Risk levels for mite allergens. Are they meaningful?

Allergens found in house dust are among the most common environmental antigens to which man is naturally exposed. Standardized methods for measuring allergen exposure are essential for assessing the relationship between exposure, sensitization, and the severity of asthma. Monoclonal antibody‐based assays are the most widely used method for assessing allergen exposure. In the effort to define the best “index of exposure” to mite allergens, several factors need to be investigated, including:

[1]  M. Chapman,et al.  Airborne cat allergen (Fel d I). Environmental control with the cat in situ. , 1991, The American review of respiratory disease.

[2]  A. Custovic,et al.  House dust mite and cat allergen in different indoor environments , 1994, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[3]  S T Holgate,et al.  Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. , 1990, The New England journal of medicine.

[4]  M. Chapman,et al.  Environmental exposure to cockroach allergens: analysis with monoclonal antibody-based enzyme immunoassays. , 1991, The Journal of allergy and clinical immunology.

[5]  S. Lau,et al.  High mite-allergen exposure increases the risk of sensitization in atopic children and young adults. , 1989, The Journal of allergy and clinical immunology.

[6]  M. Chapman,et al.  The distribution of dust mite allergen in the houses of patients with asthma. , 1981, The American review of respiratory disease.

[7]  M. Chapman,et al.  Monoclonal antibodies to the major feline allergen Fel d I. II. Single step affinity purification of Fel d I, N-terminal sequence analysis, and development of a sensitive two-site immunoassay to assess Fel d I exposure. , 1988, Journal of immunology.

[8]  R. Voorhorst,et al.  The house-dust mite (Dermatophagoides pteronyssinus) and the allergens it produces. Identity with the house-dust allergen , 1967 .

[9]  P. Lind.  Enzyme‐Linked Immunosorbent Assay for Determination of Major Excrement Allergens of House Dust Mite Species D. pteronyssinus, D. farinae and D. microceras , 1986, Allergy.

[10]  M. Chapman.  Guanine – an adequate index of mite exposure? , 1993, Allergy.

[11]  J. Warner,et al.  Measurement of airborne mite antigen in homes of asthmatic children , 1990, The Lancet.

[12]  W. Thomas,et al.  Dust mite allergens and asthma: report of a second international workshop. , 1992, The Journal of allergy and clinical immunology.

[13]  Andrew M. Pope,et al.  Indoor Allergens—Assessing and Controlling Adverse Health Effects , 1993 .

[14]  P. Howarth,et al.  The control of allergens of dust mites and domestic pets: a position paper , 1992, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[15]  M. Chapman,et al.  Airborne dust mite allergens: comparison of group II allergens with group I mite allergen and cat-allergen Fel d I. , 1991, The Journal of allergy and clinical immunology.

[16]  A. Custovic,et al.  Evaluating exposure to mite allergens. , 1995, The Journal of allergy and clinical immunology.

[17]  Jens Korsgaard,et al.  Dust mite allergens and asthma--a worldwide problem. , 1989, The Journal of allergy and clinical immunology.

[18]  A. Woolcock,et al.  House dust mite allergens. A major risk factor for childhood asthma in Australia. , 1996, American journal of respiratory and critical care medicine.

[19]  H. Løwenstein,et al.  Assay for the major dog allergen, Can f I: investigation of house dust samples and commercial dog extracts. , 1991, The Journal of allergy and clinical immunology.

[20]  T Shida,et al.  Concentration of airborne mite allergens (Der I and Der II) during sleep , 1992, Allergy.

[21]  M. Lombardero,et al.  Monoclonal antibody based radioimmunoassay for the quantitation of the main cat allergen (Fel d I or Cat-1). , 1988, Journal of immunological methods.

[22]  Y. Li,et al.  Monoclonal antibodies to group II Dermatophagoides spp. allergens: murine immune response, epitope analysis, and development of a two-site ELISA. , 1994, The Journal of allergy and clinical immunology.

[23]  M. Klauck,et al.  Correlations between levels of mite and cat allergens in settled and airborne dust. , 1989, The Journal of allergy and clinical immunology.

[24]  M. Chapman,et al.  A two-site monoclonal antibody ELISA for the quantification of the major Dermatophagoides spp. allergens, Der p I and Der f I. , 1989, Journal of immunological methods.

[25]  J. Fox,et al.  Antigenic and structural analysis of group II allergens (Der f II and Der p II) from house dust mites (Dermatophagoides spp). , 1989, The Journal of allergy and clinical immunology.

[26]  A. Woodcock,et al.  Domestic allergens in public places II: dog (Can f 1) and cockroach (Bla g 2) allergens in dust and mite, cat, dog and cockroach allergens in the air in public buildings , 1996, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[27]  A. Woodcock,et al.  Aerodynamic properties of the major dog allergen Can f 1: distribution in homes, concentration, and particle size of allergen in the air. , 1997, American journal of respiratory and critical care medicine.

[28]  M. Chapman,et al.  Identification, quantitation, and purification of cockroach allergens using monoclonal antibodies. , 1991, The Journal of allergy and clinical immunology.

[29]  R. Aalberse,et al.  Monoclonal antibodies to the major feline allergen Fel d I. I. Serologic and biologic activity of affinity-purified Fel d I and of Fel d I-depleted extract. , 1988, The Journal of allergy and clinical immunology.

[30]  A. Woodcock,et al.  Exposure to house dust mite allergens and the clinical activity of asthma. , 1996, The Journal of allergy and clinical immunology.

[31]  S. Schraub,et al.  Mite allergen exposure is a risk for the incidence of specific sensitization. , 1994, The Journal of allergy and clinical immunology.

[32]  T Shida,et al.  Measurement of allergens associated with dust mite allergy. II. Concentrations of airborne mite allergens (Der I and Der II) in the house. , 1989, International archives of allergy and applied immunology.

[33]  H. Mita,et al.  Measurement of allergens associated with dust mite allergy. I. Development of sensitive radioimmunoassays for the two groups of Dermatophagoides mite allergens, Der I and Der II. , 1989, International archives of allergy and applied immunology.

[34]  M. Chapman,et al.  Airborne mite antigen , 1990, The Lancet.

[35]  R. Aalberse,et al.  Affinity purification of a major and a minor allergen from dog extract: serologic activity of affinity-purified Can f I and of Can f I-depleted extract. , 1991, The Journal of allergy and clinical immunology.

[36]  J J Cogswell,et al.  Development of IgE and IgG antibodies to food and inhalant allergens in children at risk of allergic disease. , 1985, Archives of disease in childhood.