Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes.

[1]  A. Tsujikawa,et al.  Argatroban Attenuates Leukocyte– and Platelet–Endothelial Cell Interactions After Transient Retinal Ischemia , 2003, Stroke.

[2]  Y. Ogura,et al.  Platelets accumulate in the diabetic retinal vasculature following endothelial death and suppress blood-retinal barrier breakdown. , 2003, The American journal of pathology.

[3]  K. Yamashiro,et al.  VEGF164 is proinflammatory in the diabetic retina. , 2003, Investigative ophthalmology & visual science.

[4]  Bernd Kirchhof,et al.  The FASEB Journal express article 10.1096/fj.02-0157fje. Published online November 15, 2002. Suppression of Fas-FasL-induced endothelial cell apoptosis , 2022 .

[5]  W. Seeger,et al.  Simvastatin Inhibits Inflammatory Properties of Staphylococcus aureus &agr;-Toxin , 2002, Circulation.

[6]  B. Kasiske,et al.  Protective Effect of HMG-CoA Reductase Inhibitor on Experimental Renal Ischemia-Reperfusion Injury , 2002, American Journal of Nephrology.

[7]  F. Luft,et al.  Postischemic acute renal failure is reduced by short-term statin treatment in a rat model. , 2002, Journal of the American Society of Nephrology : JASN.

[8]  J. Cristol,et al.  Simvastatin Prevents Angiotensin II–Induced Cardiac Alteration and Oxidative Stress , 2002, Hypertension.

[9]  S. Bursell,et al.  Suppression of diabetic retinopathy with angiopoietin-1. , 2002, The American journal of pathology.

[10]  R. Pandey,et al.  Simvastatin retards progression of retinopathy in diabetic patients with hypercholesterolemia. , 2002, Diabetes research and clinical practice.

[11]  Bernd Kirchhof,et al.  Nonsteroidal anti‐inflammatory drugs prevent early diabetic retinopathy via TNF‐α suppression , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[12]  C. Heeschen,et al.  Statins Have Biphasic Effects on Angiogenesis , 2002, Circulation.

[13]  Bernd Kirchhof,et al.  Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. , 2002, The American journal of pathology.

[14]  D. Teupser,et al.  HMG-CoA reductase inhibitors reduce adhesion of human monocytes to endothelial cells. , 2001, Biochemical and biophysical research communications.

[15]  H. Kiyama,et al.  Constitutive nitric oxide synthase is associated with retinal vascular permeability in early diabetic rats , 2001, Diabetologia.

[16]  R. Gerszten,et al.  HMG-CoA Reductase Inhibitor Modulates Monocyte-Endothelial Cell Interaction Under Physiological Flow Conditions In Vitro: Involvement of Rho GTPase-Dependent Mechanism , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[17]  Steven P Jones,et al.  HMG‐CoA reductase inhibition protects the diabetic myocardium from ischemia‐reperfusion injury , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[18]  J. Soria,et al.  Inhibition of endothelial cell migration by cerivastatin, an HMG‐CoA reductase inhibitor: contribution to its anti‐angiogenic effect , 2001, FEBS letters.

[19]  Hyung Jin Kim,et al.  Vascular Endothelial Growth Factor Expression of Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule 1 (VCAM-1), and E-selectin through Nuclear Factor-κB Activation in Endothelial Cells* , 2001, The Journal of Biological Chemistry.

[20]  D. Ganten,et al.  Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effects. , 2000, Kidney international.

[21]  H. Ovadia,et al.  Renal nitric oxide production during the early phase of experimental diabetes mellitus. , 2000, Kidney international.

[22]  Y. Ogura,et al.  PKC-beta inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats. , 2000, Investigative ophthalmology & visual science.

[23]  Z. Radisavljevic,et al.  Vascular Endothelial Growth Factor Up-regulates ICAM-1 Expression via the Phosphatidylinositol 3 OH-kinase/AKT/Nitric Oxide Pathway and Modulates Migration of Brain Microvascular Endothelial Cells* , 2000, The Journal of Biological Chemistry.

[24]  Y. Okada,et al.  Coexpression of VEGF receptors VEGF-R2 and neuropilin-1 in proliferative diabetic retinopathy. , 2000, Investigative ophthalmology & visual science.

[25]  G. Davı̀,et al.  Fluvastatin reduces soluble P-selectin and ICAM-1 levels in hypercholesterolemic patients: role of nitric oxide. , 2000, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

[26]  K Miyamoto,et al.  Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1). , 2000, The American journal of pathology.

[27]  A. Marette,et al.  Mechanism of impaired nitric oxide synthase activity in skeletal muscle of streptozotocin-induced diabetic rats , 2000, Diabetologia.

[28]  K Miyamoto,et al.  Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. , 2000, Investigative ophthalmology & visual science.

[29]  W. Reenstra,et al.  Hyperbaric oxygen downregulates ICAM-1 expression induced by hypoxia and hypoglycemia: the role of NOS. , 2000, American journal of physiology. Cell physiology.

[30]  A. M. Lefer,et al.  Simvastatin inhibits leukocyte-endothelial cell interactions and protects against inflammatory processes in normocholesterolemic rats. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[31]  J. Panés,et al.  Differential effects of a nitric oxide donor on reperfusion-induced microvascular dysfunction in diabetic and non-diabetic rats , 1999, Diabetologia.

[32]  L. Aiello,et al.  Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[33]  A. M. Lefer,et al.  Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts. , 1999, Circulation.

[34]  K Miyamoto,et al.  VEGF increases retinal vascular ICAM-1 expression in vivo. , 1999, Investigative ophthalmology & visual science.

[35]  E. Oldfield,et al.  Vascular endothelial growth factor (VEGF) modulates vascular permeability and inflammation in rat brain. , 1999, Journal of neuropathology and experimental neurology.

[36]  A. Dabrowska,et al.  Lovastatin and tumor necrosis factor‐α exhibit potentiated antitumor effects against Ha‐ras‐transformed murine tumor Via inhibition of tumor‐induced angiogenesis , 1999, International journal of cancer.

[37]  K Miyamoto,et al.  In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats. , 1998, Investigative ophthalmology & visual science.

[38]  T. Rabelink,et al.  Nitric oxide availability in diabetes mellitus. , 1998, Diabetes/metabolism reviews.

[39]  J. Liao,et al.  Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants , 1998, Journal of leukocyte biology.

[40]  J. Cunha-Vaz,et al.  Nitric oxide synthase activity and L-arginine metabolism in the retinas from streptozotocin-induced diabetic rats. , 1998, General pharmacology.

[41]  U. Laufs,et al.  Inhibition of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Blocks Hypoxia-mediated Down-regulation of Endothelial Nitric Oxide Synthase* , 1997, The Journal of Biological Chemistry.

[42]  Y. Ogura,et al.  Role of leukocytes in diabetic microcirculatory disturbances. , 1997, Microvascular research.

[43]  H. Yamashita,et al.  Vascular endothelial growth factor in diabetic retinopathy , 1997, The Lancet.

[44]  D. Lefer,et al.  Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. , 1995, The American journal of pathology.

[45]  L. Aiello,et al.  Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. , 1994, The New England journal of medicine.

[46]  A Mathis,et al.  Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. , 1994, Archives of ophthalmology.

[47]  Joan W. Miller,et al.  Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. , 1994, American journal of ophthalmology.

[48]  F. Luscinskas,et al.  Integrins as dynamic regulators of vascular function , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[49]  P. Kubes,et al.  Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils. , 1994, Circulation research.

[50]  L. Yannuzzi,et al.  The effects of lipid lowering on diabetic retinopathy. , 1991, American journal of ophthalmology.

[51]  D. Wallwiener,et al.  Further evidence for direct vascular actions of statins: effect on endothelial nitric oxide synthase and adhesion molecules. , 2001, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[52]  B Kirchhof,et al.  Leukocyte-mediated endothelial cell injury and death in the diabetic retina. , 2001, The American journal of pathology.

[53]  K. Miyarnoto Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition , 1999 .

[54]  R. Caldwell,et al.  Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions. , 1999, Journal of the American College of Cardiology.

[55]  D. Eliott,et al.  Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy. , 1997, Investigative ophthalmology & visual science.

[56]  Y. Ogura,et al.  Quantitative evaluation of leukocyte dynamics in retinal microcirculation. , 1995, Investigative ophthalmology & visual science.

[57]  W. Sluiter,et al.  Leukocyte adhesion molecules on the vascular endothelium: their role in the pathogenesis of cardiovascular disease and the mechanisms underlying their expression. , 1993, Journal of cardiovascular pharmacology.