Safety and Biodistribution of Human Bone Marrow-Derived Mesenchymal Stromal Cells Injected Intrathecally in Non-Obese Diabetic Severe Combined Immunodeficiency Mice: Preclinical Study

[1]  B. Green,et al.  Clinical and Neurophysiological Changes after Targeted Intrathecal Injections of Bone Marrow Stem Cells in a C3 Tetraplegic Subject. , 2019, Journal of neurotrauma.

[2]  J. Carballido,et al.  Intrathecal administration of autologous mesenchymal stromal cells for spinal cord injury: Safety and efficacy of the 100/3 guideline. , 2018, Cytotherapy.

[3]  S. Sadiq,et al.  Phase I Trial of Intrathecal Mesenchymal Stem Cell-derived Neural Progenitors in Progressive Multiple Sclerosis , 2018, EBioMedicine.

[4]  L. Corben,et al.  Cerebral abnormalities in Friedreich ataxia: A review , 2018, Neuroscience & Biobehavioral Reviews.

[5]  A. Koeppen,et al.  Somatic instability of the expanded GAA repeats in Friedreich’s ataxia , 2017, PloS one.

[6]  C. Heyser,et al.  Transplantation of wild-type mouse hematopoietic stem and progenitor cells ameliorates deficits in a mouse model of Friedreich’s ataxia , 2017, Science Translational Medicine.

[7]  S. Lope-Piedrafita,et al.  Assessment of biodistribution using mesenchymal stromal cells: Algorithm for study design and challenges in detection methodologies. , 2017, Cytotherapy.

[8]  I. Vorisek,et al.  Transplantation of Mesenchymal Stromal Cells in Patients with Amyotrophic Lateral Sclerosis: Results of Phase I/IIa Clinical Trial , 2017, Cell transplantation.

[9]  L. Howard,et al.  Biodistribution and retention of locally administered human mesenchymal stromal cells: Quantitative polymerase chain reaction-based detection of human DNA in murine organs. , 2017, Cytotherapy.

[10]  S. Sadiq,et al.  Clinical safety of intrathecal administration of mesenchymal stromal cell-derived neural progenitors in multiple sclerosis. , 2016, Cytotherapy.

[11]  A. Inuggi,et al.  Spinal cord infusion of stem cells in amyotrophic lateral sclerosis: Magnetic resonance spectroscopy shows metabolite improvement in the precentral gyrus. , 2016, Cytotherapy.

[12]  J. Yun,et al.  Preclinical Biosafety Evaluation of Genetically Modified Human Adipose Tissue-Derived Mesenchymal Stem Cells for Clinical Applications to Brainstem Glioma. , 2016, Stem cells and development.

[13]  A. Koeppen,et al.  Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation , 2016, Acta Neuropathologica Communications.

[14]  M. Blanquer,et al.  Autologous bone marrow mononuclear cells as neuroprotective treatment of amyotrophic lateral sclerosis , 2016, Neural regeneration research.

[15]  M. Noda,et al.  Role of pleiotrophin-protein tyrosine phosphatase receptor type Z signaling in myelination , 2016, Neural regeneration research.

[16]  E. Melamed,et al.  Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis: Results of Phase 1/2 and 2a Clinical Trials. , 2016, JAMA neurology.

[17]  R. Henschler,et al.  Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells , 2016, Stem Cell Research & Therapy.

[18]  S. Tezenas du Montcel,et al.  A 22-Year Follow-up Study of Long-term Cardiac Outcome and Predictors of Survival in Friedreich Ataxia. , 2015, JAMA neurology.

[19]  J. Moraleda,et al.  Novel aberrant genetic and epigenetic events in Friedreich's ataxia. , 2015, Experimental cell research.

[20]  Hyun Young Kim,et al.  Phase I Trial of Repeated Intrathecal Autologous Bone Marrow‐Derived Mesenchymal Stromal Cells in Amyotrophic Lateral Sclerosis , 2015, Stem cells translational medicine.

[21]  Imran Ullah,et al.  Human mesenchymal stem cells - current trends and future prospective , 2015, Bioscience reports.

[22]  P. Svítil,et al.  Intrathecal Delivery of Mesenchymal Stromal Cells Protects the Structure of Altered Perineuronal Nets in SOD1 Rats and Amends the Course of ALS , 2014, Stem cells.

[23]  Wei Cao,et al.  Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications , 2014, Nature Immunology.

[24]  M. Benderitter,et al.  Long-Term Quantitative Biodistribution and Side Effects of Human Mesenchymal Stem Cells (hMSCs) Engraftment in NOD/SCID Mice following Irradiation , 2014, Stem cells international.

[25]  R. Tabarés-Seisdedos,et al.  Human Adult Periodontal Ligament-Derived Cells Integrate and Differentiate after Implantation into the Adult Mammalian Brain , 2013, Cell transplantation.

[26]  C. Jorgensen,et al.  Long-term detection of human adipose-derived mesenchymal stem cells after intraarticular injection in SCID mice. , 2013, Arthritis and rheumatism.

[27]  S. Martinez,et al.  Stem Cells from Wildtype and Friedreich’s Ataxia Mice Present Similar Neuroprotective Properties in Dorsal Root Ganglia Cells , 2013, PloS one.

[28]  J. Moraleda,et al.  Bone marrow transplantation in hindlimb muscles of motoneuron degenerative mice reduces neuronal death and improves motor function. , 2013, Stem cells and development.

[29]  J. Marshall,et al.  Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials , 2012, PloS one.

[30]  L. Corben,et al.  Clinical Features of Friedreich Ataxia , 2012, Journal of child neurology.

[31]  C. Antunez,et al.  Neurotrophic Bone Marrow Cellular Nests Prevent Spinal Motoneuron Degeneration in Amyotrophic Lateral Sclerosis Patients: A Pilot Safety Study , 2012, Stem cells.

[32]  J. Moraleda,et al.  Comparative Effects between Bone Marrow and Mesenchymal Stem Cell Transplantation in GDNF Expression and Motor Function Recovery in a Motorneuron Degenerative Mouse Model , 2012, Stem Cell Reviews and Reports.

[33]  S. Martinez,et al.  Human adipose stem cell-conditioned medium increases survival of Friedreich's ataxia cells submitted to oxidative stress. , 2012, Stem cells and development.

[34]  E. Mallam,et al.  Mesenchymal Stem Cells Restore Frataxin Expression and Increase Hydrogen Peroxide Scavenging Enzymes in Friedreich Ataxia Fibroblasts , 2011, PloS one.

[35]  E. Syková,et al.  Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis. , 2011, Cytotherapy.

[36]  J. Moraleda,et al.  Mesenchymal stem cells derived from dental tissues. , 2011, International endodontic journal.

[37]  D. Marmolino Friedreich's ataxia: Past, present and future , 2011, Brain Research Reviews.

[38]  A. Koeppen Friedreich's ataxia: Pathology, pathogenesis, and molecular genetics , 2011, Journal of the Neurological Sciences.

[39]  J. Nolta,et al.  Mesenchymal stem cells for the treatment of neurodegenerative disease. , 2010, Regenerative medicine.

[40]  J. Jaramillo-Merchán,et al.  Mesenchymal stem cells rescue Purkinje cells and improve motor functions in a mouse model of cerebellar ataxia , 2010, Neurobiology of Disease.

[41]  J. Bulte,et al.  Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. , 2010, Archives of neurology.

[42]  M. Bühler,et al.  Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation , 2010, EMBO molecular medicine.

[43]  H. Yoon,et al.  Dose-dependent efficacy of ALS-human mesenchymal stem cells transplantation into cisterna magna in SOD1-G93A ALS mice , 2010, Neuroscience Letters.

[44]  J. Schulz,et al.  Diagnosis and treatment of Friedreich ataxia: a European perspective , 2009, Nature Reviews Neurology.

[45]  S. Martinez,et al.  Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration , 2007, Neurobiology of Disease.

[46]  J. Moraleda,et al.  Adult stem cell therapy: dream or reality? , 2006, Transplant immunology.

[47]  J. García-Verdugo,et al.  Functional neural stem cells derived from adult bone marrow , 2005, Neuroscience.

[48]  L. Mazzini,et al.  Stem cell therapy in amyotrophic lateral sclerosis: a methodological approach in humans , 2003, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases.

[49]  P. Patel,et al.  Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion , 1996, Science.

[50]  J. García-Verdugo,et al.  Mesenchymal stem cells improve motor functions and decrease neurodegeneration in ataxic mice. , 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

[51]  D. Prockop,et al.  Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. , 2006, Cytotherapy.

[52]  D. Phinney,et al.  Quantifying levels of transplanted murine and human mesenchymal stem cells in vivo by real-time PCR. , 2003, Cytotherapy.