NEUROMUSCULAR BLOCKING AGENTS

NSN‐ and NNN‐Tris‐onium compounds related to dihexasulphonium and dihexazonium in which N‐alkyl substituents are varied have been synthesised. All compounds tested qualitatively resembled tubocurarine in their action. Stepwise replacement of Et by Me in dihexasulphonium tri‐ethiodide decreases potency and some C 10‐like effects appear in compounds Xa and Xb. Potency also falls when Et groups are replaced successively by n‐Pr in both dihexasulphonium tri‐ethiodide and dihexazonium tri‐ethiodide, compounds XIf and XIg being the least active of the series and approximately equipotent with dihexasulphonium trimethiodide (Xa). Replacement of one Et group by n‐Bu at each quaternary ammonium centre of dihexazonium, as in compound XIc increases potency.

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