Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in Gout

In gout, autoinflammatory responses to urate crystals promote acute arthritis flares, but the pathogeneses of tophi, chronic synovitis, and erosion are less well understood. Defining the pathways of epigenomic immunity training can reveal novel pathogenetic factors and biomarkers. The present study was undertaken to seminally probe differential DNA methylation patterns utilizing epigenome‐wide analyses in patients with gout.

[1]  A. Saviano,et al.  IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation. , 2019, Pharmacological research.

[2]  E. Ballestar,et al.  Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis , 2019, Annals of the rheumatic diseases.

[3]  M. Brown,et al.  Best practices in DNA methylation: lessons from inflammatory bowel disease, psoriasis and ankylosing spondylitis , 2019, Arthritis Research & Therapy.

[4]  R. Terkeltaub,et al.  Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. , 2019, Cell metabolism.

[5]  Y. Bi,et al.  Metabolic regulation of inflammasomes in inflammation , 2019, Immunology.

[6]  C. Ling,et al.  Epigenetics in Human Obesity and Type 2 Diabetes , 2019, Cell metabolism.

[7]  N. Dalbeth,et al.  The anatomical pathology of gout: a systematic literature review , 2019, BMC Musculoskeletal Disorders.

[8]  Weiqi Wang,et al.  Taiji: System-level identification of key transcription factors reveals transcriptional waves in mouse embryonic development , 2019, Science Advances.

[9]  L. Joosten,et al.  Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host's Response to Pathogens. , 2019, Cell host & microbe.

[10]  Manel Esteller,et al.  Clinical epigenetics: seizing opportunities for translation , 2018, Nature Reviews Genetics.

[11]  F. Liu,et al.  NFATc3 Deficiency Reduces the Classical Activation of Adipose Tissue Macrophages. , 2018, Journal of molecular endocrinology.

[12]  P. Laird,et al.  SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions , 2018, Nucleic acids research.

[13]  M. Sperandio,et al.  Calcium signalling and related ion channels in neutrophil recruitment and function , 2018, European journal of clinical investigation.

[14]  T. Merriman,et al.  An update on the genetics of hyperuricaemia and gout , 2018, Nature Reviews Rheumatology.

[15]  M. Hughes,et al.  Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism , 2018, The Journal of Immunology.

[16]  D. Weeks,et al.  Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand , 2018, Diabetologia.

[17]  L. V. Van Laake,et al.  Circadian clocks: from stem cells to tissue homeostasis and regeneration , 2017, EMBO reports.

[18]  David J. Arenillas,et al.  JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework , 2017, Nucleic acids research.

[19]  A. Orekhov,et al.  The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2. , 2018, Immunobiology.

[20]  Hyon K. Choi,et al.  Effects of Febuxostat in Early Gout , 2017, Arthritis & rheumatology.

[21]  S. Duan,et al.  CCL2 promoter hypomethylation is associated with gout risk in Chinese Han male population. , 2017, Immunology letters.

[22]  C. Jun,et al.  NFAT1 Regulates Systemic Autoimmunity through the Modulation of a Dendritic Cell Property , 2017, The Journal of Immunology.

[23]  R. Terkeltaub.  What makes gouty inflammation so variable? , 2017, BMC Medicine.

[24]  J. Frič,et al.  Calcineurin–NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy , 2017, EMBO molecular medicine.

[25]  L. Joosten,et al.  Uric acid priming in human monocytes is driven by the AKT–PRAS40 autophagy pathway , 2017, Proceedings of the National Academy of Sciences.

[26]  T. Tamura,et al.  Transcriptional control of monocyte and macrophage development. , 2017, International immunology.

[27]  A. Gore,et al.  DNA methylation in hematopoietic development and disease. , 2016, Experimental hematology.

[28]  Yan Wang,et al.  Novel loci and pathways significantly associated with longevity , 2016, Scientific Reports.

[29]  Hirotaka Matsuo,et al.  Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes , 2015, Annals of the rheumatic diseases.

[30]  B. Viollet,et al.  AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages , 2014, Annals of the rheumatic diseases.

[31]  L. Joosten,et al.  Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout , 2015, Arthritis Research & Therapy.

[32]  A. Ogdie,et al.  2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative , 2015, Annals of the rheumatic diseases.

[33]  A. Ogdie,et al.  2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative , 2015, Annals of the rheumatic diseases.

[34]  P. Hawkins,et al.  PI3K signalling in inflammation. , 2015, Biochimica et biophysica acta.

[35]  Xuening Wang,et al.  1,25-Dihydroxyvitamin D3 induces monocytic differentiation of human myeloid leukemia cells by regulating C/EBPβ expression through MEF2C , 2015, The Journal of Steroid Biochemistry and Molecular Biology.

[36]  Hyon K. Choi,et al.  Nocturnal Risk of Gout Attacks , 2015, Arthritis & rheumatology.

[37]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[38]  E. Li,et al.  DNA methylation in mammals. , 2014, Cold Spring Harbor perspectives in biology.

[39]  Andrew E. Teschendorff,et al.  ChAMP: 450k Chip Analysis Methylation Pipeline , 2014, Bioinform..

[40]  S. M. Oliveira,et al.  Transient receptor potential ankyrin 1 receptor stimulation by hydrogen peroxide is critical to trigger pain during monosodium urate-induced inflammation in rodents. , 2013, Arthritis and rheumatism.

[41]  Fabian J Theis,et al.  Genome-wide association analyses identify 18 new loci associated with serum urate concentrations , 2012, Nature Genetics.

[42]  Martin J. Aryee,et al.  Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in Rheumatoid Arthritis , 2013, Nature Biotechnology.

[43]  Hyon K. Choi,et al.  Comorbidities of gout and hyperuricemia in the US general population: NHANES 2007-2008. , 2012, The American journal of medicine.

[44]  Devin C. Koestler,et al.  DNA methylation arrays as surrogate measures of cell mixture distribution , 2012, BMC Bioinformatics.

[45]  L. Stamp,et al.  Gout and Organ Transplantation , 2012, Current Rheumatology Reports.

[46]  O. Shaw,et al.  Bradykinin receptor 2 extends inflammatory cell recruitment in a model of acute gouty arthritis. , 2011, Biochemical and biophysical research communications.

[47]  Ralf Herwig,et al.  ConsensusPathDB: toward a more complete picture of cell biology , 2010, Nucleic Acids Res..

[48]  Jillian Cornish,et al.  Cellular characterization of the gouty tophus: a quantitative analysis. , 2010, Arthritis and rheumatism.

[49]  Mikael Bodén,et al.  Assigning roles to DNA regulatory motifs using comparative genomics , 2010, Bioinform..

[50]  Heike Bickeböller,et al.  Functional impact of endotoxin receptor CD14 polymorphisms on transcriptional activity , 2009, Journal of Molecular Medicine.

[51]  I. Reid,et al.  Enhanced osteoclastogenesis in patients with tophaceous gout: urate crystals promote osteoclast development through interactions with stromal cells. , 2008, Arthritis and rheumatism.

[52]  E. Olson,et al.  The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate. , 2008, Blood.

[53]  R. Terkeltaub,et al.  Engagement of CD14 Mediates the Inflammatory Potential of Monosodium Urate Crystals1 , 2006, The Journal of Immunology.

[54]  D. Mccarty,et al.  Preliminary criteria for the classification of the acute arthritis of primary gout. , 1977, Arthritis and rheumatism.