Antibiotic Transport via Runoff and Soil Loss.

Research has verified the occurrence of veterinary antibiotics in manure, agricultural fields, and surface water bodies, yet little research has evaluated antibiotic runoff from agricultural fields. The objective of this study was to evaluate the potential for agricultural runoff to contribute antibiotics to surface water bodies in a worst-case scenario. Our hypothesis was that there would be significant differences in antibiotic concentrations, partitioning of losses between runoff and sediment, and pseudo-partitioning coefficients (ratio of sediment concentration to runoff concentration) among antibiotics. An antibiotic solution including tetracycline (TC), chlortetracycline (CTC), sulfathiazole (STZ), sulfamethazine (SMZ), erythromycin (ERY), tylosin (TYL), and monensin (MNS) was sprayed on the soil surface 1 h before rainfall simulation (average intensity = 60 mm h(-1) for 1 h). Runoff samples were collected continuously and analyzed for aqueous and sediment antibiotic concentrations. MNS had the highest concentration in runoff, resulting in the highest absolute loss, although the amount of loss associated with sediment transport was <10%. ERY had the highest concentrations in sediment and had a relative loss associated with sediment >50%. TYL also had >50% relative loss associated with sediment, and its pseudo-partitioning coefficient (P-PC) was very high. The tetracyclines (TC and CTC) had very low aqueous concentrations and had the lowest absolute losses. If agricultural runoff is proven to result in development of resistance genes or toxicity to aquatic organisms, then erosion control practices could be used to reduce TC, ERY, and TYL losses leaving agricultural fields. Other methods will be needed to reduce transport of other antibiotics.

[1]  K. Taylor,et al.  Particle size analysis , 2013 .

[2]  Linda S. Lee,et al.  Sorption of three tetracyclines by several soils: assessing the role of pH and cation exchange. , 2005, Environmental science & technology.

[3]  C. Stamm,et al.  Surface runoff and transport of sulfonamide antibiotics and tracers on manured grassland. , 2005, Journal of environmental quality.

[4]  A. Boxall,et al.  Column studies to investigate the fate of veterinary antibiotics in clay soils following slurry application to agricultural land. , 2005, Chemosphere.

[5]  A. Boxall,et al.  Transport of veterinary antibiotics in overland flow following the application of slurry to arable land. , 2005, Chemosphere.

[6]  R. Schulz,et al.  Test‐plot studies on runoff of sulfonamides from manured soils after sprinkler irrigation , 2005, Environmental toxicology and chemistry.

[7]  S. Thiele-Bruhn.  Microbial inhibition by pharmaceutical antibiotics in different soils—dose‐response relations determined with the iron(III) reduction test , 2005, Environmental toxicology and chemistry.

[8]  R. Kreuzig,et al.  Investigations on the fate of sulfadiazine in manured soil: Laboratory experiments and test plot studies , 2005, Environmental toxicology and chemistry.

[9]  E. Cortés,et al.  Organochlorine Concentrations in Bonnethead Sharks (Sphyrna tiburo) from Four Florida Estuaries , 2005, Archives of environmental contamination and toxicology.

[10]  A. Boxall,et al.  A lysimeter experiment to investigate the leaching of veterinary antibiotics through a clay soil and comparison with field data. , 2005, Environmental pollution.

[11]  T. Potter,et al.  Fluometuron and pendimethalin runoff from strip and conventionally tilled cotton in the southern atlantic coastal plain. , 2004, Journal of environmental quality.

[12]  Bent Halling-Sørensen,et al.  Simultaneous extraction of tetracycline, macrolide and sulfonamide antibiotics from agricultural soils using pressurised liquid extraction, followed by solid-phase extraction and liquid chromatography-tandem mass spectrometry. , 2004, Journal of chromatography. A.

[13]  Alistair B A Boxall,et al.  Fate of veterinary antibiotics in a macroporous tile drained clay soil , 2004, Environmental toxicology and chemistry.

[14]  Gerrit H. de Rooij,et al.  Methods of Soil Analysis. Part 4. Physical Methods , 2004 .

[15]  K. Müller,et al.  Herbicide loss in runoff: effects of herbicide properties, slope, and rainfall intensity , 2004 .

[16]  C. Truman,et al.  VARIABLE RAINFALL INTENSITY EFFECTS ON RUNOFF AND INTERRILL EROSION FROM TWO COASTAL PLAIN ULTISOLS IN GEORGIA , 2004 .

[17]  Jeffrey H Mandel,et al.  Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors. , 2003, Environmental health perspectives.

[18]  T. Potter,et al.  Cotton defoliant runoff as a function of active ingredient and tillage. , 2003, Journal of environmental quality.

[19]  K. Carlson,et al.  Evolution of antibiotic occurrence in a river through pristine, urban and agricultural landscapes. , 2003, Water research.

[20]  Christa S. McArdell,et al.  Occurrence and fate of macrolide antibiotics in wastewater treatment plants and in the Glatt Valley watershed, Switzerland. , 2003, Environmental science & technology.

[21]  A. Boxall,et al.  Are veterinary medicines causing environmental risks? , 2003, Environmental science & technology.

[22]  Sören Thiele-Bruhn,et al.  Pharmaceutical antibiotic compounds in soils – a review , 2003 .

[23]  Michael Spiteller,et al.  Determination of antibiotics such as macrolides, ionophores and tiamulin in liquid manure by HPLC–MS/MS , 2003, Analytical and bioanalytical chemistry.

[24]  M. Vigil,et al.  Nutrient variability in manures: Implications for sampling and regional database creation , 2002 .

[25]  Kathleen A. Smith,et al.  Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations. , 2002, The Science of the total environment.

[26]  R. Curini,et al.  An original approach to determining traces of tetracycline antibiotics in milk and eggs by solid-phase extraction and liquid chromatography/mass spectrometry. , 2002, Rapid communications in mass spectrometry : RCM.

[27]  B. Halling‐Sørensen,et al.  Determination of the distribution coefficient (log Kd) of oxytetracycline, tylosin A, olaquindox and metronidazole in manure. , 2002, Chemosphere.

[28]  A. Boxall,et al.  The sorption and transport of a sulphonamide antibiotic in soil systems. , 2002, Toxicology letters.

[29]  Christa S. McArdell,et al.  Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography-mass spectrometry. , 2002, Journal of chromatography. A.

[30]  H. Nau,et al.  Determination of persistent tetracycline residues in soil fertilized with liquid manure by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. , 2002, Analytical chemistry.

[31]  Craig D. Adams,et al.  Removal of Antibiotics from Surface and Distilled Water in Conventional Water Treatment Processes , 2002 .

[32]  D. Snow,et al.  Analysis of oxytetracycline, tetracycline, and chlortetracycline in water using solid-phase extraction and liquid chromatography-tandem mass spectrometry. , 2001, Journal of Chromatography A.

[33]  E. Thurman,et al.  Analysis of trace levels of sulfonamide and tetracycline antimicrobials in groundwater and surface water using solid-phase extraction and liquid chromatography/mass spectrometry. , 2001, Analytical chemistry.

[34]  P. L. Havens,et al.  Measurement and modeling of diclosulam runoff under the influence of simulated severe rainfall. , 2001, Journal of environmental quality.

[35]  N. H. Spliid,et al.  Sorption and mobility of metronidazole, olaquindox, oxytetracycline and tylosin in soil. , 2000, Chemosphere.

[36]  C. Lock,et al.  Rapid analysis of tetracycline antibiotics by combined solid phase microextraction/high performance liquid chromatography/mass spectrometry. , 1999, Rapid communications in mass spectrometry : RCM.

[37]  J. Hook,et al.  Surface transport of 2,4‐D from small turf plots: observations compared with GLEAMS and PRZM‐2 model simulations , 1999 .

[38]  M. B. Denton,et al.  Stability studies of tetracycline in methanol solution. , 1998, Journal of chromatography. A.

[39]  R. Leonard,et al.  LABORATORY DETERMINATION OF WATER AND PESTICIDE PARTITIONING1 , 1998 .

[40]  C. Lock,et al.  Electrospray ionization and collision-induced dissociation of antibiotic polyether ionophores. , 1998, Rapid communications in mass spectrometry : RCM.

[41]  B. Burgoa,et al.  Atrazine runoff and leaching losses from soil in tilted beds as influenced by three rates of lagoon effluent , 1993 .

[42]  R. Guy,et al.  Models for tetracycline in aquatic environments , 1987 .

[43]  R. Guy,et al.  Models for tetracycline in aquatic environments , 1987 .

[44]  G. J. Gascho,et al.  FENAMIPHOS LOSSES UNDER SIMULATED RAINFALL: PLOT SIZE EFFECTS , 2004 .

[45]  Y. R. Li,et al.  A pesticide runoff model for simulating runoff losses of pesticides from agricultural lands. , 2003, Water science and technology : a journal of the International Association on Water Pollution Research.

[46]  S. Jørgensen,et al.  Occurrence, fate and effects of pharmaceutical substances in the environment--a review. , 1998, Chemosphere.

[47]  D. Sparks,et al.  Methods of soil analysis. Part 3 - chemical methods. , 1996 .

[48]  J. B. Addison.  Antibiotics in sediments and run-off waters from feedlots. , 1984, Residue reviews.