Molecular genetic studies of gene identification for sarcopenia

[1]  S. Davis,et al.  Androgen Replacement Therapy in Androgen-Deficient Women with Hypopituitarism , 2012, Drugs.

[2]  Matthew A. Kostek,et al.  The Role of Genetic Variation in Muscle Strength , 2011 .

[3]  L. Ferrucci,et al.  Comprehensive fine mapping of chr12q12-14 and follow-up replication identify activin receptor 1B (ACVR1B) as a muscle strength gene , 2011, European Journal of Human Genetics.

[4]  A. Lucia,et al.  The K153R Polymorphism in the Myostatin Gene and Muscle Power Phenotypes in Young, Non-Athletic Men , 2011, PloS one.

[5]  D. Allen,et al.  Posttranscriptional mechanisms involving microRNA-27a and b contribute to fast-specific and glucocorticoid-mediated myostatin expression in skeletal muscle. , 2011, American journal of physiology. Cell physiology.

[6]  S. Roth,et al.  ACE and ACTN3 Genotypes in Older Women: Muscular Phenotypes , 2010, International journal of sports medicine.

[7]  B. Léger,et al.  Antibody‐directed myostatin inhibition in 21‐mo‐old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  A. Lucia,et al.  Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults? , 2010, European Journal of Applied Physiology.

[9]  J. Baeyens,et al.  Sarcopenia: European consensus on definition and diagnosis , 2010, Age and ageing.

[10]  C. Hagen,et al.  The impact of the CAG repeat polymorphism of the androgen receptor gene on muscle and adipose tissues in 20-29-year-old Danish men: Odense Androgen Study. , 2010, European journal of endocrinology.

[11]  G. Biolo,et al.  Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics". , 2010, Clinical nutrition.

[12]  W. Evans,et al.  Skeletal muscle loss: cachexia, sarcopenia, and inactivity. , 2010, The American journal of clinical nutrition.

[13]  A. Lucia,et al.  The K153R variant in the myostatin gene and sarcopenia at the end of the human lifespan , 2010, AGE.

[14]  A. Lucia,et al.  ACE and ACTN3 Genes and Muscle Phenotypes in Nonagenarians , 2010, International journal of sports medicine.

[15]  S. Kuno,et al.  ACTN3 Polymorphism Affects Thigh Muscle Area , 2009, International journal of sports medicine.

[16]  J. Baeyens,et al.  European working group on sarcopenia in older people. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people , 2010 .

[17]  D. Felsenberg,et al.  Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power: results from two independent studies (APOSS and OPUS) , 2010, Osteoporosis International.

[18]  S. Mastana,et al.  ACE I/D and ACTN3 R/X polymorphisms and muscle function and muscularity of older Caucasian men , 2010, European Journal of Applied Physiology.

[19]  K. North,et al.  Sarcomeric α-actinins and their role in human muscle disease , 2009 .

[20]  P. Fasanaro,et al.  Microrna-221 and Microrna-222 Modulate Differentiation and Maturation of Skeletal Muscle Cells , 2009, PloS one.

[21]  M. Visser,et al.  Towards a definition of sarcopenia — results from epidemiologic studies , 2009, The journal of nutrition, health & aging.

[22]  E. Hoffman,et al.  CNTF 1357 G -> A polymorphism and the muscle strength response to resistance training. , 2009, Journal of applied physiology.

[23]  Ana Cumano,et al.  Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression , 2009, Proceedings of the National Academy of Sciences.

[24]  I. Ara,et al.  Androgen receptor gene polymorphisms lean mass and performance in young men , 2009, British Journal of Sports Medicine.

[25]  Y. Meckel,et al.  ACTN3 R577X Polymorphism and Israeli Top-level Athletes , 2009, International journal of sports medicine.

[26]  D. Guttridge,et al.  MicroRNAs: Novel components in a muscle gene regulatory network , 2009, Cell Cycle.

[27]  R. Newton,et al.  Reduced muscle strength and functional performance in men with prostate cancer undergoing androgen suppression: a comprehensive cross-sectional investigation , 2009, Prostate Cancer and Prostatic Diseases.

[28]  S. Hatakeyama,et al.  Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size. , 2009, American journal of physiology. Cell physiology.

[29]  A. Yoshihara,et al.  Physical Function Is Weakly Associated with Angiotensin-Converting Enzyme Gene I/D Polymorphism in Elderly Japanese Subjects , 2009, Gerontology.

[30]  G. Vona,et al.  Association between the ACTN3 R577X polymorphism and artistic gymnastic performance in Italy. , 2009, Genetic testing and molecular biomarkers.

[31]  F. G. Rodriguez-Gonzalez,et al.  Androgen Receptor Gene Repeat Polymorphism, Leptin And Fat Mass In Young Men And Women: 2969 , 2009 .

[32]  Matthew A. Kostek,et al.  Myostatin and follistatin polymorphisms interact with muscle phenotypes and ethnicity. , 2009, Medicine and science in sports and exercise.

[33]  J. Kaprio,et al.  Genetic and environmental effects on isometric muscle strength and leg extensor power followed up for three years among older female twins. , 2009, Journal of applied physiology.

[34]  J. Hawley.  Molecular responses to strength and endurance training: are they incompatible? , 2009, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[35]  D. Kiel,et al.  Bivariate Genome‐Wide Linkage Analysis of Femoral Bone Traits and Leg Lean Mass: Framingham Study , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[36]  A. Vigano,et al.  Relationship Between Angiotensin-Converting Enzyme Gene Polymorphism and Body Composition, Functional Performance, and Blood Biomarkers in Advanced Cancer Patients , 2009, Clinical Cancer Research.

[37]  S. Levy,et al.  Genome-wide association and replication studies identified TRHR as an important gene for lean body mass. , 2009, American journal of human genetics.

[38]  Yan Guo,et al.  Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. , 2009, American journal of human genetics.

[39]  J. Hawley,et al.  Global gene expression in skeletal muscle from well-trained strength and endurance athletes. , 2009, Medicine and science in sports and exercise.

[40]  P. Tesch,et al.  Strength, power, fiber types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes. , 2009, Journal of applied physiology.

[41]  L. Schook,et al.  Age and Diet Affect Gene Expression Profile in Canine Skeletal Muscle , 2009, PloS one.

[42]  J. Kaprio,et al.  Muscle Cross‐Sectional Area and Structural Bone Strength Share Genetic and Environmental Effects in Older Women , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[43]  Y. Duan,et al.  Cyclic stretch induced miR-146a upregulation delays C2C12 myogenic differentiation through inhibition of Numb. , 2009, Biochemical and biophysical research communications.

[44]  Sanjiv J. Shah,et al.  Whole-genome association study identifies STK39 as a hypertension susceptibility gene , 2009, Proceedings of the National Academy of Sciences.

[45]  S. Mastana,et al.  Human angiotensin‐converting enzyme I/D and α‐actinin 3 R577X genotypes and muscle functional and contractile properties , 2009, Experimental physiology.

[46]  K. North,et al.  alpha-actinin-3 and performance. , 2009, Medicine and sport science.

[47]  K. Esser,et al.  Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids. , 2008, American journal of physiology. Endocrinology and metabolism.

[48]  Huating Wang,et al.  NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. , 2008, Cancer cell.

[49]  J. Cauley,et al.  Association of the ACTN3 Genotype and Physical Functioning With Age in Older Adults , 2008 .

[50]  L. Ferrucci,et al.  ACTN3 genotype is associated with muscle phenotypes in women across the adult age span. , 2008, Journal of applied physiology.

[51]  E. Pistilli,et al.  Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading. , 2008, Journal of applied physiology.

[52]  G. Beunen,et al.  Genome-wide linkage scan for contraction velocity characteristics of knee musculature in the Leuven Genes for Muscular Strength Study. , 2008, Physiological genomics.

[53]  L. Ferrucci,et al.  TNF promoter polymorphisms associated with muscle phenotypes in humans. , 2008, Journal of applied physiology.

[54]  A. Harrison,et al.  Aging thyroarytenoid and limb skeletal muscle: lessons in contrast. , 2008, Journal of voice : official journal of the Voice Foundation.

[55]  G. Onder,et al.  Vitamin D Receptor Polymorphisms and Falls Among Older Adults Living in the Community: Results From the ilSIRENTE Study , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[56]  K. Mohlke,et al.  Association of FTO With Obesity-Related Traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort , 2008, Diabetes.

[57]  M. Perola,et al.  Genetics of Maximal Walking Speed and Skeletal Muscle Characteristics in Older Women , 2008, Twin Research and Human Genetics.

[58]  D. Kiel,et al.  Genetics of the Musculoskeletal System: A Pleiotropic Approach , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[59]  D. MacArthur,et al.  An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance. , 2008, Human molecular genetics.

[60]  Chung F. Wong,et al.  MicroRNA-26a Targets the Histone Methyltransferase Enhancer of Zeste homolog 2 during Myogenesis* , 2008, Journal of Biological Chemistry.

[61]  B. Hurley,et al.  ACE genotype and the muscle hypertrophic and strength responses to strength training. , 2008, Medicine and science in sports and exercise.

[62]  A. Russell,et al.  Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation. , 2008, Rejuvenation research.

[63]  S. Humphries,et al.  Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary disease. , 2008, The American journal of clinical nutrition.

[64]  C. Peterson,et al.  Aging alters gene expression of growth and remodeling factors in human skeletal muscle both at rest and in response to acute resistance exercise. , 2008, Physiological genomics.

[65]  G. Beunen,et al.  Genome-wide linkage scan for maximum and length-dependent knee muscle strength in young men: significant evidence for linkage at chromosome 14q24.3 , 2008, Journal of Medical Genetics.

[66]  Yao-Zhong Liu,et al.  Bivariate Whole Genome Linkage Analyses for Total Body Lean Mass and BMD , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[67]  E. Bleecker,et al.  Interaction between Angiotensin Converting Enzyme Insertion/Deletion Genotype and Exercise Training on Knee Extensor Strength in Older Individuals , 2007, International journal of sports medicine.

[68]  R. Recker,et al.  The MTHFR gene polymorphism is associated with lean body mass but not fat body mass , 2008, Human Genetics.

[69]  Y. Meckel,et al.  ACE ID genotype affects blood creatine kinase response to eccentric exercise. , 2007, Journal of applied physiology.

[70]  P. Hespel,et al.  ACTN3 (R577X) genotype is associated with fiber type distribution. , 2007, Physiological genomics.

[71]  E. Olson,et al.  Skeletal muscle remodeling , 2007, Current opinion in rheumatology.

[72]  James M Hagberg,et al.  Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults. , 2007, Journal of applied physiology.

[73]  R. Griffiths,et al.  The role of hormones, cytokines and heat shock proteins during age-related muscle loss. , 2007, Clinical nutrition.

[74]  D. MacArthur,et al.  Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans , 2007, Nature Genetics.

[75]  C. Bunker,et al.  Genetic and environmental influences on skeletal muscle phenotypes as a function of age and sex in large, multigenerational families of African heritage. , 2007, Journal of applied physiology.

[76]  D. Grattapaglia,et al.  Lack of association between vitamin D receptor genotypes and haplotypes with fat-free mass in postmenopausal Brazilian women. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[77]  T. Spector,et al.  Linkage of genes to total lean body mass in normal women. , 2007, The Journal of clinical endocrinology and metabolism.

[78]  P. Xiao,et al.  Bivariate Whole Genome Linkage Analysis for Femoral Neck Geometric Parameters and Total Body Lean Mass , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[79]  L. Ferrucci,et al.  Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. , 2007, Journal of applied physiology.

[80]  Alan Hubbard,et al.  Resistance Exercise Reverses Aging in Human Skeletal Muscle , 2007, PloS one.

[81]  J. Lefevre,et al.  Polymorphisms in the CNTF and CNTF receptor genes are associated with muscle strength in men and women. , 2007, Journal of applied physiology.

[82]  J. Lefevre,et al.  Polymorphisms in the vitamin D receptor gene are associated with muscle strength in men and women , 2007, Osteoporosis International.

[83]  C. Christiansen,et al.  Leptin Receptor Genotype at Gln223Arg is Associated With Body Composition, BMD, and Vertebral Fracture in Postmenopausal Danish Women , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[84]  J. Kaufman,et al.  Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men? , 2007, European journal of endocrinology.

[85]  M. Yoshioka,et al.  Gene expression profile of sprinter's muscle. , 2007, International journal of sports medicine.

[86]  E. Hoffman,et al.  Resistin Polymorphisms Are Associated with Muscle, Bone, and Fat Phenotypes in White Men and Women , 2007, Obesity.

[87]  N. A. Doldo,et al.  Alpha-actinin-3 (ACTN3) R577X polymorphism influences knee extensor peak power response to strength training in older men and women. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[88]  K. Esser,et al.  MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy. , 2007, Journal of applied physiology.

[89]  G. Hunter,et al.  IGF-I polymorphism is associated with lean mass, exercise economy, and exercise performance among premenopausal women. , 2007, Archives of medical research.

[90]  Hui Shen,et al.  A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families , 2007, Human Genetics.

[91]  Stanley Heshka,et al.  Total-body skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in children and adolescents. , 2006, The American journal of clinical nutrition.

[92]  R. Werner,et al.  MIR-206 regulates connexin43 expression during skeletal muscle development , 2006, Nucleic acids research.

[93]  S. Tapscott,et al.  MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206 , 2006, The Journal of cell biology.

[94]  Martin Sust,et al.  Biomechanical muscle properties and angiotensin-converting enzyme gene polymorphism: a model-based study , 2006, European Journal of Applied Physiology.

[95]  A. Malhotra,et al.  Muscle-specific microRNA miR-206 promotes muscle differentiation , 2006, The Journal of cell biology.

[96]  S. Bandinelli,et al.  Axonal degeneration affects muscle density in older men and women , 2006, Neurobiology of Aging.

[97]  Kevin G Becker,et al.  Transcriptional Profiling of Aging in Human Muscle Reveals a Common Aging Signature , 2006, PLoS genetics.

[98]  Harvey F Lodish,et al.  Myogenic factors that regulate expression of muscle-specific microRNAs. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[99]  Florian Caiment,et al.  A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep , 2006, Nature Genetics.

[100]  R. Blumenthal,et al.  Therapy Insight: managing cardiovascular risk in patients with rheumatoid arthritis , 2006, Nature Clinical Practice Rheumatology.

[101]  Matthew A. Kostek,et al.  ACE ID genotype and the muscle strength and size response to unilateral resistance training. , 2006, Medicine and science in sports and exercise.

[102]  D. Clayton,et al.  A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region , 2006, Nature Genetics.

[103]  A. Chakravarti,et al.  Variation in the Ciliary Neurotrophic Factor Gene and Muscle Strength in Older Caucasian Women , 2006, Journal of the American Geriatrics Society.

[104]  F. Hu,et al.  A Common Genetic Variant Is Associated with Adult and Childhood Obesity , 2006, Science.

[105]  J. Reecy,et al.  Gene expression profiling: insights into skeletal muscle growth and development. , 2006, Journal of animal science.

[106]  A. Tsiokanos,et al.  The associations of ACE polymorphisms with physical, physiological and skill parameters in adolescents , 2006, European Journal of Human Genetics.

[107]  Annick Harel-Bellan,et al.  The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation , 2006, Nature Cell Biology.

[108]  B. Levkau,et al.  Degraded collagen induces calpain-mediated apoptosis and destruction of the X-chromosome-linked inhibitor of apoptosis (xIAP) in human vascular smooth muscle cells. , 2006, Cardiovascular research.

[109]  Jian-Fu Chen,et al.  The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation , 2006, Nature Genetics.

[110]  I. Janssen.  Influence of Sarcopenia on the Development of Physical Disability: The Cardiovascular Health Study , 2006, Journal of the American Geriatrics Society.

[111]  Wang Hy,et al.  Association between Polymorphisms of Vitamin D Receptor Gene ApaI, BsmI and TaqI and Muscular Strength in Young Chinese Women , 2005, International journal of sports medicine.

[112]  P. McCrory.  The end of the beginning. , 2006, British journal of sports medicine.

[113]  G. Vogler,et al.  Genetic determinants of weight of fast- and slow-twitch skeletal muscles in old mice , 2006, Mammalian Genome.

[114]  A. Lucia,et al.  Does complete deficiency of muscle α actinin 3 alter functional capacity in elderly women? A preliminary report , 2005, British Journal of Sports Medicine.

[115]  M. Matzuk,et al.  Regulation of muscle growth by multiple ligands signaling through activin type II receptors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[116]  D. Glass,et al.  Skeletal muscle hypertrophy and atrophy signaling pathways. , 2005, The international journal of biochemistry & cell biology.

[117]  V. Ambros,et al.  Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth. , 2005, Genes & development.

[118]  D. Duggan,et al.  Recent developments in genomewide association scans: a workshop summary and review. , 2005, American journal of human genetics.

[119]  G. Zhai,et al.  The genetic contribution to longitudinal changes in knee structure and muscle strength: a sibpair study. , 2005, Arthritis and rheumatism.

[120]  M. Tarnopolsky,et al.  The FASEB Journal express article 10.1096/fj.04-3149fje. Published online June 28, 2005. Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise , 2022 .

[121]  G. Beunen,et al.  Quantitative trait loci for human muscle strength: linkage analysis of myostatin pathway genes. , 2005, Physiological genomics.

[122]  S. Rubin,et al.  Angiotensin-converting enzyme insertion/deletion genotype, exercise, and physical decline. , 2005, JAMA.

[123]  A. Petrie,et al.  Stem Cell Function, Self-Renewal, and Behavioral Heterogeneity of Cells from the Adult Muscle Satellite Cell Niche , 2005, Cell.

[124]  E. Hoffman,et al.  ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women. , 2005, Journal of applied physiology.

[125]  C. Bouchard,et al.  Endurance training-induced changes in insulin sensitivity and gene expression. , 2005, American journal of physiology. Endocrinology and metabolism.

[126]  L. Douglass,et al.  Muscle strength response to strength training is influenced by insulin-like growth factor 1 genotype in older adults. , 2005, Journal of applied physiology.

[127]  Claes Wahlestedt,et al.  Considerations when using the significance analysis of microarrays (SAM) algorithm , 2005, BMC Bioinformatics.

[128]  T. Prolla,et al.  Gene expression profiling studies of aging in cardiac and skeletal muscles. , 2005, Cardiovascular research.

[129]  Claes Wahlestedt,et al.  Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[130]  G. Mcclearn,et al.  Genetic determinants of weight of fast- and slow-twitch skeletal muscle in 500-day-old mice of the C57BL/6J and DBA/2J lineage. , 2005, Physiological genomics.

[131]  P. Giresi,et al.  Identification of a molecular signature of sarcopenia. , 2005, Physiological genomics.

[132]  L. Ferrucci,et al.  IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women , 2005, Experimental Gerontology.

[133]  H. Lodish,et al.  MicroRNAs as regulators of mammalian hematopoiesis. , 2005, Seminars in immunology.

[134]  E. Grundberg,et al.  A TA-repeat polymorphism in the gene for the estrogen receptor alpha does not correlate with muscle strength or body composition in young adult Swedish women. , 2005, Maturitas.

[135]  Zhijian Lu,et al.  Regulation of GDF-8 signaling by the p38 MAPK. , 2005, Cellular signalling.

[136]  J. Woo,et al.  Prevalence of and risk factors for sarcopenia in elderly Chinese men and women. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[137]  K. Lohman,et al.  Heritability of body composition measured by DXA in the diabetes heart study. , 2005, Obesity research.

[138]  D. McGee,et al.  Lack of Association Between Androgen Receptor Polymorphisms and Bone Mineral Density or Physical Function in Older Men , 2005, Endocrine research.

[139]  P. Delmas,et al.  Low Skeletal Muscle Mass Is Associated With Poor Structural Parameters of Bone and Impaired Balance in Elderly Men—The MINOS Study , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[140]  C. Leeuwenburgh,et al.  The Role of Apoptosis in Age-Related Skeletal Muscle Atrophy , 2005, Sports medicine.

[141]  J. Kaprio,et al.  Shared genetic and environmental effects on strength and power in older female twins. , 2005, Medicine and science in sports and exercise.

[142]  J. Folland,et al.  Circulating angiotensin converting enzyme activity is correlated with muscle strength. , 2005, Medicine and science in sports and exercise.

[143]  E. Metter,et al.  Androgen receptor CAG repeat polymorphism is associated with fat-free mass in men. , 2005, Journal of applied physiology.

[144]  A quantitative trait locus on 13q14.2 for trunk strength. , 2004, Twin research : the official journal of the International Society for Twin Studies.

[145]  Xiangding Chen,et al.  Lack of evidence for a major gene in the Mendelian transmission of BMI in Chinese. , 2004, Obesity research.

[146]  E. Metter,et al.  Insulin-like growth factor-2 genotype, fat-free mass, and muscle performance across the adult life span. , 2004, Journal of applied physiology.

[147]  G. Lyons,et al.  The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. , 2004, Genes & development.

[148]  E. Hawe,et al.  Angiotensin converting enzyme genotype and strength in chronic obstructive pulmonary disease. , 2004, American journal of respiratory and critical care medicine.

[149]  H. Kemper,et al.  The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults. , 2004, The Journal of clinical endocrinology and metabolism.

[150]  S. Heymsfield,et al.  Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults. , 2004, Journal of applied physiology.

[151]  D. Panagiotakos,et al.  The IL-6 gene G-174C polymorphism related to health indices in Greek primary school children. , 2004, Obesity research.

[152]  R. Roubenoff.  Sarcopenic obesity: the confluence of two epidemics. , 2004, Obesity research.

[153]  G. Beunen,et al.  Linkage of myostatin pathway genes with knee strength in humans. , 2004, Physiological genomics.

[154]  J. Long,et al.  Tests of linkage and/or association of the LEPR gene polymorphisms with obesity phenotypes in Caucasian nuclear families. , 2004, Physiological genomics.

[155]  C. Bouchard,et al.  Exploration of myostatin polymorphisms and the angiotensin-converting enzyme insertion/deletion genotype in responses of human muscle to strength training , 2004, European Journal of Applied Physiology.

[156]  G. Beunen,et al.  Determinants and upper-limit heritabilities of skeletal muscle mass and strength. , 2004, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[157]  G. Zhai,et al.  The genetic contribution to muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis: a sibpair study. , 2004, Arthritis and rheumatism.

[158]  Stephen Welle,et al.  Skeletal muscle gene expression profiles in 20–29 year old and 65–71 year old women , 2004, Experimental Gerontology.

[159]  E. Grundberg,et al.  Genetic variation in the human vitamin D receptor is associated with muscle strength, fat mass and body weight in Swedish women. , 2004, European journal of endocrinology.

[160]  R. Billeter,et al.  Regulatory gene expression in skeletal muscle of highly endurance-trained humans. , 2004, Acta physiologica Scandinavica.

[161]  Ronenn Roubenoff,et al.  The Healthcare Costs of Sarcopenia in the United States , 2004, Journal of the American Geriatrics Society.

[162]  W. Ettinger,et al.  Excitation-calcium release uncoupling in aged single human skeletal muscle fibers , 1995, The Journal of Membrane Biology.

[163]  J. Kaprio,et al.  Heritability of maximal isometric muscle strength in older female twins. , 2004, Journal of applied physiology.

[164]  J. Cauley,et al.  Vitamin D receptor genotype is associated with fat-free mass and sarcopenia in elderly men. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[165]  V. Ambros,et al.  Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation , 2004, Genome Biology.

[166]  G. Mcclearn,et al.  Genetic architecture of fast- and slow-twitch skeletal muscle weight in 200-day-old mice of the C57BL/6J and DBA/2J lineage. , 2003, Physiological genomics.

[167]  C. Auffray,et al.  Gene expression profiling of human satellite cells during muscular aging using cDNA arrays. , 2003, Gene.

[168]  E. Metter,et al.  Interleukin-6 (IL6) genotype is associated with fat-free mass in men but not women. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[169]  S. Rubin,et al.  Sarcopenia: Alternative Definitions and Associations with Lower Extremity Function , 2003, Journal of the American Geriatrics Society.

[170]  J. Souberbielle,et al.  Insulin-like growth factor I correlates with lean body mass in cystic fibrosis patients , 2003, Archives of disease in childhood.

[171]  J. Wrana,et al.  Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis , 2003, Molecular and Cellular Biology.

[172]  E. Snyder,et al.  Serial analysis of gene expression in the skeletal muscle of endurance athletes compared to sedentary men , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[173]  A. Kuroiwa,et al.  Hoxa‐11 and Hoxa‐13 are involved in repression of MyoD during limb muscle development , 2003, Development, growth & differentiation.

[174]  F. Booth,et al.  Transcriptional profiling identifies extensive downregulation of extracellular matrix gene expression in sarcopenic rat soleus muscle. , 2003, Physiological genomics.

[175]  K. Christensen,et al.  ACE genotype and physical training effects: A randomized study among elderly Danes , 2003, Aging clinical and experimental research.

[176]  Stephen Welle,et al.  Gene expression profile of aging in human muscle. , 2003, Physiological genomics.

[177]  Alun Jones,et al.  Skeletal muscle RAS and exercise performance. , 2003, The international journal of biochemistry & cell biology.

[178]  J. Culberson,et al.  An integrative review on current evidence of testosterone replacement therapy for the andropause. , 2003, Maturitas.

[179]  B. Zhao,et al.  ELITE CHINESE POWER ATHLETES AND CNTF (CILIARY NEUROTROPHIC FACTOR) GENETIC POLYMORPHISM , 2003 .

[180]  S. Andrieu,et al.  Body composition in French women 75+ years of age: The EPIDOS study , 2003, Mechanisms of Ageing and Development.

[181]  Denise M O'Hara,et al.  Inhibition of myostatin in adult mice increases skeletal muscle mass and strength. , 2003, Biochemical and biophysical research communications.

[182]  遠藤 逸朗.  Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors , 2003 .

[183]  E. Metter,et al.  C 174 T polymorphism in the CNTF receptor gene is associated with fat-free mass in men and women , 2003 .

[184]  Pak Chung Sham,et al.  Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits , 2003, Bioinform..

[185]  A. Kenny,et al.  Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[186]  C. Cooper,et al.  Polymorphism of the IGF2 gene, birth weight and grip strength in adult men. , 2002, Age and ageing.

[187]  E. Metter,et al.  Influence of age, sex, and strength training on human muscle gene expression determined by microarray. , 2002, Physiological genomics.

[188]  J. Vaupel,et al.  Hand grip strength: A phenotype suitable for identifying genetic variants affecting mid‐ and late‐life physical functioning , 2002, Genetic epidemiology.

[189]  L. Ferrucci,et al.  Myostatin Polymorphisms and Age‐Related Sarcopenia in the Italian Population , 2002, Journal of the American Geriatrics Society.

[190]  S. Mohan,et al.  Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F2 mice , 2002, Functional & Integrative Genomics.

[191]  T. Tuschl,et al.  Identification of Tissue-Specific MicroRNAs from Mouse , 2002, Current Biology.

[192]  J. Partanen,et al.  Relation of estrogen receptor-α gene polymorphism and hormone replacement therapy to fall risk and muscle strength in early postmenopausal women , 2002, Annals of medicine.

[193]  S. Mohan,et al.  Quantitative trait loci that harbor genes regulating muscle size in (MRL/MPJ x SJL/J) F(2) mice. , 2002, Functional & integrative genomics.

[194]  C. Emerson,et al.  Myogenic regulatory factors and the specification of muscle progenitors in vertebrate embryos. , 2002, Annual review of cell and developmental biology.

[195]  A. von Eckardstein,et al.  The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men , 2002, Diabetologia.

[196]  R. Recker,et al.  Characterization of genetic and lifestyle factors for determining variation in body mass index, fat mass, percentage of fat mass, and lean mass. , 2001, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[197]  L. Fried,et al.  Polymorphic Variation in the Human Myostatin (GDF‐8) Gene and Association with Strength Measures in the Women's Health and Aging Study II Cohort , 2001, Journal of the American Geriatrics Society.

[198]  Y. Chagnon,et al.  Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE. , 2001, Journal of applied physiology.

[199]  M. McPeek,et al.  Broad and narrow heritabilities of quantitative traits in a founder population. , 2001, American journal of human genetics.

[200]  D B Allison,et al.  Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[201]  R. Tibshirani,et al.  Significance analysis of microarrays applied to the ionizing radiation response , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[202]  E. Metter,et al.  CNTF genotype is associated with muscular strength and quality in humans across the adult age span. , 2001, Journal of applied physiology.

[203]  T. B. Symons,et al.  Functional and metabolic consequences of sarcopenia. , 2001, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[204]  P. Geusens,et al.  Type I alfa 1 collagen gene polymorphism is associated with bone density, muscle strength and susceptibility for fractures in elderly women. , 2001 .

[205]  S. Humphries,et al.  Angiotensin-I converting enzyme genotype-dependent benefit from hormone replacement therapy in isometric muscle strength and bone mineral density. , 2001, The Journal of clinical endocrinology and metabolism.

[206]  J. Kaufman,et al.  Association of the Type I Collagen alpha1 Sp1 Polymorphism, Bone Density and Upper Limb Muscle Strength in Community-Dwelling Elderly Men , 2001, Osteoporosis International.

[207]  S. Gordon,et al.  ANG II is required for optimal overload-induced skeletal muscle hypertrophy. , 2001, American journal of physiology. Endocrinology and metabolism.

[208]  W. Evans,et al.  Aged human muscle demonstrates an altered gene expression profile consistent with an impaired response to exercise , 2000, Mechanisms of Ageing and Development.

[209]  B. Reinhart,et al.  Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA , 2000, Nature.

[210]  D. Carmelli,et al.  Stability and change in genetic and environmental influences on hand-grip strength in older male twins. , 2000, Journal of applied physiology.

[211]  David A Jones,et al.  Angiotensin‐Converting Enzyme Genotype Affects the Response of Human Skeletal Muscle to Functional Overload , 2000, Experimental physiology.

[212]  E. Olson,et al.  Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. , 2000, Molecular cell.

[213]  P. Esselman,et al.  Oxidative capacity and ageing in human muscle , 2000, The Journal of physiology.

[214]  S. Welle,et al.  High-abundance mRNAs in human muscle: comparison between young and old. , 2000, Journal of applied physiology.

[215]  W. O'Fallon,et al.  Epidemiology of Sarcopenia , 2000, Journal of the American Geriatrics Society.

[216]  R. Roubenoff,et al.  Sarcopenic Obesity: Does Muscle Loss Cause Fat Gain?: Lessons from Rheumatoid Arthritis and Osteoarthritis a , 2000 .

[217]  Y. Chagnon,et al.  Genome-wide search for genes related to the fat-free body mass in the Québec family study. , 2000, Metabolism: clinical and experimental.

[218]  M. Rudnicki,et al.  The molecular regulation of myogenesis , 2000, Clinical genetics.

[219]  L. Melton,et al.  Epidemiology of sarcopenia. , 2000, Journal of the American Geriatrics Society.

[220]  R. Ferrell,et al.  Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes. , 1999, Genomics.

[221]  E. Olson,et al.  MEF2: a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation. , 1999, Current opinion in cell biology.

[222]  Y. Chagnon,et al.  Association and linkage between an insulin-like growth FACTOR-1 GENE polymorphism and fat free mass in the HERITAGE Family Study , 1999, International Journal of Obesity.

[223]  C. K. Lee,et al.  Gene expression profile of aging and its retardation by caloric restriction. , 1999, Science.

[224]  S. Easteal,et al.  A common nonsense mutation results in α-actinin-3 deficiency in the general population , 1999, Nature Genetics.

[225]  R. Baumgartner,et al.  Predictors of skeletal muscle mass in elderly men and women , 1999, Mechanisms of Ageing and Development.

[226]  R. Leibel,et al.  Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Québec Family Study , 1999, International Journal of Obesity.

[227]  S. Easteal,et al.  A common nonsense mutation results in alpha-actinin-3 deficiency in the general population. , 1999, Nature genetics.

[228]  A. Claessens,et al.  Inheritance of static and dynamic arm strength and some of its determinants. , 1998, Acta physiologica Scandinavica.

[229]  S. Heymsfield,et al.  Epidemiology of sarcopenia among the elderly in New Mexico. , 1998, American journal of epidemiology.

[230]  I. Borecki,et al.  Evidence for multiple determinants of the body mass index: the National Heart, Lung, and Blood Institute Family Heart Study. , 1998, Obesity research.

[231]  H. Degens.  Age-related changes in the microcirculation of skeletal muscle. , 1998, Advances in experimental medicine and biology.

[232]  P. Geusens,et al.  Quadriceps and Grip Strength Are Related to Vitamin D Receptor Genotype in Elderly Nonobese Women , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[233]  T. Spector,et al.  Genetic Influences on Muscle Strength, Lean Body Mass, and Bone Mineral Density: A Twin Study , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[234]  T. Ikeda,et al.  Role of bradykinin-NO pathway in prevention of cardiac hypertrophy by ACE inhibitor in rat cardiomyocytes. , 1997, American journal of physiology. Heart and circulatory physiology.

[235]  S. Heymsfield,et al.  Standardization of nomenclature of body composition in weight loss. , 1997, The American journal of clinical nutrition.

[236]  Se-Jin Lee,et al.  Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member , 1997, nature.

[237]  L. Tiret,et al.  Segregation analysis of fat mass and fat‐free mass with age‐ and sex‐dependent effects: The Stanislas family study , 1997, Genetic epidemiology.

[238]  K. Davies,et al.  Amelioration of the dystrophic phenotype of mdx mice using a truncated utrophin transgene , 1996, Nature.

[239]  Nair Ks.  Muscle Protein Turnover: Methodological Issues and the Effect of Aging , 1995 .

[240]  S. Roberts,et al.  Effects of aging on energy requirements and the control of food intake in men. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[241]  H. Schunkert,et al.  Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. , 1995, Circulation.

[242]  K. Nair.  Muscle protein turnover: methodological issues and the effect of aging. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[243]  L. Larsson,et al.  Effects of thyroid hormone on fast‐ and slow‐twitch skeletal muscles in young and old rats. , 1994, The Journal of physiology.

[244]  P. Caroni,et al.  Role of muscle insulin-like growth factors in nerve sprouting: suppression of terminal sprouting in paralyzed muscle by IGF-binding protein 4 , 1994, The Journal of cell biology.

[245]  C. Bouchard,et al.  Segregation analysis of fat mass and other body composition measures derived from underwater weighing. , 1993, American journal of human genetics.

[246]  M. Bárány,et al.  ATPase Activity of Myosin Correlated with Speed of Muscle Shortening , 1967, The Journal of general physiology.

[247]  R. Ch.,et al.  NUTRITION IN GERIATRICS. , 1963 .