Risk groups in children under six months of age using self-organizing maps

Fetal and infant growth tends to follow irregular patterns and, particularly in developing countries, these patterns are greatly influenced by unfavorable living conditions and interactions with complications during pregnancy. The aim of this study was to identify groups of children with different risk profiles for growth development. The study sample comprised 496 girls and 508 boys under six months of age from 27 pediatric primary health care units in the city of Rio de Janeiro, Brazil. Data were obtained through interviews with the mothers and by reviewing each child's health card. An unsupervised learning, know as a self-organizing map (SOM) and a K-means algorithm were used for cluster analysis to identify groups of children. Four groups of infants were identified. The first (139) consisted of infants born exclusively by cesarean delivery, and their mothers were exclusively multiparous; the highest prevalences of prematurity and low birthweight, a high prevalence of exclusive breastfeeding and a low proportion of hospitalization were observed for this group. The second (247 infants) and the third (298 infants) groups had the best and worst perinatal and infant health indicators, respectively. The infants of the fourth group (318) were born heavier, had a low prevalence of exclusive breastfeeding, and had a higher rate of hospitalization. Using a SOM, it was possible to identify children with common features, although no differences between groups were found with respect to the adequacy of postnatal weight. Pregnant women and children with characteristics similar to those of group 3 require early intervention and more attention in public policy.

[1]  M. Lizán-García,et al.  Full Breastfeeding and Hospitalization as a Result of Infections in the First Year of Life , 2006, Pediatrics.

[2]  H. S. Maranhão,et al.  Postnatal growth restriction and predictors of nutritional outcome in very low birth weight infants fed human milk and assisted by the Kangaroo Mother Care method , 2013, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[3]  Infant feeding and hospitalization during the first six months of life. , 2007, JPMA. The Journal of the Pakistan Medical Association.

[4]  Juan Julián Merelo Guervós,et al.  Clustering and Visualizing HIV Quasispecies Using Kohonen's Self-Organizing Maps , 2007, IWANN.

[5]  A. Sacker,et al.  Breastfeeding and Hospitalization for Diarrheal and Respiratory Infection in the United Kingdom Millennium Cohort Study , 2007, Pediatrics.

[6]  N. Madise,et al.  Patterns and determinants of breastfeeding and complementary feeding practices in urban informal settlements, Nairobi Kenya , 2011, BMC public health.

[7]  F. Barros,et al.  Developmental status at age 12 months according to birth weight and family income: a comparison of two Brazilian birth cohorts. , 2008, Cadernos de saude publica.

[8]  M. Onis,et al.  [WHO growth standards for infants and young children]. , 2009, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[9]  Teuvo Kohonen,et al.  The self-organizing map , 1990 .

[10]  T. Tylleskär,et al.  Determinants of infant growth in Eastern Uganda: a community-based cross-sectional study , 2008, BMC public health.

[11]  Márcia Furquim de Almeida,et al.  Mortalidade neonatal no Município de São Paulo: influência do peso ao nascer e de fatores sócio-demográficos e assistenciais , 2002 .

[12]  C. Victora,et al.  Explaining trends in inequities: evidence from Brazilian child health studies , 2000, The Lancet.

[13]  L. Monasta,et al.  Early-life determinants of overweight and obesity: a review of systematic reviews , 2011 .

[14]  R. Martorell,et al.  Short-term benefits of catch-up growth for small-for-gestational-age infants. , 2001, International journal of epidemiology.

[15]  Colin Fyfe,et al.  Topology-Preserving Mappings for Data Visualisation , 2008 .

[16]  B. Kirkwood,et al.  Infant feeding patterns and risks of death and hospitalization in the first half of infancy: multicentre cohort study. , 2005, Bulletin of the World Health Organization.

[17]  Anil K. Jain,et al.  Data clustering: a review , 1999, CSUR.

[18]  S. Morris,et al.  Do childhood growth indicators in developing countries cluster? Implications for intervention strategies , 2004, Public Health Nutrition.

[19]  C. A. Monteiro,et al.  Evolução da assistência materno-infantil na cidade de São Paulo (1984-1996) , 2000 .

[20]  H. Pan,et al.  WHO child growth standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age , 2006 .

[21]  Simon Haykin,et al.  Neural Networks and Learning Machines , 2010 .

[22]  Ken P Kleinman,et al.  Infant Growth Before and After Term: Effects on Neurodevelopment in Preterm Infants , 2011, Pediatrics.

[23]  S. Gama,et al.  [Use of the modified Kotelchuck index in the evaluation of prenatal care and its relationship to maternal characteristics and birth weight in Rio de Janeiro, Brazil]. , 2004, Cadernos de saude publica.

[24]  Eleonora D’orsi,et al.  Factors associated with cesarean section rates in a university hospital , 2009 .

[25]  Alberto Prieto,et al.  Computational and ambient intelligence , 2009, Neurocomputing.

[26]  Mikko Kolehmainen,et al.  Insulin resistance syndrome revisited: application of self-organizing maps. , 2002, International journal of epidemiology.

[27]  Shumei S. Guo,et al.  2000 CDC Growth Charts for the United States: methods and development. , 2002, Vital and health statistics. Series 11, Data from the National Health Survey.

[28]  Paulo J. G. Lisboa,et al.  A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients , 2010, Comput. Biol. Medicine.

[29]  Kimmo Kiviluoto,et al.  Topology preservation in self-organizing maps , 1996, Proceedings of International Conference on Neural Networks (ICNN'96).

[30]  V. Han,et al.  Determinants of small for gestational age birth at term. , 2012, Paediatric and perinatal epidemiology.

[31]  A. Barros,et al.  Gestational age at birth and morbidity, mortality, and growth in the first 4 years of life: findings from three birth cohorts in Southern Brazil , 2012, BMC Pediatrics.

[32]  Marília Sá Carvalho,et al.  Fatores que interferem no tempo entre o nascimento e a primeira mamada , 2008 .

[33]  Robert Tibshirani,et al.  Estimating the number of clusters in a data set via the gap statistic , 2000 .

[34]  L. Hui,et al.  Determinants of infant growth: Evidence from Hong Kong's "Children of 1997" birth cohort. , 2010, Annals of epidemiology.

[35]  J. Brug,et al.  Early‐life determinants of overweight and obesity: a review of systematic reviews , 2010, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[36]  J. Cecatti,et al.  Perinatal outcomes associated with low birth weight in a historical cohort , 2011, Reproductive health.

[37]  P. Boccolini,et al.  Breastfeeding can prevent hospitalization for pneumonia among children under 1 year old. , 2011, Jornal de pediatria.

[38]  Esa Alhoniemi,et al.  Clustering of the self-organizing map , 2000, IEEE Trans. Neural Networks Learn. Syst..

[39]  R. Martorell,et al.  Growth Patterns in Early Childhood and Final Attained Stature: Data from Five Birth Cohorts from Low- and Middle-Income Countries , 2009, American journal of human biology : the official journal of the Human Biology Council.

[40]  Leanne Whiteside-Mansell,et al.  Impact of Prenatal and/or Postnatal Growth Problems in Low Birth Weight Preterm Infants on School-Age Outcomes: An 8-Year Longitudinal Evaluation , 2006, Pediatrics.

[41]  S. Philippi,et al.  [Child health and nutrition in a Teréna indigenous community, Mato Grosso do Sul, Brazil]. , 2001, Cadernos de saude publica.

[42]  Fernando Bação,et al.  Self-organizing Maps as Substitutes for K-Means Clustering , 2005, International Conference on Computational Science.

[43]  Jack Dongarra,et al.  Computational Science - ICCS 2005, 5th International Conference, Atlanta, GA, USA, May 22-25, 2005, Proceedings, Part I , 2005, International Conference on Computational Science.

[44]  E. Declercq,et al.  Effect of Late-Preterm Birth and Maternal Medical Conditions on Newborn Morbidity Risk , 2008, Pediatrics.

[45]  E. d’Orsi,et al.  [Factors associated with cesarean section rates in a university hospital]. , 2009, Revista de saude publica.

[46]  Robert W Platt,et al.  Breastfeeding and infant growth: biology or bias? , 2002, Pediatrics.

[47]  E. Schwarz,et al.  Breastfeeding and the risk of hospitalization for respiratory disease in infancy: a meta-analysis. , 2003, Archives of pediatrics & adolescent medicine.

[48]  G. Kac,et al.  [Factors accountable for macrosomia incidence in a study with mothers and progeny attended at a Basic Unity of Health in Rio de Janeiro, Brazil]. , 2008, Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia.

[49]  Fatimah Ibrahim,et al.  Reexamination of risk criteria in dengue patients using the self-organizing map , 2010, Medical & Biological Engineering & Computing.

[50]  Shumei S. Guo,et al.  CDC GROWTH CHARTS FOR THE UNITED STATES: METHODS AND DEVELOPMENT 2000 , 2002 .

[51]  R. Martorell,et al.  Size at birth, weight gain in infancy and childhood, and adult blood pressure in 5 low- and middle-income-country cohorts: when does weight gain matter?123 , 2009, The American journal of clinical nutrition.

[52]  A. Barros,et al.  Narrowing socioeconomic inequality in child stunting: the Brazilian experience, 1974-2007. , 2010, Bulletin of the World Health Organization.

[53]  C. Struchiner,et al.  [Breastfeeding practices and infant growth: a longitudinal study in Rio de Janeiro, Brazil, 1999/2001]. , 2005, Cadernos de saude publica.

[54]  T. Cole,et al.  Impaired growth in infants born to mothers of very high parity. , 1987, Human nutrition. Clinical nutrition.

[55]  G. A. P. Silva,et al.  [Does birth weight affect nutritional status at the end of first year of life?]. , 2005, Jornal de pediatria.

[56]  L. Caulfield,et al.  Exclusive breastfeeding reduces acute respiratory infection and diarrhea deaths among infants in Dhaka slums. , 2001, Pediatrics.

[57]  F. Bastos,et al.  State of animus among Brazilians: influence of socioeconomic context? , 2005, Cadernos de saude publica.

[58]  Ken P. Kleinman,et al.  Weight Status in the First 6 Months of Life and Obesity at 3 Years of Age , 2009, Pediatrics.

[59]  Maria Inês Couto de Oliveira,et al.  O papel do aleitamento materno na redução das hospitalizações por pneumonia em crianças brasileiras menores de 1 ano , 2011 .

[60]  M. Heinig,et al.  Risk factors for suboptimal infant breastfeeding behavior, delayed onset of lactation, and excess neonatal weight loss. , 2003, Pediatrics.

[61]  P. I. C. Lira,et al.  Fatores determinantes do crescimento infantil , 2004 .

[62]  B. Duncan,et al.  Evaluation of the ability of a Latin‐American gestational weight curve to predict adverse pregnancy outcomes , 2009, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[63]  Pauline M Emmett,et al.  Size at Birth and Early Childhood Growth in Relation to Maternal Smoking, Parity and Infant Breast-Feeding: Longitudinal Birth Cohort Study and Analysis , 2002, Pediatric Research.

[64]  W M Moore,et al.  Physical growth: National Center for Health Statistics percentiles. , 1979, The American journal of clinical nutrition.

[65]  Joseph Y. Lo,et al.  Self-organizing map for cluster analysis of a breast cancer database , 2003, Artif. Intell. Medicine.