A two-chamber model of valveless pumping using the immersed boundary method

Abstract We present a new mathematical model of valveless pumping for a tube with two elastic chambers, which is motivated by the Liebau’s two-tank model. The tube consists of partially soft and partially (almost) rigid and the periodic pumping is applied at an asymmetric location of the soft tube. The immersed boundary method is used to investigate the important characteristics of valveless pumping as the previous experiments and mathematical models have been discovered. We have observed the existence of a unidirectional mean flow and the dependence of mean flows on the frequency and the compression duration of the periodic pumping. We are able to explain the occurrence of local maximum or minimum mean flows due to the resonances of the system.

[1]  Charles S. Peskin,et al.  Simulations of the Whirling Instability by the Immersed Boundary Method , 2004, SIAM J. Sci. Comput..

[2]  Charles S. Peskin,et al.  Two-Dimensional Simulations of Valveless Pumping Using the Immersed Boundary Method , 2001, SIAM J. Sci. Comput..

[3]  Charles S. Peskin,et al.  Flow patterns around heart valves: a digital computer method for solving the equations of motion , 1973 .

[4]  Thomas T. Bringley,et al.  An experimental investigation and a simple model of a valveless pump , 2008 .

[5]  K. Rejniak A single-cell approach in modeling the dynamics of tumor microregions. , 2005, Mathematical biosciences and engineering : MBE.

[6]  Anna I Hickerson,et al.  Experimental study of the behavior of a valveless impedance pump , 2005 .

[7]  D. Mookherjee,et al.  Second virial coefficients of alkali vapours , 1976 .

[8]  Anna I Hickerson,et al.  On the resonance of a pliant tube as a mechanism for valveless pumping , 2006, Journal of Fluid Mechanics.

[9]  Rafael Beyar,et al.  Intrathoracic pressure fluctuations move blood during CPR: Comparison of hemodynamic data with predictions from a mathematical model , 2006, Annals of Biomedical Engineering.

[10]  C. Peskin,et al.  Fluid Dynamics of the Heart and its Valves , 1996 .

[11]  C. Peskin,et al.  A three-dimensional computational method for blood flow in the heart. 1. Immersed elastic fibers in a viscous incompressible fluid , 1989 .

[12]  S. Takagi,et al.  Study of a piston pump without valves (1st report, on a pipe-capacity-system with a T-junction) , 1983 .

[13]  J. P. Beyer A computational model of the cochlea using the immersed boundary method , 1992 .

[14]  J. Rosborough,et al.  The heart is a conduit in CPR. , 1981, Critical care medicine.

[15]  Eun-Sun Jung 2-D Simulations of Valveless Pumping Using the Immersed Boundary Method , 1999 .

[16]  A. Borzì,et al.  Numerical investigation of the Liebau phenomenon , 2003 .

[17]  Boyce E. Griffith,et al.  On the order of accuracy of the immersed boundary method: Higher order convergence rates for sufficiently smooth problems , 2005 .

[18]  Eunok Jung,et al.  A Mathematical Model of Valveless Pumping: A Lumped Model with Time-Dependent Compliance, Resistance, and Inertia , 2007, Bulletin of mathematical biology.

[19]  J. Ottesen,et al.  Molecular dynamics simulations of valveless pumping in a closed microfluidic tube-system , 2005 .

[20]  J. Ottesen,et al.  Valveless pumping in a fluid-filled closed elastic tube-system: one-dimensional theory with experimental validation , 2003, Journal of mathematical biology.

[21]  S. Takagi,et al.  Study of a Piston Pump without Valves : 2nd Report, Pumping Effect and Resonance in a Pipe-capacity-system with a T-junction , 1985 .

[22]  D. S. Mathioulakis,et al.  One-dimensional model of valveless pumping in a closed loop and a numerical solution , 2006 .

[23]  Eunok Jung,et al.  Computational models of valveless pumping using the immersed boundary method , 2008 .

[24]  J. Ottesen,et al.  Molecular dynamics simulations of oscillatory flows in microfluidic channels , 2006 .

[25]  Hans Thomann,et al.  A simple pumping mechanism in a valveless tube , 1978 .

[26]  G. Propst Pumping effects in models of periodically forced flow configurations , 2006 .

[27]  Gerhart Liebau,et al.  Über ein ventilloses Pumpprinzip , 2004, Naturwissenschaften.