Variable Furosemide Absorption and Poor Predictability of Response in Elderly Patients

Study Objectives. To determine the between‐ and within‐patient variability of furosemide bioavailability and natriuretic response, and whether four marketed products differ in bioavailability and response.

[1]  D. Brater Resistance to Loop Diuretics , 1985, Drugs.

[2]  J. Massarella,et al.  Disposition and absolute bioavailability of furosemide in healthy males. , 1982, Journal of pharmaceutical sciences.

[3]  M. Murray,et al.  Factors Contributing to Medication Noncompliance in Elderly Public Housing Tenants , 1986, Drug Intelligence & Clinical Pharmacy.

[4]  L. Benet,et al.  Absorption and disposition of furosemide in healthy volunteers, measured with a metabolite-specific assay. , 1980, Drug metabolism and disposition: the biological fate of chemicals.

[5]  Cockcroft Dw,et al.  Prediction of Creatinine Clearance from Serum Creatinine , 1976 .

[6]  S. Hall,et al.  Furosemide absorption in patients with cirrhosis , 1991, Clinical pharmacology and therapeutics.

[7]  N. Sambol Analysis of a Bioequivalence Trial Using Mixed Effects Modeling , 1995 .

[8]  K. L. Lipkind National Hospital Ambulatory Medical Care Survey: 1993 outpatient department summary. , 1995, Advance data.

[9]  D. Brater,et al.  The time course of delivery of furosemide into urine: an independent determinant of overall response. , 1982, Kidney international.

[10]  A. Straughn,et al.  Bioavailability of seven furosemide tablets in man. , 1986, Biopharmaceutics & drug disposition.

[11]  A. Ebihara,et al.  Chronopharmacological study of furosemide in human subjects. , 1987, International journal of clinical pharmacology research.

[12]  James P. Stevens,et al.  Power of the multivariate analysis of variance tests. , 1980 .