Empagliflozin ameliorates endothelial dysfunction and suppresses atherogenesis in diabetic apolipoprotein E-deficient mice.
暂无分享,去创建一个
K. Hirata | K. Kusunose | M. Sata | M. Shinohara | D. Fukuda | H. Yamada | S. Yagi | T. Soeki | B. Ganbaatar | Byambasuren Ganbaatar
[1] H. Randeva,et al. Empagliflozin improves primary haemodynamic parameters and attenuates the development of atherosclerosis in high fat diet fed APOE knockout mice , 2019, Molecular and Cellular Endocrinology.
[2] R. Eckel,et al. Mechanism of Increased LDL (Low-Density Lipoprotein) and Decreased Triglycerides With SGLT2 (Sodium-Glucose Cotransporter 2) Inhibition , 2018, Arteriosclerosis, thrombosis, and vascular biology.
[3] H. Randeva,et al. Canagliflozin attenuates the progression of atherosclerosis and inflammation process in APOE knockout mice , 2018, Cardiovascular Diabetology.
[4] N. Chattipakorn,et al. Potential mechanisms responsible for cardioprotective effects of sodium–glucose co-transporter 2 inhibitors , 2018, Cardiovascular Diabetology.
[5] B. Zinman,et al. Empagliflozin reduces cardiovascular events, mortality and renal events in participants with type 2 diabetes after coronary artery bypass graft surgery: subanalysis of the EMPA-REG OUTCOME® randomised trial , 2018, Diabetologia.
[6] A. Murphy,et al. SGLT2 inhibition reduces atherosclerosis by enhancing lipoprotein clearance in Ldlr-/- type 1 diabetic mice. , 2018, Atherosclerosis.
[7] B. Zinman,et al. Cardiovascular Mortality Reduction With Empagliflozin in Patients With Type 2 Diabetes and Cardiovascular Disease. , 2018, Journal of the American College of Cardiology.
[8] L. Ghiadoni,et al. Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study , 2017, Cardiovascular Diabetology.
[9] K. Hirata,et al. Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B4 pathway by high-density lipoprotein in macrophages , 2017, Scientific Reports.
[10] T. Guzik,et al. Perivascular adipose tissue inflammation in vascular disease , 2017, British journal of pharmacology.
[11] J. Yudkin,et al. Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function , 2017, British journal of pharmacology.
[12] T. Asano,et al. The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice , 2017, International journal of molecular sciences.
[13] K. Lackner,et al. The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats , 2017, Redox biology.
[14] K. Mahaffey,et al. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes , 2017, The New England journal of medicine.
[15] Y. Higashikuni,et al. Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice. , 2017, Vascular pharmacology.
[16] A. Nishiyama,et al. Cardioprotective effects of SGLT2 inhibitors are possibly associated with normalization of the circadian rhythm of blood pressure , 2017, Hypertension Research.
[17] K. Park,et al. The beneficial effects of empagliflozin, an SGLT2 inhibitor, on atherosclerosis in ApoE−/− mice fed a western diet , 2017, Diabetologia.
[18] X. Ouyang,et al. The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE−/− Mice , 2016, Mediators of inflammation.
[19] Changwei Liu,et al. Perivascular adipose tissue alleviates inflammatory factors and stenosis in diabetic blood vessels. , 2016, Biochemical and biophysical research communications.
[20] M. Sata,et al. Glycemic Control with Ipragliflozin, a Novel Selective SGLT2 Inhibitor, Ameliorated Endothelial Dysfunction in Streptozotocin-Induced Diabetic Mouse , 2016, Front. Cardiovasc. Med..
[21] M. Pfeffer,et al. Lixisenatide in Type 2 Diabetes and Acute Coronary Syndrome. , 2016, The New England journal of medicine.
[22] J. L. Edwards. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. , 2016, The New England journal of medicine.
[23] B. Zinman,et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. , 2015, The New England journal of medicine.
[24] T. Hirano,et al. Amelioration of Hyperglycemia with a Sodium-Glucose Cotransporter 2 Inhibitor Prevents Macrophage-Driven Atherosclerosis through Macrophage Foam Cell Formation Suppression in Type 1 and Type 2 Diabetic Mice , 2015, PloS one.
[25] Y. Higashikuni,et al. Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice. , 2015, Atherosclerosis.
[26] S. Yamagishi,et al. Empagliflozin, an Inhibitor of Sodium-Glucose Cotransporter 2 Exerts Anti-Inflammatory and Antifibrotic Effects on Experimental Diabetic Nephropathy Partly by Suppressing AGEs-Receptor Axis , 2015, Hormone and Metabolic Research.
[27] T. Münzel,et al. The Sodium-Glucose Co-Transporter 2 Inhibitor Empagliflozin Improves Diabetes-Induced Vascular Dysfunction in the Streptozotocin Diabetes Rat Model by Interfering with Oxidative Stress and Glucotoxicity , 2014, PloS one.
[28] H. Koepsell,et al. Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia. , 2014, American journal of physiology. Renal physiology.
[29] C. Kim,et al. Resistin derived from diabetic perivascular adipose tissue up-regulates vascular expression of osteopontin via the AP-1 signalling pathway , 2013, The Journal of pathology.
[30] R. Webb,et al. Perivascular adipose tissue: more than just structural support. , 2012, Clinical science.
[31] P. Vanhoutte,et al. Endothelium‐mediated control of vascular tone: COX‐1 and COX‐2 products , 2011, British journal of pharmacology.
[32] Tetsuya Kitagawa,et al. Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue. , 2011, Journal of the American College of Cardiology.
[33] C. Sobey,et al. Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets , 2011, Nature Reviews Drug Discovery.
[34] R. M. Lee,et al. Alterations in perivascular adipose tissue structure and function in hypertension. , 2011, European journal of pharmacology.
[35] S. Narumiya,et al. Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies. , 2011, Pharmacology & therapeutics.
[36] M. Isobe,et al. Roles of prostaglandin E2 in cardiovascular diseases. , 2011, International heart journal.
[37] J. Badimón,et al. Prostanoid and TP-receptors in atherothrombosis: Is there a role for their antagonism? , 2010, Thrombosis and Haemostasis.
[38] M. Alloosh,et al. Epicardial Perivascular Adipose-Derived Leptin Exacerbates Coronary Endothelial Dysfunction in Metabolic Syndrome via a Protein Kinase C-&bgr; Pathway , 2010, Arteriosclerosis, thrombosis, and vascular biology.
[39] R. Henry,et al. SGLT2 inhibition — a novel strategy for diabetes treatment , 2010, Nature Reviews Drug Discovery.
[40] N. Weintraub,et al. Crosstalk between perivascular adipose tissue and blood vessels. , 2010, Current opinion in pharmacology.
[41] B. Jeppsson,et al. p38 Mitogen‐activated protein kinase signalling regulates vascular inflammation and epithelial barrier dysfunction in an experimental model of radiation‐induced colitis , 2010, The British journal of surgery.
[42] E. Dickson,et al. Proinflammatory Phenotype of Perivascular Adipocytes: Influence of High-Fat Feeding , 2009, Circulation research.
[43] R. M. Lee,et al. Effects of fetal and neonatal exposure to nicotine on blood pressure and perivascular adipose tissue function in adult life. , 2008, European journal of pharmacology.
[44] J. Stallone,et al. Sympathy for the devil: the role of thromboxane in the regulation of vascular tone and blood pressure. , 2008, American journal of physiology. Heart and circulatory physiology.
[45] O. Pedersen,et al. Effect of a multifactorial intervention on mortality in type 2 diabetes. , 2008, The New England journal of medicine.
[46] R. M. Lee,et al. Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide , 2007, British journal of pharmacology.
[47] N. Agrawal,et al. Atherosclerosis in diabetes mellitus: role of inflammation. , 2007, Indian journal of medical sciences.
[48] A. Koller,et al. Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus. , 2006, Pharmacological reports : PR.
[49] K. Schrör. Prostaglandins, other eicosanoids and endothelial cells , 1985, Basic Research in Cardiology.
[50] T. Imaizumi,et al. Advanced glycation end products (AGEs) and diabetic vascular complications. , 2005, Current diabetes reviews.
[51] P. Ganz,et al. Role of Endothelial Dysfunction in Atherosclerosis , 2004, Circulation.
[52] A. Manning,et al. Targeting JNK for therapeutic benefit: from junk to gold? , 2003, Nature Reviews Drug Discovery.
[53] P. Libby,et al. Diabetic macrovascular disease: the glucose paradox? , 2002, Circulation.
[54] A. Rigotti,et al. Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice. , 2001, Journal of lipid research.
[55] K. Kugiyama,et al. Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. , 1999, Journal of the American College of Cardiology.