Diffuse Panbronchiolitis

Diffuse panbronchiolitis (DPB) is an idiopathic inflammatory disease, well recognised in Japan and principally affecting the respiratory bronchioles, causing a progressive suppurative and severe obstructive respiratory disorder. If left untreated, DPB progresses to bronchiectasis, respiratory failure and death. It was first described in the early 1960s. Subsequently, in 1969, the disease was named DPB to distinguish it from chronic bronchitis. ‘‘Diffuse’’ refers to the distribution of the lesions throughout both lungs, and ‘‘pan-’’ refers to the involvement of inflammation in all layers of the respiratory

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