Yeasts play a central role in industrial biotechnology and basic genetic research. Recently, we have seen an expansion of their traditional role in food and wine making to one of industrial chemical and protein production. This transition is, in part, enabled by a convergence of new capacities that have shaped the ability to rewire this organism. Namely, the past decade has seen genome sequence availability, cheap DNA synthesis, rapid assembly technologies and newfound capacity to understand synthetic parts and build these parts into complex pathways and circuits. Collectively, these capabilities …