , 1992, Journal of applied physiology.

[36]  I. Ehrhart,et al.  Pressure-dependent increase in lung vascular permeability to water but not protein. , 1992, Journal of applied physiology.

[37]  D. Johnson,et al.  Transvascular flux and tissue accrual of Evans blue: effects of endotoxin and histamine. , 1988, The Journal of laboratory and clinical medicine.

[38]  W. Rössner,et al.  [Quantitative determination of the permeability of the so-called blood-brain barrier of Evans blue (T 1824)]. , 1966, Medicina et pharmacologia experimentalis. International journal of experimental medicine.