Ultraviolet radiation-mediated damage to cellular DNA.

[1]  R. Tyrrell,et al.  INDUCTION OF PYRIMIDINE DIMERS IN BACTERIAL DNA BY 365 nm RADIATION * , 1973, Photochemistry and photobiology.

[2]  D. Mitchell,et al.  The development of a radioimmunoassay for the detection of photoproducts in mammalian cell DNA. , 1981, Biochimica et biophysica acta.

[3]  J. Cadet,et al.  Rapid quantitation of ultraviolet-induced thymine-containing dimers in human cell DNA by reversed-phase high-performance liquid chromatography. , 1983, Journal of chromatography.

[4]  P. Cerutti,et al.  Cyclobutane-type pyrimidine photodimer formation and excision in human skin fibroblasts after irradiation with 313-nm ultraviolet light. , 1983, Biochemistry.

[5]  J. Cadet,et al.  Radiation-induced decomposition of the purine bases within DNA and related model compounds. , 1985, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[6]  R. Schaaper,et al.  The C-C (6-4) UV photoproduct is mutagenic in Escherichia coli. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[7]  R. Baan,et al.  DETECTION OF CYCLOBUTANE THYMINE DIMERS IN DNA OF HUMAN CELLS WITH MONOCLONAL ANTIBODIES RAISED AGAINST A THYMINE DIMER‐ CONTAINING TETRANUCLEOTIDE , 1988, Photochemistry and photobiology.

[8]  J. Sutherland,et al.  Wavelength dependence of pyrimidine dimer formation in DNA of human skin irradiated in situ with ultraviolet light. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[9]  M. Paterson,et al.  Enzymatic analysis of isomeric trithymidylates containing ultraviolet light-induced cyclobutane pyrimidine dimers. I. Nuclease P1-mediated hydrolysis of the intradimer phosphodiester linkage. , 1989, The Journal of biological chemistry.

[10]  H. Morrison.  Photochemistry and the nucleic acids , 1990 .

[12]  O. Nikaido,et al.  Establishment of a monoclonal antibody recognizing cyclobutane-type thymine dimers in DNA: a comparative study with 64M-1 antibody specific for (6-4)photoproducts. , 1991, Mutation research.

[13]  O. Nikaido,et al.  SIMULTANEOUS ESTABLISHMENT OF MONOCLONAL ANTIBODIES SPECIFIC FOR EITHER CYCLOBUTANE PYRIMIDINE DIMER OR (6‐4)PHOTOPRODUCT FROM THE SAME MOUSE IMMUNIZED WITH ULTRAVIOLET‐IRRADIATED DNA , 1991, Photochemistry and photobiology.

[14]  J. Cadet,et al.  The Dewar valence isomer of the (6-4) photoadduct of thymidylyl-(3'-5')-thymidine monophosphate: formation, alkaline lability and conformational properties. , 1992, Journal of photochemistry and photobiology. B, Biology.

[15]  O. Nikaido,et al.  ESTABLISHMENT and CHARACTERIZATION OF A MONOCLONAL ANTIBODY RECOGNIZING THE DEWAR ISOMERS OF(6–4)PHOTOPRODUCTS , 1993, Photochemistry and photobiology.

[16]  K. G. Jensen,et al.  SHORT COMMUNICATION: Effect of ascorbate and 5-aminosalicylic acid on light-induced 8-hydroxydeoxyguanosine formation in V79 Chinese hamster cells , 1993 .

[17]  E. Sage.  DISTRIBUTION AND REPAIR OF PHOTOLESIONS IN DNA: GENETIC CONSEQUENCES AND THE ROLE OF SEQUENCE CONTEXT , 1993, Photochemistry and photobiology.

[18]  L. Roza,et al.  Flow cytometric immunofluorescence assay for quantification of cyclobutyldithymine dimers in separate phases of the cell cycle. , 1993, Carcinogenesis.

[19]  S. Tornaletti,et al.  The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer. , 1993, Oncogene.

[20]  R. Tyrrell,et al.  Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. , 1993, The Journal of biological chemistry.

[21]  R. Setlow,et al.  Wavelengths effective in induction of malignant melanoma. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[22]  A. Parker,et al.  Singlet oxygen sensitisation by excited state DNA , 1994 .

[23]  JohnB . Taylor,et al.  UNRAVELING THE MOLECULAR PATHWAY FROM SUNLIGHT TO SKIN CANCER , 1994 .

[24]  J. Cadet,et al.  Formation of cyclobutane dimers and (6-4) photoproducts upon far-UV photolysis of 5-methylcytosine-containing dinucleotide monophosphates. , 1994, Biochemistry.

[25]  E. Drobetsky,et al.  A role for ultraviolet A in solar mutagenesis. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[26]  K. Hemminki,et al.  UV-induced photoproducts in human skin explants analysed by TLC and HPLC-radioactivity detection. , 1995, Carcinogenesis.

[27]  J. Cadet,et al.  Chemical Aspects of the Benzophenone-Photosensitized Formation of Two Lysine-2'-deoxyguanosine Cross-Links , 1995 .

[28]  G. Cameron,et al.  Antioxidant nutrients protect against UVB-induced oxidative damage to DNA of mouse keratinocytes in culture. , 1996, The Journal of investigative dermatology.

[29]  T. Mohammad,et al.  Evidence for the Photosensitized Formation of Singlet Oxygen by UVB Irradiation of 2‘-Deoxyguanosine 5‘-Monophosphate1 , 1996 .

[30]  E. Sage,et al.  Mutagenic specificity of solar UV light in nucleotide excision repair-deficient rodent cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[31]  J. E. Rosen,et al.  8‐Oxodeoxyguanosine Formation in the DNA of Cultured Cells After Exposure to H2O2 Alone or with UVB or UVA Irradiation , 1996, Photochemistry and photobiology.

[32]  G. Pfeifer.  Technologies for Detection of DNA Damage and Mutations , 1996, Springer US.

[33]  D. Mitchell.  Radioimmunoassay of DNA Damaged by Ultraviolet Light , 1996 .

[34]  G. Pfeifer,et al.  Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases. , 1997, Cancer research.

[35]  A. Laat,et al.  Carcinogenesis induced by UVA (365-nm) radiation: the dose-time dependence of tumor formation in hairless mice , 1997 .

[36]  J. Cadet,et al.  Effects of UV and visible radiation on DNA-final base damage. , 1997, Biological chemistry.

[37]  B. Epe,et al.  Wavelength dependence of oxidative DNA damage induced by UV and visible light. , 1997, Carcinogenesis.

[38]  J. Cadet,et al.  Far‐UV‐lnduced Dimeric Photoproducts in Short Oligonucleotides: Sequence Effects , 1997, Photochemistry and photobiology.

[39]  de Gruijl Fr,et al.  Low Incidence of p53 Mutations in UVA (365-nm)-induced Skin Tumors in Hairless Mice , 1997 .

[40]  J. Cadet,et al.  Oxidative damage to DNA: formation, measurement, and biological significance. , 1997, Reviews of physiology, biochemistry and pharmacology.

[41]  R. Wei,et al.  In vitro Photooxidation of Nucleic Acids by Ultraviolet A Radiation , 1997, Photochemistry and photobiology.

[42]  M. Lebwohl,et al.  Induction of 8‐Oxo‐7,8‐Dihydro‐2'‐Deoxyguanosine by Ultraviolet Radiation in Calf Thymus DNA and HeLa Cells , 1997, Photochemistry and photobiology.

[43]  R. Tyrrell,et al.  Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation. , 1997, Carcinogenesis.

[44]  C. Smith,et al.  Ultraviolet Irradiation Produces Novel Endonuclease Ill‐Sensitive Cytosine Photoproducts at Dipyrimidine Sites , 1997, Photochemistry and photobiology.

[45]  M. Lebwohl,et al.  Tamoxifen reduces endogenous and UV light-induced oxidative damage to DNA, lipid and protein in vitro and in vivo. , 1998, Carcinogenesis.

[46]  C. Potten,et al.  Human melanocytes and keratinocytes exposed to UVB or UVA in vivo show comparable levels of thymine dimers. , 1998, The Journal of investigative dermatology.

[47]  J. Cadet,et al.  Use of the single-cell gel electrophoresis assay for the immunofluorescent detection of specific DNA damage. , 1998, Analytical biochemistry.

[48]  B. Epe,et al.  Oxidative DNA damage induced by visible light in mammalian cells: extent, inhibition by antioxidants and genotoxic effects. , 1998, Mutation research.

[49]  B. A. Kunz,et al.  DNA repair in higher plants. , 1998, Mutation research.

[50]  C. Scaletta,et al.  Sunlight and carcinogenesis: Expression of p53 and pyrimidine dimers in human skin following UVA I, UVA I + II and solar simulating radiations , 1998, International journal of cancer.

[51]  R. Tyrrell,et al.  Ultraviolet A radiation induces immediate release of iron in human primary skin fibroblasts: the role of ferritin. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[52]  R. Drouin,et al.  Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repair. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[53]  J. Cadet,et al.  L‐arginine increases UVA cytotoxicity in irradiated human keratinocyte cell line: potential role of nitric oxide , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[54]  D. Mitchell,et al.  Effects of chronic low-dose ultraviolet B radiation on DNA damage and repair in mouse skin. , 1999, Cancer research.

[55]  K. Hemminki,et al.  In situ repair of cyclobutane pyrimidine dimers and 6-4 photoproducts in human skin exposed to solar simulating radiation. , 1999, The Journal of investigative dermatology.

[56]  Y. Komatsu,et al.  Conformational multiplicity of the antibody combining site of a monoclonal antibody specific for a (6-4) photoproduct. , 1999, Journal of molecular biology.

[57]  R. Drouin,et al.  The multilayered organization of engineered human skin does not influence the formation of sunlight-induced cyclobutane pyrimidine dimers in cellular DNA. , 1999, Cancer research.

[58]  J. Cadet,et al.  Oxidation of Guanine in Cellular DNA by Solar UV Radiation: Biological Role † , 1999, Photochemistry and photobiology.

[59]  C. Scaletta,et al.  In vivo induction of pyrimidine dimers in human skin by UVA radiation: initiation of cell damage and/or intercellular communication? , 1999, International journal of molecular medicine.

[60]  K. Hemminki,et al.  Effect of age on the formation and repair of UV photoproducts in human skin in situ. , 2000, Mutation research.

[61]  A. A. Vink,et al.  Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[62]  E. Sage,et al.  Distribution and repair of bipyrimidine photoproducts in solar UV-irradiated mammalian cells. Possible role of Dewar photoproducts in solar mutagenesis. , 2000, The Journal of biological chemistry.

[63]  J. Ravanat,et al.  Synthesis of a Naphthalene Endoperoxide as a Source of 18O-labeled Singlet Oxygen for Mechanistic Studies , 2000 .

[64]  J. Cadet,et al.  Singlet Oxygen Induces Oxidation of Cellular DNA* , 2000, The Journal of Biological Chemistry.

[65]  J. Cadet,et al.  High-performance liquid chromatography--tandem mass spectrometry measurement of radiation-induced base damage to isolated and cellular DNA. , 2000, Chemical research in toxicology.

[66]  T. Todo,et al.  Respective roles of cyclobutane pyrimidine dimers, (6-4)photoproducts, and minor photoproducts in ultraviolet mutagenesis of repair-deficient xeroderma pigmentosum A cells. , 2000, Cancer research.

[67]  G. Pfeifer,et al.  Cyclobutane pyrimidine dimers form preferentially at the major p53 mutational hotspot in UVB-induced mouse skin tumors. , 2000, Carcinogenesis.

[68]  B. Epe,et al.  DNA damage induced by ultraviolet and visible light and its wavelength dependence. , 2000, Methods in enzymology.

[69]  G. Pfeifer,et al.  Cell cycle-independent removal of UV-induced pyrimidine dimers from the promoter and the transcription initiation domain of the human CDC2 gene. , 2000, Nucleic acids research.

[70]  J. Cadet,et al.  DNA damage induced in cells by gamma and UVA radiation as measured by HPLC/GC-MS and HPLC-EC and Comet assay. , 2000, Chemical research in toxicology.

[71]  Y. Komatsu,et al.  Crystal structure of the 64M-2 antibody Fab fragment in complex with a DNA dT(6-4)T photoproduct formed by ultraviolet radiation. , 2000, Journal of molecular biology.

[72]  de Gruijl Fr.  Photocarcinogenesis: UVA vs UVB. , 2000, Methods in enzymology.

[73]  J. Cadet,et al.  Electrospray-mass spectrometry characterization and measurement of far-UV-induced thymine photoproducts. , 2000, Journal of photochemistry and photobiology. B, Biology.

[74]  A. Yasui,et al.  The DNA damage spectrum produced by simulated sunlight. , 2000, Journal of molecular biology.

[75]  J. Cadet,et al.  Formation of the Main UV-induced Thymine Dimeric Lesions within Isolated and Cellular DNA as Measured by High Performance Liquid Chromatography-Tandem Mass Spectrometry* , 2000, The Journal of Biological Chemistry.

[76]  M. Hollstein,et al.  UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin. , 2001, Cancer research.

[77]  A. Sarasin,et al.  Clues to epidermal cancer proneness revealed by reconstruction of DNA repair-deficient xeroderma pigmentosum skin in vitro , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[78]  J. Cadet,et al.  Effects of UV and visible radiations on cellular DNA. , 2001, Current problems in dermatology.

[79]  P. Duez,et al.  Photodynamic DNA damage mediated by δ-aminolevulinic acid-induced porphyrins , 2001 .

[80]  G. Pfeifer,et al.  Similarities in sunlight-induced mutational spectra of CpG-methylated transgenes and the p53 gene in skin cancer point to an important role of 5-methylcytosine residues in solar UV mutagenesis. , 2001, Journal of molecular biology.

[81]  J. Cadet,et al.  Repair of the main UV-induced thymine dimeric lesions within Arabidopsis thaliana DNA: evidence for the major involvement of photoreactivation pathways. , 2001, Journal of photochemistry and photobiology. B, Biology.

[82]  S. Nakajima,et al.  Cyclobutane Pyrimidine Dimers Are Responsible for the Vast Majority of Mutations Induced by UVB Irradiation in Mammalian Cells* , 2001, The Journal of Biological Chemistry.

[83]  J. Cadet,et al.  Direct and indirect effects of UV radiation on DNA and its components. , 2001, Journal of photochemistry and photobiology. B, Biology.

[84]  J. Cadet,et al.  Individual determination of the yield of the main UV-induced dimeric pyrimidine photoproducts in DNA suggests a high mutagenicity of CC photolesions. , 2001, Biochemistry.

[85]  L. Marnett.  Oxy radicals, lipid peroxidation and DNA damage. , 2002, Toxicology.

[86]  R. Drouin,et al.  A physical sunscreen protects engineered human skin against artificial solar ultraviolet radiation-induced tissue and DNA damage , 2002, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[87]  F. Gruijl,et al.  Climate change and skin cancer. , 2002 .

[88]  J. Cadet,et al.  Formation of 2′-deoxyuridine hydrates upon exposure of nucleosides to gamma radiation and UVC-irradiation of isolated and cellular DNA , 2002, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[89]  L. Eriksson,et al.  Reaction mechanism of thymine dimer formation in DNA induced by UV light , 2002 .

[90]  K. Hemminki,et al.  How fast are UV-dimers repaired in human skin DNA in situ? , 2002, The Journal of investigative dermatology.

[91]  D. Yarosh,et al.  Measurement of UVB-Induced DNA damage and its consequences in models of immunosuppression. , 2002, Methods.

[92]  Jean Cadet,et al.  Radical Oxidation of the Adenine Moiety of Nucleoside and DNA: 2-Hydroxy-2′-deoxyadenosine is a Minor Decomposition Product , 2002, Free radical research.

[93]  P. Hanawalt,et al.  Ultraviolet-sensitive syndrome cells are defective in transcription-coupled repair of cyclobutane pyrimidine dimers. , 2002, DNA repair.

[94]  T. Ohtsuki,et al.  Identification and Characterization of an Intermediate in the Alkali Degradation of (6-4) Photoproduct-containing DNA* , 2003, Journal of Biological Chemistry.

[95]  P. To,et al.  DNA-protein cross-linking via guanine oxidation: dependence upon protein and photosensitizer. , 2003, Biochemistry.

[96]  L. Mullenders,et al.  Deficient global genome repair of UV-induced cyclobutane pyrimidine dimers in terminally differentiated myocytes and proliferating fibroblasts from the rat heart. , 2003, DNA repair.

[97]  J. Cadet,et al.  Formation of the spore photoproduct and other dimeric lesions between adjacent pyrimidines in UVC-irradiated dry DNA , 2003, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[98]  J. Cadet,et al.  Bipyrimidine photoproducts rather than oxidative lesions are the main type of DNA damage involved in the genotoxic effect of solar UVA radiation. , 2003, Biochemistry.

[99]  J. Cadet,et al.  Inter-strand photoproducts are produced in high yield within A-DNA exposed to UVC radiation. , 2003, Nucleic acids research.

[100]  E. Sage,et al.  UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells. , 2003, Nucleic acids research.

[101]  L. Eriksson,et al.  On the Formation of Cyclobutane Pyrimidine Dimers in UV‐irradiated DNA: Why are Thymines More Reactive? ¶ , 2003, Photochemistry and photobiology.

[102]  K. Hemminki,et al.  Effect of the spectral range of a UV lamp on the production of cyclobutane pyrimidine dimers in human skin in situ , 2003, Photodermatology, photoimmunology & photomedicine.

[103]  H. Griffiths,et al.  Immunochemical detection of UV-induced DNA damage and repair. , 2003, Journal of immunological methods.

[104]  J. Cadet,et al.  Oxidative damage to DNA: formation, measurement and biochemical features. , 2003, Mutation research.

[105]  D. Maes,et al.  Ultraviolet-B-induced oxidative DNA base damage in primary normal human epidermal keratinocytes and inhibition by a hydroxyl radical scavenger. , 2003, The Journal of investigative dermatology.

[106]  S. A. Snopov,et al.  Immunochemical study of DNA modifications in the nuclei of UV-damaged lymphocytes , 2004, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[107]  A. Favier,et al.  Predominance of the 1,N2-propano 2'-deoxyguanosine adduct among 4-hydroxy-2-nonenal-induced DNA lesions. , 2004, Free radical biology & medicine.

[108]  A. Sarasin,et al.  Trichothiodystrophy fibroblasts are deficient in the repair of ultraviolet-induced cyclobutane pyrimidine dimers and (6-4)photoproducts. , 2004, The Journal of investigative dermatology.

[109]  A. Favier,et al.  Singlet oxygen-mediated damage to cellular DNA determined by the comet assay associated with DNA repair enzymes , 2004, Biological chemistry.

[110]  E. Eveno,et al.  Differential Repair of the Two Major UV-Induced Photolesions in Trichothiodystrophy Fibroblasts , 2004, Cancer Research.

[111]  D. Johnston,et al.  Decreased Levels of (6-4) Photoproduct Excision Repair in Hybrid Fish of the Genus Xiphophorus¶ , 2004, Photochemistry and photobiology.

[112]  A. Favier,et al.  Unrepaired Cyclobutane Pyrimidine Dimers Do Not Prevent Proliferation of UV-B–irradiated Cultured Human Fibroblasts¶ , 2004 .

[113]  Yasuhiro Matsumura,et al.  Toxic effects of ultraviolet radiation on the skin. , 2004, Toxicology and applied pharmacology.

[114]  Toyotaka Ishibashi,et al.  DNA repair in higher plants; photoreactivation is the major DNA repair pathway in non-proliferating cells while excision repair (nucleotide excision repair and base excision repair) is active in proliferating cells. , 2004, Nucleic acids research.

[115]  J. Cadet,et al.  Mechanistic aspects of the oxidation of DNA constituents mediated by singlet molecular oxygen. , 2004, Archives of biochemistry and biophysics.

[116]  Jean Cadet,et al.  Effects of duplex stability on charge-transfer efficiency within DNA , 2004 .

[117]  R. Tyrrell,et al.  Ultraviolet a radiation-induced immediate iron release is a key modulator of the activation of NF-kappaB in human skin fibroblasts. , 2004, The Journal of investigative dermatology.

[118]  B. Gilchrest,et al.  Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice. , 2004, Proceedings of the National Academy of Sciences of the United States of America.