Early life linguistic ability, late life cognitive function, and neuropathology: findings from the Nun Study

The relationships between early life variables, cognitive function, and neuropathology were examined in participants in the Nun Study who were between the ages of 75 and 95. Our early life variable was idea density, which is a measure of linguistic ability, derived from autobiographies written at a mean age of 22 years. Six discrete categories of cognitive function, including mild cognitive impairments, were evaluated, using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) battery of cognitive tests. Neuropathologic data included Braak staging, neurofibrillary tangle and senile plaque counts, brain weight, degree of cerebral atrophy, severity of atherosclerosis, and the presence of brain infarcts. Early-life idea density was significantly related to the categories of late-life cognitive function, including mild cognitive impairments: low idea density was associated with greater impairment. Low idea density also was significantly associated with lower brain weight, higher degree of cerebral atrophy, more severe neurofibrillary pathology, and the likelihood of meeting neuropathologic criteria for Alzheimer's disease.

[1]  H. Braak,et al.  Neuropathological stageing of Alzheimer-related changes , 2004, Acta Neuropathologica.

[2]  H. Braak,et al.  Close-meshed prevalence rates of different stages as a tool to uncover the rate of Alzheimer's disease-related neurofibrillary changes , 1995, Neuroscience.

[3]  H. Massie,et al.  Linguistic ability in early life and Alzheimer disease in late life. , 1996, JAMA.

[4]  Claudio Franceschi,et al.  The Paradoxes of Longevity , 1999, Research and Perspectives in Longevity.

[5]  Arthur L. Benton,et al.  Word fluency and brain damage , 1967 .

[6]  R. Mohs,et al.  Consortium to establish a registry for Alzheimer's disease (CERAD) clinical and neuropsychological assessment of Alzheimer's disease. , 2002, Psychopharmacology bulletin.

[7]  M. Laakso,et al.  A Follow‐Up Study of Age‐Associated Memory Impairment: Neuropsychological Predictors of Dementia , 1995, Journal of the American Geriatrics Society.

[8]  R. Petersen,et al.  Mild cognitive impairment: transition between aging and Alzheimer's disease. , 2000, Neurologia.

[9]  R W Pew,et al.  Simulated activities of daily living examination. , 1972, Archives of physical medicine and rehabilitation.

[10]  James A. Mortimer,et al.  Linguistic Ability in Early Life and Longevity: Findings from the Nun Study , 1999 .

[11]  N. Butters,et al.  The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsychological battery , 1994, Neurology.

[12]  A. Roses,et al.  Cognitive function and apolipoprotein E in very old adults: findings from the Nun Study. , 2000, The journals of gerontology. Series B, Psychological sciences and social sciences.

[13]  D. Snowdon,et al.  Aging and Alzheimer's disease: lessons from the Nun Study. , 1997, The Gerontologist.

[14]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[15]  E. Kaplan,et al.  The Boston naming test , 2001 .

[16]  Walter Kintsch,et al.  Reading rate and retention as a function of the number of propositions in the base structure of sentences , 1973 .

[17]  W R Markesbery,et al.  Linguistic Ability in Early Life and the Neuropathology of Alzheimer's Disease and Cerebrovascular Disease: Findings from the Nun Study , 2000, Annals of the New York Academy of Sciences.

[18]  W. Friesen,et al.  PERSONALITY PROCESSES AND INDIVIDUAL DIFFERENCES Positive Emotions in Early Life and Longevity : Findings from the Nun Study , 2004 .

[19]  D. Snowdon,et al.  Trends in mortality in older women: findings from the Nun Study. , 1996, The journals of gerontology. Series B, Psychological sciences and social sciences.

[20]  M. Pericak-Vance,et al.  Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease , 1996, The Lancet.

[21]  J. Touchon,et al.  Cognitive decline in ageing: are AAMI and AACD distinct entities? , 1999, International journal of geriatric psychiatry.

[22]  B. Gurland,et al.  The performance test of activities of daily living. , 1976, International journal of aging & human development.

[23]  C. Gillberg,et al.  Looking Backward to Move Forward: Early Detection of Neurodegenerative Disorders , 2003 .

[24]  J. Morris,et al.  The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's disease , 1989, Neurology.

[25]  J. Morris,et al.  Current concepts in mild cognitive impairment. , 2001, Archives of neurology.

[26]  R. Petersen.  Mild cognitive impairment or questionable dementia? , 2000, Archives of neurology.

[27]  K. Davis,et al.  A new rating scale for Alzheimer's disease. , 1984, The American journal of psychiatry.

[28]  W. Markesbery,et al.  Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study. , 2000, The American journal of clinical nutrition.

[29]  W. Markesbery,et al.  Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: Findings from the Nun Study , 2002, Annals of neurology.

[30]  David Snowdon,et al.  Aging with Grace: What the Nun Study Teaches Us About Leading Longer, Healthier, and More Meaningful Lives , 2001 .

[31]  J. Ashford,et al.  Comparison of Neuropathologic Criteria for the Diagnosis of Alzheimer’s Disease , 1997, Neurobiology of Aging.

[32]  J. Touchon,et al.  Mild cognitive impairment: conceptual basis and current nosological status , 2000, The Lancet.

[33]  W. Markesbery,et al.  Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. , 1997, JAMA.

[34]  P. Celsis,et al.  Age-related cognitive decline, mild cognitive impairment or preclinical Alzheimer's disease? , 2000, Annals of medicine.