Wnt signaling regulates neural plate patterning in distinct temporal phases with dynamic transcriptional outputs.

[1]  D. Frank,et al.  New roles for Wnt and BMP signaling in neural anteroposterior patterning , 2019, EMBO reports.

[2]  R. Lovell-Badge,et al.  Nervous System Regionalization Entails Axial Allocation before Neural Differentiation , 2018, Cell.

[3]  A. Schug,et al.  Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates , 2018, eLife.

[4]  A. Regev,et al.  Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis , 2018, Science.

[5]  James A. Gagnon,et al.  Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain , 2018, Nature Biotechnology.

[6]  M. Hibi,et al.  Roles of maternal wnt8a transcripts in axis formation in zebrafish. , 2017, Developmental biology.

[7]  Holly C. Gibbs,et al.  Midbrain-Hindbrain Boundary Morphogenesis: At the Intersection of Wnt and Fgf Signaling , 2017, Front. Neuroanat..

[8]  R. Nusse,et al.  Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities , 2017, Cell.

[9]  A. Lekven,et al.  Vertebrate nervous system posteriorization: Grading the function of Wnt signaling , 2015, Developmental dynamics : an official publication of the American Association of Anatomists.

[10]  Claude Sinner,et al.  Filopodia-based Wnt transport during vertebrate tissue patterning , 2015, Nature Communications.

[11]  E. Jones,et al.  Extracellular modulators of Wnt signalling. , 2014, Current opinion in structural biology.

[12]  T. Blauwkamp,et al.  Wnt-Mediated Repression via Bipartite DNA Recognition by TCF in the Drosophila Hematopoietic System , 2014, PLoS genetics.

[13]  Annika Wylie,et al.  Post-transcriptional regulation of wnt8a is essential to zebrafish axis development. , 2014, Developmental biology.

[14]  A. Lekven,et al.  Biphasic wnt8a expression is achieved through interactions of multiple regulatory inputs , 2012, Developmental dynamics : an official publication of the American Association of Anatomists.

[15]  W. Weis,et al.  Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. , 2011, Developmental cell.

[16]  A. Lekven,et al.  A transgenic wnt8a:PAC reporter reveals biphasic regulation of vertebrate mesoderm development , 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

[17]  I. Schneider,et al.  Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. , 2010, Developmental biology.

[18]  A. Lekven,et al.  A direct role for Wnt8 in ventrolateral mesoderm patterning , 2010, Developmental dynamics : an official publication of the American Association of Anatomists.

[19]  M. Robinson,et al.  A scaling normalization method for differential expression analysis of RNA-seq data , 2010, Genome Biology.

[20]  M. Rhinn,et al.  Zebrafish gbx1 refines the Midbrain-Hindbrain Boundary border and mediates the Wnt8 posteriorization signal , 2009, Neural Development.

[21]  H. Theisen,et al.  Wingless Directly Represses DPP Morphogen Expression via an Armadillo/TCF/Brinker Complex , 2007, PloS one.

[22]  R. Moon,et al.  Distinct Wnt signaling pathways have opposing roles in appendage regeneration , 2006, Development.

[23]  Michael Brand,et al.  Lineage restriction maintains a stable organizer cell population at the zebrafish midbrain-hindbrain boundary , 2005, Development.

[24]  J. Ngai,et al.  The Sp1-Related Transcription Factors sp5 and sp5-like Act Downstream of Wnt/β-Catenin Signaling in Mesoderm and Neuroectoderm Patterning , 2005, Current Biology.

[25]  M. Rhinn,et al.  Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling , 2005, Development.

[26]  A. Lekven,et al.  Conservation of structure and functional divergence of duplicated Wnt8s in pufferfish , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[27]  A. Joyner,et al.  Cell Behaviors and Genetic Lineages of the Mesencephalon and Rhombomere 1 , 2004, Neuron.

[28]  M. Itoh,et al.  Exploring alternative models of rostral-caudal patterning in the zebrafish neurectoderm with computer simulations. , 2004, Current opinion in genetics & development.

[29]  C. Niehrs Regionally specific induction by the Spemann–Mangold organizer , 2004, Nature Reviews Genetics.

[30]  Arne C Lekven,et al.  Combinatorial Wnt control of zebrafish midbrain–hindbrain boundary formation , 2004, Mechanisms of Development.

[31]  S. Scholpp,et al.  Integrity of the midbrain region is required to maintain the diencephalic–mesencephalic boundary in zebrafish no isthmus/pax2.1 mutants , 2003, Developmental dynamics : an official publication of the American Association of Anatomists.

[32]  R. Moon,et al.  Two tcf3 genes cooperate to pattern the zebrafish brain , 2003, Development.

[33]  W. Driever,et al.  Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8 , 2003, Mechanisms of Development.

[34]  E. Fuchs,et al.  Links between signal transduction, transcription and adhesion in epithelial bud development , 2003, Nature.

[35]  Randall T Moon,et al.  Wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundary. , 2003, Developmental biology.

[36]  Hae-Chul Park,et al.  Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish. , 2002, Development.

[37]  Stephen W. Wilson,et al.  Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm. , 2002, Development.

[38]  Stephen W. Wilson,et al.  Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling , 2002, Neuron.

[39]  T. Jessell,et al.  Progressive induction of caudal neural character by graded Wnt signaling , 2002, Nature Neuroscience.

[40]  Choun-Ki Joo,et al.  Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway , 2002, Molecular and Cellular Biology.

[41]  A. Joyner,et al.  Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression. , 2001, Development.

[42]  C. Niehrs,et al.  A morphogen gradient of Wnt/beta-catenin signalling regulates anteroposterior neural patterning in Xenopus. , 2001, Development.

[43]  C. Wright,et al.  Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. , 2001, Development.

[44]  R. Moon,et al.  Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning. , 2001, Developmental cell.

[45]  A. Joyner,et al.  Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer. , 2000, Current opinion in cell biology.

[46]  Wolfgang Driever,et al.  Repressor activity of Headless/Tcf3 is essential for vertebrate head formation , 2000, Nature.

[47]  H. Jäckle,et al.  Drosophila segment borders result from unilateral repression of hedgehog activity by wingless signaling. , 2000, Molecular cell.

[48]  A. Simeone,et al.  Positioning the isthmic organizer where Otx2 and Gbx2meet. , 2000, Trends in genetics : TIG.

[49]  Alexandra L. Joyner,et al.  A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer , 1999, Nature.

[50]  R. Moon,et al.  Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus , 1999, Mechanisms of Development.

[51]  J. Nathans,et al.  Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[52]  R. Moon,et al.  Wnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus , 1997, Mechanisms of Development.

[53]  L. Zon,et al.  The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. , 1997, Development.

[54]  A. Joyner,et al.  Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. , 1997, Development.

[55]  Andrew P. McMahon,et al.  Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development , 1996, Nature.

[56]  A. Hemmati-Brivanlou,et al.  Caudalization of neural fate by tissue recombination and bFGF. , 1995, Development.

[57]  R. Moon,et al.  Specification of the anteroposterior neural axis through synergistic interaction of the Wnt signaling cascade with noggin and follistatin. , 1995, Developmental biology.

[58]  S. Aizawa,et al.  Mouse Otx2 functions in the formation and patterning of rostral head. , 1995, Genes & development.

[59]  R. Moon,et al.  Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways. , 1995, Development.

[60]  Andrew P. McMahon,et al.  The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain , 1990, Cell.

[61]  Mario R. Capecchi,et al.  Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development , 1990, Nature.

[62]  H. Hendriks,et al.  Retinoic acid causes an anteroposterior transformation in the developing central nervous system , 1989, Nature.

[63]  P. Nieuwkoop Activation and organization of the central nervous system in amphibians.† Part I. Induction and activation , 1952 .

[64]  P. Greengard,et al.  Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor , 2004, Nature Medicine.

[65]  Alex E. Lash,et al.  Gene Expression Omnibus: NCBI gene expression and hybridization array data repository , 2002, Nucleic Acids Res..

[66]  M. Westerfield The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio) , 1995 .