Anti-inflammatory effects of CBD in human microglial cell line infected with HIV-1

[1]  A. Vigano,et al.  Safety and Tolerability of Oral Cannabinoids in People Living with HIV on Long-Term ART: A Randomized, Open-Label, Interventional Pilot Clinical Trial (CTNPT 028) , 2022, Biomedicines.

[2]  M. Nair,et al.  Cannabidiol for neurodegenerative disorders: A comprehensive review , 2022, Frontiers in Pharmacology.

[3]  I. Chen,et al.  Cannabidiol modulates expression of type I IFN response genes and HIV infection in macrophages , 2022, Frontiers in Immunology.

[4]  Lei Yang,et al.  Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury , 2022, Frontiers in Immunology.

[5]  D. Sasayama,et al.  Altered levels of salivary cytokines in patients with major depressive disorder , 2022, Clinical Neurology and Neurosurgery.

[6]  L. Liotta,et al.  Cannabinoids Reduce Extracellular Vesicle Release from HIV-1 Infected Myeloid Cells and Inhibit Viral Transcription , 2022, Cells.

[7]  D. Meltzer,et al.  Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses. , 2022, Science advances.

[8]  W. Luo,et al.  MIF promotes neurodegeneration and cell death via its nuclease activity following traumatic brain injury , 2021, Cellular and Molecular Life Sciences.

[9]  S. Lewis Interspecies differences , 2021, Nature reviews. Neuroscience.

[10]  Jianmin Zhang,et al.  A Unique Type of Highly-Activated Microglia Evoking Brain Inflammation via Mif/Cd74 Signaling Axis in Aged Mice , 2021, Aging and disease.

[11]  G. Sarnelli,et al.  Cannabidiol inhibits SARS‐Cov‐2 spike (S) protein‐induced cytotoxicity and inflammation through a PPARγ‐dependent TLR4/NLRP3/Caspase‐1 signaling suppression in Caco‐2 cell line , 2021, Phytotherapy research : PTR.

[12]  C. Mactutus,et al.  Neurodevelopmental Processes in the Prefrontal Cortex Derailed by Chronic HIV-1 Viral Protein Exposure , 2021, bioRxiv.

[13]  R. Bateman,et al.  Plasma MCP-1 and changes on cognitive function in community-dwelling older adults , 2021, Alzheimer's research & therapy.

[14]  E. Masliah,et al.  Central nervous system (CNS) transcriptomic correlates of human immunodeficiency virus (HIV) brain RNA load in HIV-infected individuals , 2021, Scientific Reports.

[15]  J. Rohrer,et al.  Differential chemokine alteration in the variants of primary progressive aphasia—a role for neuroinflammation , 2021, Journal of Neuroinflammation.

[16]  R. Crystal,et al.  HIV induces airway basal progenitor cells to adopt an inflammatory phenotype , 2021, Scientific Reports.

[17]  Tinggang Wang,et al.  TGF-β1-Mediated Activation of SERPINE1 is Involved in Hemin-Induced Apoptotic and Inflammatory Injury in HT22 Cells , 2021, Neuropsychiatric disease and treatment.

[18]  O. Kovalchuk,et al.  Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective , 2021, Frontiers in Immunology.

[19]  Puneet Kumar,et al.  Neuroprotection through G-CSF: recent advances and future viewpoints , 2021, Pharmacological Reports.

[20]  Z. Xi,et al.  Possible Receptor Mechanisms Underlying Cannabidiol Effects on Addictive-like Behaviors in Experimental Animals , 2020, International journal of molecular sciences.

[21]  B. Staitieh,et al.  GM-CSF Reverses HIV Protein-Induced Mitochondrial Derangements in Alveolar Macrophages. , 2020, AIDS research and human retroviruses.

[22]  O. Kann,et al.  GM-CSF induces noninflammatory proliferation of microglia and disturbs electrical neuronal network rhythms in situ , 2020, Journal of Neuroinflammation.

[23]  T. Swartz,et al.  NLRP3 Inflammasome Signaling as a Link Between HIV-1 Infection and Atherosclerotic Cardiovascular Disease , 2020, Frontiers in Cardiovascular Medicine.

[24]  N. Seeram,et al.  Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes. , 2020, Journal of natural products.

[25]  P. Huerta,et al.  Key role of MIF-related neuroinflammation in neurodegeneration and cognitive impairment in Alzheimer’s disease , 2020, Molecular medicine.

[26]  Barbara L F Kaplan,et al.  Immune Responses Regulated by Cannabidiol , 2020, Cannabis and cannabinoid research.

[27]  I. Rahman,et al.  Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts. , 2019, Toxicology and applied pharmacology.

[28]  Zhenfeng Zhang,et al.  Cannabidiol protects livers against nonalcoholic steatohepatitis induced by high‐fat high cholesterol diet via regulating NF‐κB and NLRP3 inflammasome pathway , 2019, Journal of cellular physiology.

[29]  N. Kaminski,et al.  Δ9-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7–Stimulated Human Coculture , 2019, The Journal of Pharmacology and Experimental Therapeutics.

[30]  J. Routy,et al.  Cannabis Consumption in People Living with HIV: Reasons for Use, Secondary Effects, and Opportunities for Health Education. , 2019, Cannabis and cannabinoid research.

[31]  anonymous,et al.  Comprehensive review , 2019 .

[32]  M. Nagarkatti,et al.  Combination of Cannabinoids, Δ9- Tetrahydrocannabinol and Cannabidiol, Ameliorates Experimental Multiple Sclerosis by Suppressing Neuroinflammation Through Regulation of miRNA-Mediated Signaling Pathways , 2019, Front. Immunol..

[33]  J. Kong,et al.  Therapeutic impact of orally administered cannabinoid oil extracts in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis. , 2019, Biochemical and biophysical research communications.

[34]  H. Weiner,et al.  Microglial signatures and their role in health and disease , 2018, Nature Reviews Neuroscience.

[35]  N. Kaminski,et al.  HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-&ggr;-inducible protein 10 levels compared with nonusing HIV patients , 2017, AIDS.

[36]  M. Nagarkatti,et al.  Combination of cannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), mitigates experimental autoimmune encephalomyelitis (EAE) by altering the gut microbiome , 2017, Brain, Behavior, and Immunity.

[37]  M. Colonna,et al.  Microglia Function in the Central Nervous System During Health and Neurodegeneration. , 2017, Annual review of immunology.

[38]  Qingwu Yang,et al.  Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage , 2016, Molecular Neurobiology.

[39]  J. Karn,et al.  Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells , 2017, Retrovirology.

[40]  N. Toyang,et al.  Potential of Cannabidiol for the Treatment of Viral Hepatitis , 2017, Pharmacognosy research.

[41]  E. Mazzon,et al.  Cannabidiol Modulates the Expression of Alzheimer’s Disease-Related Genes in Mesenchymal Stem Cells , 2016, International journal of molecular sciences.

[42]  G. Appendino,et al.  Phytocannabinoids: a unified critical inventory. , 2016, Natural product reports.

[43]  J. Karn,et al.  Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system , 2016, Journal of NeuroVirology.

[44]  V. Sagar,et al.  Effect of Cocaine on HIV Infection and Inflammasome Gene Expression Profile in HIV Infected Macrophages , 2016, Scientific Reports.

[45]  Y. Shoenfeld,et al.  Cannabinoids and autoimmune diseases: A systematic review. , 2016, Autoimmunity reviews.

[46]  Adriana Yndart,et al.  Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC) , 2015, Front. Microbiol..

[47]  S. Saxena,et al.  Investigation of Neuropathogenesis in HIV-1 Clade B and C Infection Associated with IL-33 and ST2 Regulation. , 2015, ACS chemical neuroscience.

[48]  Haitao Guo,et al.  Inflammasomes: mechanism of action, role in disease, and therapeutics , 2015, Nature Medicine.

[49]  T. Miyata,et al.  Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis , 2015, PloS one.

[50]  W. Banks,et al.  Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications , 2015, Brain, Behavior, and Immunity.

[51]  Toshio Tanaka,et al.  IL-6 in inflammation, immunity, and disease. , 2014, Cold Spring Harbor perspectives in biology.

[52]  J. Berman,et al.  Mechanisms of HIV Entry into the CNS: Increased Sensitivity of HIV Infected CD14+CD16+ Monocytes to CCL2 and Key Roles of CCR2, JAM-A, and ALCAM in Diapedesis , 2013, PloS one.

[53]  Xu Wang,et al.  Attenuation of HIV‐1 replication in macrophages by cannabinoid receptor 2 agonists , 2013, Journal of leukocyte biology.

[54]  E. Mohammadi,et al.  Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence , 2017, International journal for quality in health care : journal of the International Society for Quality in Health Care.

[55]  P. Molina,et al.  Cannabinoid administration attenuates the progression of simian immunodeficiency virus. , 2011, AIDS research and human retroviruses.

[56]  M. Nagarkatti,et al.  Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. , 2010, Immunobiology.

[57]  M. Glass,et al.  Meta‐analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences , 2007, British journal of pharmacology.

[58]  N. Bresolin,et al.  Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer's disease , 2006, Neurobiology of Aging.

[59]  T. Klein,et al.  Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells , 2006, Journal of Neuroimmune Pharmacology.

[60]  E. Ponomarev,et al.  Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli , 2005, Journal of neurochemistry.

[61]  M. Lederman,et al.  Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma human immunodeficiency virus (HIV) type 1 RNA levels and CD4+ lymphocyte counts in patients with uncontrolled HIV infection. , 2003, The Journal of infectious diseases.

[62]  Raphael Mechoulam,et al.  Cannabidiol: An Overview of Some Pharmacological Aspects , 2002, Journal of clinical pharmacology.

[63]  D. Ponde,et al.  Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide , 2001, British journal of pharmacology.

[64]  V. Appay,et al.  RANTES: a versatile and controversial chemokine. , 2001, Trends in immunology.

[65]  J. Angel,et al.  Phase III study of granulocyte-macrophage colony-stimulating factor in advanced HIV disease: effect on infections, CD4 cell counts and HIV suppression , 2000 .

[66]  S. Arya,et al.  Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells , 1995, Science.

[67]  V. Perry,et al.  Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain , 1990, Neuroscience.

[68]  J. Groopman,et al.  Effect of recombinant human granulocyte-macrophage colony-stimulating factor on myelopoiesis in the acquired immunodeficiency syndrome. , 1987, The New England journal of medicine.

[69]  N. Kaminski,et al.  Δ9-Tetrahydrocannabinol suppresses monocyte-mediated astrocyte production of MCP-1 and IL-6 in a TLR7-stimulated human co-culture. , 2019, The Journal of pharmacology and experimental therapeutics.

[70]  R. Thangavel,et al.  Neuroinflammation Induces Neurodegeneration. , 2016, Journal of neurology, neurosurgery and spine.

[71]  Soon-Cheang Quah,et al.  A Current Perspective , 2007 .

[72]  J. Angel,et al.  Phase III study of granulocyte-macrophage colony-stimulating factor in advanced HIV disease: effect on infections, CD4 cell counts and HIV suppression. Leukine/HIV Study Group. , 2000, AIDS.

[73]  D. Skiest,et al.  Granulocyte colony-stimulating factor use is associated with decreased bacteremia and increased survival in neutropenic HIV-infected patients. , 1998, The American journal of medicine.

[74]  S. Arya,et al.  Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. , 1995, Science.

[75]  C. Newton,et al.  IL-1 beta and TNF alpha modulate delta 9-tetrahydrocannabinol-induced catalepsy in mice. , 1995, Pharmacology, biochemistry, and behavior.