Neuroprotective approaches in experimental models of β-Amyloid neurotoxicity: Relevance to Alzheimer's disease

[1]  S. Heck,et al.  Reactive oxygen species in Alzheimer's disease , 1999, European Neuropsychopharmacology.

[2]  T. Harkany,et al.  Propionyl-IIGL tetrapeptide antagonizes beta-amyloid excitotoxicity in rat nucleus basalis. , 1999, Neuroreport.

[3]  J. Korf,et al.  Neuroprotection against N-methyl-D-aspartate-induced excitotoxicity in rat magnocellular nucleus basalis by the 5-HT1A receptor agonist 8-OH-DPAT. , 1998, European journal of pharmacology.

[4]  B. Penke,et al.  β-Amyloid (1–42) peptide impairs blood-brain barrier function after intracarotid infusion in rats , 1998, Neuroscience Letters.

[5]  B. Zlokovic,et al.  Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. , 1998, The Journal of clinical investigation.

[6]  P. Mcgeer,et al.  The importance of inflammatory mechanisms in alzheimer disease , 1998, Experimental Gerontology.

[7]  G. Taglialatela,et al.  Ascorbic acid prevents β-amyloid-induced intracellular calcium increase and cell death in PC12 cells , 1998, Neuroscience Letters.

[8]  L. Giovannelli,et al.  Long-term changes in the aggregation state and toxic effects of β-amyloid injected into the rat brain , 1998, Neuroscience.

[9]  Bruce A. Yankner,et al.  Aging renders the brain vulnerable to amyloid β-protein neurotoxicity , 1998, Nature Medicine.

[10]  D. Riesner,et al.  Detection of single amyloid β-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy , 1998, Nature Medicine.

[11]  Claudio Soto,et al.  β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy , 1998, Nature Medicine.

[12]  T. Hasegawa,et al.  Continuous infusion of beta-amyloid protein into the rat cerebral ventricle induces learning impairment and neuronal and morphological degeneration. , 1998, Japanese journal of pharmacology.

[13]  T. Morgan,et al.  Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Xudong Huang,et al.  Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis* , 1998, The Journal of Biological Chemistry.

[15]  T. Kameyama,et al.  Propentofylline improves learning and memory deficits in rats induced by beta-amyloid protein-(1-40). , 1998, European journal of pharmacology.

[16]  C. Albanese,et al.  Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism , 1998 .

[17]  O. Jørgensen,et al.  Amyloid beta-peptide(25-35) changes [Ca2+] in hippocampal neurons. , 1998, Neuroreport.

[18]  F. Holsboer,et al.  High Constitutive NFk B Activity Mediates Resistance to Oxidative Stress in Neuronal Cells , 1998 .

[19]  P. Greengard,et al.  Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides , 1998, Nature Medicine.

[20]  D. Butterfield,et al.  Vitamin E protects against Alzheimer's amyloid peptide (25–35)-induced changes in neocortical synaptosomal membrane lipid structure and composition , 1998, Brain Research.

[21]  T. Harkany,et al.  β-Amyloid-Induced Cholinergic Denervation Correlates with Enhanced Nitric Oxide Synthase Activity in Rat Cerebral Cortex: Reversal by NMDA Receptor Blockade , 1998, Brain Research Bulletin.

[22]  G. Reiser,et al.  β-Amyloid peptide 25–35 regulates basal and hormone-stimulated Ca2+ levels in cultured rat astrocytes , 1998, Neuroscience Letters.

[23]  K. Yoshimi,et al.  Co-injection of β-amyloid with ibotenic acid induces synergistic loss of rat hippocampal neurons , 1998, Neuroscience.

[24]  T. Harkany,et al.  induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation , 1998 .

[25]  M. Mattson.  Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity , 1998, Trends in Neurosciences.

[26]  N. Takahata,et al.  Calcium mobilization evoked by amyloid beta-protein involves inositol 1,4,5-triphosphate production in human platelets. , 1998, Life sciences.

[27]  S. Kohsaka,et al.  Involvement of amyloid precursor protein in functional synapse formation in cultured hippocampal neurons , 1998, Journal of neuroscience research.

[28]  W. Griffin,et al.  Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression , 1998, Brain pathology.

[29]  J. Bading,et al.  Cerebrovascular Accumulation and Increased Blood‐Brain Barrier Permeability to Circulating Alzheimer's Amyloid β Peptide in Aged Squirrel Monkey with Cerebral Amyloid Angiopathy , 1998, Journal of neurochemistry.

[30]  R. Quirion,et al.  β-Amyloid peptides as direct cholinergic neuromodulators: a missing link? , 1998, Trends in Neurosciences.

[31]  G. Lees,et al.  Zinc Metabolism in the Brain: Relevance to Human Neurodegenerative Disorders , 1997, Neurobiology of Disease.

[32]  J. Simpkins,et al.  Low concentrations of estradiol reduce β-amyloid (25–35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells , 1997, Brain Research.

[33]  C. Behl.  Amyloid β-protein toxicity and oxidative stress in Alzheimer’s disease , 1997, Cell and Tissue Research.

[34]  M. Mattson,et al.  17β‐Estradiol attenuates oxidative impairment of synaptic Na+/K+‐ATPase activity, glucose transport, and glutamate transport induced by amyloid β‐peptide and iron , 1997, Journal of neuroscience research.

[35]  G. Forloni,et al.  Amidation of β‐Amyloid Peptide Strongly Reduced the Amyloidogenic Activity Without Alteration of the Neurotoxicity , 1997, Journal of neurochemistry.

[36]  J. Trojanowski,et al.  Amyloid β-Protein (Aβ) 1–40 But Not Aβ1–42 Contributes to the Experimental Formation of Alzheimer Disease Amyloid Fibrils in Rat Brain , 1997, The Journal of Neuroscience.

[37]  Xudong Huang,et al.  Zinc-induced Alzheimer’s Aβ1–40 Aggregation Is Mediated by Conformational Factors* , 1997, The Journal of Biological Chemistry.

[38]  I. Mook‐Jung,et al.  Estrogen blocks neurotoxic effects of β-amyloid (1–42) and induces neurite extension on B103 cells , 1997, Neuroscience Letters.

[39]  E. Gwebu,et al.  Cytotoxicity of β-amyloid peptide 25–35 on vascular smooth muscle cells and attenuation by vitamin E , 1997, In Vitro Cellular & Developmental Biology - Animal.

[40]  C. Cotman,et al.  β‐Amyloid Neurotoxicity In Vitro: Evidence of Oxidative Stress but Not Protection by Antioxidants , 1997, Journal of neurochemistry.

[41]  S. Prabhakar,et al.  β‐amyloid and ionophore A23187 evoke tau hyperphosphorylation by distinct intracellular pathways: Differential involvement of the calpain/protein kinase C system , 1997, Journal of neuroscience research.

[42]  T. Harkany,et al.  Effect of Corticosterone and Adrenalectomy on NMDA‐Induced Cholinergic Cell Death in Rat Magnocellular Nucleus Basalis , 1997, Journal of neuroendocrinology.

[43]  C. Masters,et al.  Reactive oxygen species and Alzheimer's disease. , 1997, Biochemical pharmacology.

[44]  W. Banks,et al.  Interactions of β‐Amyloids with the Blood–Brain Barrier , 1997, Annals of the New York Academy of Sciences.

[45]  M. Mullan,et al.  Superoxide free radical and intracellular calcium mediate Aβ 1–42 induced endothelial toxicity , 1997, Brain Research.

[46]  M. Kawahara,et al.  Alzheimer's disease amyloid beta-protein forms Zn(2+)-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons. , 1997, Biophysical journal.

[47]  H. Braak,et al.  Diagnostic Criteria for Neuropathologic Assessment of Alzheimer’s Disease , 1997, Neurobiology of Aging.

[48]  B. Penke,et al.  A putative tetrapeptide antagonist prevents beta-amyloid-induced long-term elevation of [Ca2+]i in rat astrocytes. , 1997, Biochemical and biophysical research communications.

[49]  C. Kaltschmidt,et al.  NF-kB: a crucial transcription factor for glial and neuronal cell function , 1997, Trends in Neurosciences.

[50]  M. Mattson,et al.  Basic FGF attenuates amyloid β-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons , 1997, Brain Research.

[51]  B. Solomon,et al.  Disaggregation of Alzheimer β-amyloid by site-directed mAb , 1997 .

[52]  V. Bohr,et al.  Aging processes, DNA damage, and repair 1 , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[53]  F. Holsboer,et al.  Neuroprotection against oxidative stress by estrogens: structure-activity relationship. , 1997, Molecular pharmacology.

[54]  P. Baeuerle,et al.  Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease , 1997 .

[55]  M. Joëls.  Steroid Hormones and Excitability in the Mammalian Brain , 1997, Frontiers in Neuroendocrinology.

[56]  A. Privat,et al.  In vitro aggregation facilitates β-amyloid peptide-(25–35)-induced amnesia in the rat , 1997 .

[57]  M. Mattson,et al.  A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide , 1997, Journal of neurochemistry.

[58]  K. Kawasaki,et al.  Amyloid β Protein Potentiates Ca2+ Influx Through L‐Type Voltage‐Sensitive Ca2+ Channels: A Possible Involvement of Free Radicals , 1997, Journal of neurochemistry.

[59]  R. Beavis,et al.  The length of Amyloid-β in Hereditary Cerebral Hemorrhage with Amyloidosis, Dutch Type , 1996, The Journal of Biological Chemistry.

[60]  H. Budka,et al.  Familial meningocerebrovascular amyloidosis, Hungarian type, with mutant transthyretin (TTR Asp18Gly) , 1996, Neurology.

[61]  L. Kiessling,et al.  A Strategy for Designing Inhibitors of β-Amyloid Toxicity* , 1996, The Journal of Biological Chemistry.

[62]  J. Simpkins,et al.  Estradiol protects against β-amyloid (25–35)-induced toxicity in SK-N-SH human neuroblastoma cells , 1996, Neuroscience Letters.

[63]  J. Korf,et al.  Clinical Pharmacology of Cerebral Ischemia , 1996, Contemporary Neuroscience.

[64]  V. Henderson,et al.  Estrogen replacement therapy and risk of Alzheimer disease. , 1996, Archives of internal medicine.

[65]  D. Newell,et al.  Combination Therapy with MK-801 and α-Phenyl-tert-butyl-nitrone Enhances Protection against Ischemic Neuronal Damage in Organotypic Hippocampal Slice Cultures , 1996, Experimental Neurology.

[66]  A. Privat,et al.  Reversion of β25–35-amyloid peptide-induced amnesia by NMDA receptor-associated glycine site agonists , 1996, Brain Research.

[67]  X. Chen,et al.  RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease , 1996, Nature.

[68]  D. Butterfield,et al.  Amyloid β Peptide (25–35) Inhibits Na+‐Dependent Glutamate Uptake in Rat Hippocampal Astrocyte Cultures , 1996, Journal of neurochemistry.

[69]  G. Forloni,et al.  Amyloid in alzheimer's disease and prion-related encephalopathies: Studies with synthetic peptides , 1996, Progress in Neurobiology.

[70]  C. Nyakas,et al.  In vivo protection against NMDA-induced neurodegeneration by MK-801 and nimodipine: combined therapy and temporal course of protection. , 1996, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

[71]  M. Mattson,et al.  Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons , 1996, Journal of neurochemistry.

[72]  L. Tjernberg,et al.  Arrest of -Amyloid Fibril Formation by a Pentapeptide Ligand (*) , 1996, The Journal of Biological Chemistry.

[73]  S. Asano,et al.  Inhibition of Amyloid Protein Aggregation and Neurotoxicity by Rifampicin , 1996, The Journal of Biological Chemistry.

[74]  T. Hasegawa,et al.  Dysfunction of Cholinergic and Dopaminergic Neuronal Systems in β‐Amyloid Protein‐Infused Rats , 1996, Journal of neurochemistry.

[75]  M. Hurle,et al.  Selective Inhibition of A Fibril Formation , 1996, The Journal of Biological Chemistry.

[76]  E. Rojas,et al.  Zn2+ interaction with Alzheimer amyloid beta protein calcium channels. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[77]  H. Budka,et al.  Meningocerebrovascular amyloidosis associated with a novel transthyretin mis-sense mutation at codon 18 (TTRD 18G) , 1996, The American journal of pathology.

[78]  M. Mattson,et al.  K+ channel openers protect hippocampal neurons against oxidative injury and amyloid β-peptide toxicity , 1996, Brain Research.

[79]  T. Nabeshima,et al.  Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1–40) protein , 1995, Neuroscience Letters.

[80]  T. Harkany,et al.  β-Amyloid(1–42) affects cholinergic but not parvalbumin-containing neurons in the septal complex of the rat , 1995, Brain Research.

[81]  W. Pardridge,et al.  Vector-mediated delivery of 125I-labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer disease amyloid of the A beta 1-40/vector complex. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[82]  T. Harkany,et al.  Cholinotoxic effects of β-amyloid(1–42) peptide on cortical projections of the rat nucleus basalis magnocellularis , 1995, Brain Research.

[83]  M. Mattson,et al.  Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca2+ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons , 1995, Journal of neurochemistry.

[84]  F. Checler.  Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's Disease , 1995 .

[85]  M. Mattson,et al.  Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[86]  S. Pietri,et al.  Calcium-dependent free radical generation in cultured retinal neurons injured by kainate , 1995, Neuroscience Letters.

[87]  C. Gray,et al.  Neurodegeneration mediated by glutamate and β-amyloid peptide: a comparison and possible interaction , 1995, Brain Research.

[88]  C. Nyakas,et al.  Neuroprotection against NMDA induced cell death in rat nucleus basalis by Ca2+ antagonist nimodipine, influence of aging and developmental drug treatment. , 1995, Neurodegeneration.

[89]  B. Frangione,et al.  Non-Alzheimer's disease amyloidoses of the nervous system. , 1995, Current opinion in neurology.

[90]  M. Mattson.  Free radicals and disruption of neuronal ion homeostasis in AD: A role for amyloid β-peptide? , 1995, Neurobiology of Aging.

[91]  L. Giovannelli,et al.  Differential effects of amyloid peptides β-(1–40) and β-(25–35) injections into the rat nucleus basalis , 1995, Neuroscience.

[92]  R. Cowburn,et al.  β-amyloid peptides enhance binding of the calcium mobilising second messengers, inositol(1,4,5)trisphosphate and inositol-(1,3,4,5)tetrakisphosphate to their receptor sites in rat cortical membranes , 1995, Neuroscience Letters.

[93]  Mark A. Smith,et al.  Radical AGEing in Alzheimer's disease , 1995, Trends in Neurosciences.

[94]  J. Rogers.  Inflammation as a pathogenic mechanism in Alzheimer's disease. , 1995, Arzneimittel-Forschung.

[95]  P Riederer,et al.  Free radical mechanisms in dementia of Alzheimer type and the potential for antioxidative treatment. , 1995, Arzneimittel-Forschung.

[96]  M. Mattson,et al.  Anticonvulsants attenuate amyloid β-peptide neurotoxicity, Ca2+ deregulation, and cytoskeletal pathology , 1995, Neurobiology of Aging.

[97]  J. Whitson,et al.  Neurotoxicity of Aβ amyloid protein in vitro is not altered by calcium channel blockade , 1995, Neurobiology of Aging.

[98]  C. Cotman,et al.  Calretinin-immunoreactive neurons are resistant to β-amyloid toxicity in vitro , 1995, Brain Research.

[99]  D. Price,et al.  Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus. , 1995, The American journal of pathology.

[100]  J. Morley,et al.  An amyloid β-protein fragment, Aβ[12–28], equipotently impairs post-training memory processing when injected into different limbic system structures , 1994, Brain Research.

[101]  Patrizia Mecocci,et al.  Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease , 1994, Annals of neurology.

[102]  T. Holzman,et al.  Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths. , 1994, Biophysical journal.

[103]  L. Thal,et al.  Lack of long-term effects after β-amyloid protein injections in rat brain , 1994, Neurobiology of Aging.

[104]  I. Lieberburg,et al.  Channel formation in planar lipid bilayers by a neurotoxic fragment of the beta-amyloid peptide. , 1994, Biochemical and biophysical research communications.

[105]  C. Behl,et al.  Hydrogen peroxide mediates amyloid β protein toxicity , 1994, Cell.

[106]  W. Müller,et al.  Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity. , 1994, Biochemical and biophysical research communications.

[107]  C. Behl,et al.  Amyloid β peptide induces necrosis rather than apoptosis , 1994, Brain Research.

[108]  P. Greengard,et al.  Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. , 1994, The Journal of biological chemistry.

[109]  M. Mattson,et al.  A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[110]  M. Mattson.  Secreted forms of beta-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons. , 1994, Journal of neurobiology.

[111]  D. Walker,et al.  Involvement of microglia in Alzheimer's disease. , 1994, Neuropathology and applied neurobiology.

[112]  T. Hasegawa,et al.  β-Amyloid protein-induced Alzheimer's disease animal model , 1994, Neuroscience Letters.

[113]  L. Giovannelli,et al.  Administration of amyloid β-peptides into the medial septum of rats decreases acetylcholine release from hippocampus in vivo , 1994, Brain Research.

[114]  G. Schneider,et al.  The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis. , 1994, Developmental biology.

[115]  B. Winblad,et al.  beta-Amyloid related peptides exert differential effects on [3H]MK-801 binding to rat cortical membranes. , 1994, Neuroreport.

[116]  J. Morley,et al.  Topography of a binding site for small amnestic peptides deduced from structure-activity studies: relation to amnestic effect of amyloid beta protein. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[117]  C. Cotman,et al.  Rapid Communication: Ca2+ Channel Blockers Attenuate β‐Amyloid Peptide Toxicity to Cortical Neurons in Culture , 1994 .

[118]  D. Selkoe,et al.  Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide , 1993, Cell.

[119]  M. Mattson,et al.  Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF , 1993, Brain Research.

[120]  B. Ames,et al.  Oxidants, antioxidants, and the degenerative diseases of aging. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[121]  D. Selkoe,et al.  Normal Cellular Processing of the β‐Amyloid Precursor Protein Results in the Secretion of the Amyloid β Peptide and Related Molecules a , 1993 .

[122]  C. Cotman,et al.  Cultured GABA-immunoreactive neurons are resistant to toxicity induced by β-amyloid , 1993, Neuroscience.

[123]  D. Schubert,et al.  Amyloid beta-protein activates tachykinin receptors and inositol trisphosphate accumulation by synergy with glutamate. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[124]  Carl W. Cotman,et al.  Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[125]  I. Nishimoto,et al.  Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go , 1993, Nature.

[126]  E. Rojas,et al.  Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[127]  T. Bliss,et al.  A synaptic model of memory: long-term potentiation in the hippocampus , 1993, Nature.

[128]  H. Okado,et al.  A Xenopus homologue of the human β-amyloid precursor protein: Development regulation of its gene expression , 1992 .

[129]  J. Reed,et al.  Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides. , 1992, Journal of molecular biology.

[130]  D. Selkoe,et al.  Amyloid β-peptide is produced by cultured cells during normal metabolism , 1992, Nature.

[131]  D. K. Rush,et al.  Intracerebral /sB-amyloid(25–35) produces tissue damage: Is it neurotoxic? , 1992, Neurobiology of Aging.

[132]  I. Lieberburg,et al.  Lack of alzheimer pathology after β-amyloid protein injections in rat brain , 1992, Neurobiology of Aging.

[133]  R. Sapolsky,et al.  Failure of beta-amyloid protein fragment 25–35 to cause hippocampal damage in the rat , 1992, Neurobiology of Aging.

[134]  C. Geula,et al.  The acute neurotoxicity and effects upon cholinergic axons of intracerebrally injected β-amyloid in the rat brain , 1992, Neurobiology of Aging.

[135]  D. Stephenson,et al.  Implants containing β-amyloid protein are not neurotoxic to young and old rat brain , 1992, Neurobiology of Aging.

[136]  G. Cole,et al.  Vitamin E protects nerve cells from amyloid βprotein toxicity , 1992 .

[137]  M. Mattson,et al.  beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[138]  B. Strooper,et al.  The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported. , 1991 .

[139]  G. Cole,et al.  Effects of injected Alzheimer beta-amyloid cores in rat brain. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[140]  M. Beal,et al.  An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[141]  S. Little,et al.  Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis. , 1991, Brain research. Molecular brain research.

[142]  J. Morley,et al.  Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[143]  D. Selkoe.  The molecular pathology of Alzheimer's disease , 1991, Neuron.

[144]  J. Reed,et al.  Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease , 1991 .

[145]  E. Stadtman,et al.  Metal-catalyzed oxidation of proteins. Physiological consequences. , 1991, The Journal of biological chemistry.

[146]  M. Mattson,et al.  Evidence for calcium-reducing and excitoprotective roles for the calcium-binding protein calbindin-1328k in cultured hippocampal neurons , 1991, Neuron.

[147]  C. Cotman,et al.  β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage , 1990, Brain Research.

[148]  D. Kirschner,et al.  Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. , 1990, Science.

[149]  D. Price,et al.  Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. , 1990, Science.

[150]  L. Villa-komaroff,et al.  Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. , 1989, Science.

[151]  S. Pulst,et al.  The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05. , 1989, Genomics.

[152]  C. Cotman,et al.  Amyloid beta protein enhances the survival of hippocampal neurons in vitro. , 1989, Science.

[153]  Y. Sakaki,et al.  Complementary DNA for the mouse homolog of the human amyloid beta protein precursor. , 1987, Biochemical and biophysical research communications.

[154]  B. Halliwell.  Oxidants and human disease: some new concepts 1 , 1987, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[155]  P. Luiten,et al.  Cortical projection patterns of magnocellular basal nucleus subdivisions as revealed by anterogradely transportedPhaseolus vulgaris leucoagglutinin , 1987, Brain Research.

[156]  K. Grzeschik,et al.  The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor , 1987, Nature.

[157]  C. Masters,et al.  Amyloid plaque core protein in Alzheimer disease and Down syndrome. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[158]  G. Glenner,et al.  Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. , 1984, Biochemical and biophysical research communications.

[159]  G. Glenner,et al.  Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein , 1984 .

[160]  R. Bartus,et al.  The cholinergic hypothesis of geriatric memory dysfunction. , 1982, Science.

[161]  M. Mattson,et al.  Roles of Lipid Peroxidation in Modulation of Cellular Signaling Pathways, Cell Dysfunction, and Death in the Nervous System , 1998, Reviews in the neurosciences.

[162]  M. Beal,et al.  The neurotoxicity of amyloid beta protein in aged primates. , 1998, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

[163]  M. Barcikowska,et al.  Transport of Human β-Amyloid Peptide Through the Rat Blood-Brain Barrier After Global Cerebral Ischemia , 1997 .

[164]  C. Nyakas,et al.  Combined Therapy with 8-OH-DPAT and Nimodipine Against in Vivo NMDA-Induced Cell Death in Rat Nucleus Basalis , 1997 .

[165]  T. Poulos,et al.  Aspartate residue 7 in amyloid β-protein is critical for classical complement pathway activation: Implications for Alzheimer's disease pathogenesis , 1997, Nature Medicine.

[166]  C. Nyakas,et al.  Calcium Homeostasis, Nimodipine, and Stroke , 1997 .

[167]  W R Markesbery,et al.  Oxidative stress hypothesis in Alzheimer's disease. , 1997, Free radical biology & medicine.

[168]  V. Bigl,et al.  Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction. , 1996, Progress in brain research.

[169]  P. Kostyuk,et al.  Calcium Signalling in the Nervous System , 1995 .

[170]  D. Selkoe,et al.  Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity. , 1993, The American journal of pathology.

[171]  X. Chen,et al.  Amyloid- (cid:98) peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease , 1997 .