Industry 4.0 and Health: Internet of Things, Big Data, and Cloud Computing for Healthcare 4.0

Abstract Industry 4.0 and its main enabling information and communication technologies are completely changing both services and production worlds. This is especially true for the health domain, where the Internet of Things, Cloud and Fog Computing, and Big Data technologies are revolutionizing eHealth and its whole ecosystem, moving it towards Healthcare 4.0. By selectively analyzing the literature, we systematically survey how the adoption of the above-mentioned Industry 4.0 technologies (and their integration) applied to the health domain is changing the way to provide traditional services and products. In this paper, we provide (i) a description of the main technologies and paradigms in relation to Healthcare 4.0 and discuss (ii) their main application scenarios; we then provide an analysis of (iii) carried benefits and (iv) novel cross-disciplinary challenges; finally, we extract (v) the lessons learned.

[1]  Ilias Maglogiannis,et al.  Bringing IoT and Cloud Computing towards Pervasive Healthcare , 2012, 2012 Sixth International Conference on Innovative Mobile and Internet Services in Ubiquitous Computing.

[2]  Roy D. Sleator,et al.  'Big data', Hadoop and cloud computing in genomics , 2013, J. Biomed. Informatics.

[3]  Alvar Agusti,et al.  P4 Medicine: the Future Around the Corner , 2011 .

[4]  Athanasios V. Vasilakos,et al.  A review of industrial wireless networks in the context of Industry 4.0 , 2015, Wireless Networks.

[5]  Venet Osmani,et al.  Human activity recognition in pervasive health-care: Supporting efficient remote collaboration , 2008, J. Netw. Comput. Appl..

[6]  M. Shamim Hossain,et al.  Cloud-Assisted Speech and Face Recognition Framework for Health Monitoring , 2015, Mobile Networks and Applications.

[7]  László Monostori,et al.  A survey of applications and requirements of unique identification systems and RFID techniques , 2011, Comput. Ind..

[8]  Jian Weng,et al.  A novel asymmetric three-party based authentication scheme in wearable devices environment , 2016, J. Netw. Comput. Appl..

[9]  Willian D. de Mattos,et al.  M-Health Solutions Using 5G Networks and M2M Communications , 2016, IT Professional.

[10]  Prajakta Kulkarni,et al.  mPHASiS: Mobile patient healthcare and sensor information system , 2011, J. Netw. Comput. Appl..

[11]  UllahSana,et al.  A Comprehensive Survey of Wireless Body Area Networks , 2012 .

[12]  Yi Chen,et al.  Real-Time or Near Real-Time Persisting Daily Healthcare Data Into HDFS and ElasticSearch Index Inside a Big Data Platform , 2017, IEEE Transactions on Industrial Informatics.

[13]  Luís Velez Lapão,et al.  The Promise of the Internet of Things in Healthcare: How Hard Is It to Keep? , 2016, MIE.

[14]  Andrea C. Arpaci-Dusseau,et al.  Serverless Computation with OpenLambda , 2016, HotCloud.

[15]  Huosheng Hu,et al.  Human motion tracking for rehabilitation - A survey , 2008, Biomed. Signal Process. Control..

[16]  Aleksandar Milenkovic,et al.  Body Area Networks for Ubiquitous Healthcare Applications: Opportunities and Challenges , 2011, Journal of Medical Systems.

[17]  Antonio Iera,et al.  Understanding the Internet of Things: definition, potentials, and societal role of a fast evolving paradigm , 2017, Ad Hoc Networks.

[18]  Niraj K. Jha,et al.  Internet-of-Medical-Things , 2017, ACM Great Lakes Symposium on VLSI.

[19]  Nabil Ahmed Sultan,et al.  Making use of cloud computing for healthcare provision: Opportunities and challenges , 2014, Int. J. Inf. Manag..

[20]  Giuseppe Aceto,et al.  A Survey on Information and Communication Technologies for Industry 4.0: State-of-the-Art, Taxonomies, Perspectives, and Challenges , 2019, IEEE Communications Surveys & Tutorials.

[21]  Xingda Qu,et al.  A systematic review and meta-analysis of user acceptance of consumer-oriented health information technologies , 2020, Comput. Hum. Behav..

[22]  Neeraj Kumar,et al.  Fog computing for Healthcare 4.0 environment: Opportunities and challenges , 2018, Comput. Electr. Eng..

[23]  Phillip A. Laplante,et al.  A Structured approach for describing healthcare applications for the Internet of Things , 2015, 2015 IEEE 2nd World Forum on Internet of Things (WF-IoT).

[24]  Andrés Marín López,et al.  Collaborative eHealth Meets Security: Privacy-Enhancing Patient Profile Management , 2017, IEEE Journal of Biomedical and Health Informatics.

[25]  Cathy O'Neil,et al.  Weapons of Math Destruction: How Big Data Increases Inequality and Threatens Democracy , 2016, Vikalpa: The Journal for Decision Makers.

[26]  Pan Li,et al.  Cloud-Assisted Mobile-Access of Health Data With Privacy and Auditability , 2014, IEEE Journal of Biomedical and Health Informatics.

[27]  Hyejung Chang,et al.  Big Data and Healthcare: Building an Augmented World , 2016, Healthcare informatics research.

[28]  Solon Barocas,et al.  Engaging the ethics of data science in practice , 2017, Commun. ACM.

[29]  Hans-Georg Kemper,et al.  Application-Pull and Technology-Push as Driving Forces for the Fourth Industrial Revolution , 2014 .

[30]  Rajkumar Buyya,et al.  Fog Computing: Helping the Internet of Things Realize Its Potential , 2016, Computer.

[31]  Mahadev Satyanarayanan,et al.  Towards wearable cognitive assistance , 2014, MobiSys.

[32]  Abdallah Makhoul,et al.  Self-Adaptive Data Collection and Fusion for Health Monitoring Based on Body Sensor Networks , 2016, IEEE Transactions on Industrial Informatics.

[33]  Xiaoya Xu,et al.  Wireless Body Sensor Networks with Cloud Computing Capability for Pervasive Healthcare: Research Directions and Possible Solutions , 2014 .

[34]  Gunasekaran Manogaran,et al.  Big Data Security Intelligence for Healthcare Industry 4.0 , 2017 .

[35]  Shyamal Patel,et al.  A review of wearable sensors and systems with application in rehabilitation , 2012, Journal of NeuroEngineering and Rehabilitation.

[36]  Mazliza Othman,et al.  Internet of Things security: A survey , 2017, J. Netw. Comput. Appl..

[37]  Francisco Almada-Lobo,et al.  The Industry 4.0 revolution and the future of Manufacturing Execution Systems (MES) , 2016 .

[38]  Joaquín B. Ordieres Meré,et al.  Smart factories in Industry 4.0: A review of the concept and of energy management approached in production based on the Internet of Things paradigm , 2014, 2014 IEEE International Conference on Industrial Engineering and Engineering Management.

[39]  JongHyun Park,et al.  A study on the potential needs and market promotion of smart health in Korea , 2013, 2013 International Conference on ICT Convergence (ICTC).

[40]  O. Geman,et al.  Adopting the Internet of Things technologies in health care systems , 2014, 2014 International Conference and Exposition on Electrical and Power Engineering (EPE).

[41]  Katinka Wolter,et al.  Mobile Healthcare Systems with Multi-cloud Offloading , 2013, 2013 IEEE 14th International Conference on Mobile Data Management.

[42]  Ilias Maglogiannis,et al.  Mobile healthcare information management utilizing Cloud Computing and Android OS , 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology.

[43]  Yu-Yi Chen,et al.  A Secure EHR System Based on Hybrid Clouds , 2012, Journal of Medical Systems.

[44]  Abdelfettah Belghith,et al.  Wireless Body Area Networks: Applications and Technologies , 2016, ANT/SEIT.

[45]  Shusen Yang,et al.  A survey on the ietf protocol suite for the internet of things: standards, challenges, and opportunities , 2013, IEEE Wireless Communications.

[46]  Hui Wang,et al.  The fog computing service for healthcare , 2015, 2015 2nd International Symposium on Future Information and Communication Technologies for Ubiquitous HealthCare (Ubi-HealthTech).

[47]  A. Sanna,et al.  An internet of things enabled interactive totem for children in a living lab setting , 2012, 2012 18th International ICE Conference on Engineering, Technology and Innovation.

[48]  Niina Keränen,et al.  IEEE802.15.6 -based multi-accelerometer WBAN system for monitoring Parkinson's disease , 2013, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[49]  Shiping Chen,et al.  A platform for secure monitoring and sharing of generic health data in the Cloud , 2014, Future Gener. Comput. Syst..

[50]  Yao Zheng,et al.  Scalable and Secure Sharing of Personal Health Records in Cloud Computing Using Attribute-Based Encryption , 2019, IEEE Transactions on Parallel and Distributed Systems.

[51]  R. Weinstein,et al.  Telepathology: a ten-year progress report. , 1997, Human pathology.

[52]  Arshdeep Bahga,et al.  A Cloud-based Approach for Interoperable Electronic Health Records (EHRs) , 2013, IEEE Journal of Biomedical and Health Informatics.

[53]  Mary Boulton,et al.  Development of an e-health app to support women prescribed adjuvant endocrine therapy after treatment for breast cancer , 2018, Patient preference and adherence.

[54]  BottaAlessio,et al.  Integration of Cloud computing and Internet of Things , 2016 .

[55]  E. A. Mary Anita,et al.  A Survey of Big Data Analytics in Healthcare and Government , 2015 .

[56]  Torbjørn S. Dahl,et al.  Robots in Health and Social Care: A Complementary Technology to Home Care and Telehealthcare? , 2013, Robotics.

[57]  E. Schadt The changing privacy landscape in the era of big data , 2012, Molecular systems biology.

[58]  Gennaro Boggia,et al.  Standardized Protocol Stack for the Internet of (Important) Things , 2013, IEEE Communications Surveys & Tutorials.

[59]  Benjamin Fabian,et al.  Collaborative and secure sharing of healthcare data in multi-clouds , 2015, Inf. Syst..

[60]  Jerome Couturier,et al.  How Can the Internet of Things Help to Overcome Current Healthcare Challenges , 2012 .

[61]  Victor C. M. Leung,et al.  Enabling technologies for wireless body area networks: A survey and outlook , 2009, IEEE Communications Magazine.

[62]  Luciano Floridi,et al.  Transparent, explainable, and accountable AI for robotics , 2017, Science Robotics.

[63]  Antonio Pescapè,et al.  Integration of Cloud computing and Internet of Things: A survey , 2016, Future Gener. Comput. Syst..

[64]  Jit Biswas,et al.  Processing of wearable sensor data on the cloud - a step towards scaling of continuous monitoring of health and well-being , 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology.

[65]  E C Nice,et al.  From proteomics to personalized medicine: the road ahead , 2016, Expert review of proteomics.

[66]  Qiang Chen,et al.  A Health-IoT Platform Based on the Integration of Intelligent Packaging, Unobtrusive Bio-Sensor, and Intelligent Medicine Box , 2014, IEEE Transactions on Industrial Informatics.

[67]  Carmelo Pino,et al.  A Survey of Cloud Computing Architecture and Applications in Health , 2013 .

[68]  Claes Wohlin,et al.  Guidelines for snowballing in systematic literature studies and a replication in software engineering , 2014, EASE '14.

[69]  Ke Chen,et al.  Survey of MapReduce frame operation in bioinformatics , 2013, Briefings Bioinform..

[70]  RahayuWenny,et al.  Mobile cloud computing , 2013 .

[71]  Marek Obitko,et al.  Understanding Data Heterogeneity in the Context of Cyber-Physical Systems Integration , 2017, IEEE Transactions on Industrial Informatics.

[72]  Ingrid Moerman,et al.  A Comprehensive Survey of Wireless Body Area Networks , 2012, Journal of Medical Systems.

[73]  Bruno M. C. Silva,et al.  An IoT-based mobile gateway for intelligent personal assistants on mobile health environments , 2016, J. Netw. Comput. Appl..

[74]  Joel J. P. C. Rodrigues,et al.  Body Sensor Network Mobile Solutions for Biofeedback Monitoring , 2011, Mob. Networks Appl..

[75]  Ning Zhang,et al.  An Open, Secure and Flexible Platform Based on Internet of Things and Cloud Computing for Ambient Aiding Living and Telemedicine , 2011, 2011 International Conference on Computer and Management (CAMAN).

[76]  Christoph Thuemmler,et al.  Health 4.0: How Virtualization and Big Data are Revolutionizing Healthcare , 2017 .

[77]  Viju Raghupathi,et al.  Big data analytics in healthcare: promise and potential , 2014, Health Information Science and Systems.

[78]  Mingzhe Jiang,et al.  Fog Computing in Healthcare Internet of Things: A Case Study on ECG Feature Extraction , 2015, 2015 IEEE International Conference on Computer and Information Technology; Ubiquitous Computing and Communications; Dependable, Autonomic and Secure Computing; Pervasive Intelligence and Computing.

[79]  William J. Buchanan,et al.  An Integrated Cloud-based Healthcare Infrastructure , 2011, 2011 IEEE Third International Conference on Cloud Computing Technology and Science.

[80]  JaeHo Lee Smart health: Concepts and status of ubiquitous health with smartphone , 2011, ICTC 2011.

[81]  Claudia Linnhoff-Popien,et al.  Mobile Edge Computing , 2016, Informatik-Spektrum.

[82]  Chao-Tung Yang,et al.  Implementation of a Medical Image File Accessing System on Cloud Computing , 2010, 2010 13th IEEE International Conference on Computational Science and Engineering.

[83]  Joel J. P. C. Rodrigues,et al.  Intra-body Temperature Monitoring Using a Biofeedback Solution , 2010, 2010 Second International Conference on eHealth, Telemedicine, and Social Medicine.

[84]  Xianghan Zheng,et al.  Lightweight distributed secure data management system for health internet of things , 2017, J. Netw. Comput. Appl..

[85]  Rui Chen,et al.  Promise of personalized omics to precision medicine , 2013, Wiley interdisciplinary reviews. Systems biology and medicine.

[86]  Michael Weyrich,et al.  Reference Architectures for the Internet of Things , 2016, IEEE Software.

[87]  Alexander Verl,et al.  Making existing production systems Industry 4.0-ready , 2015, Prod. Eng..

[88]  Xi Jin,et al.  A cloud computing solution for Hospital Information System , 2010, 2010 IEEE International Conference on Intelligent Computing and Intelligent Systems.

[89]  Wei Cai,et al.  ROCHAS: Robotics and Cloud-assisted Healthcare System for Empty Nester , 2013, BODYNETS.

[90]  Sanjay P. Ahuja,et al.  A Survey of the State of Cloud Computing in Healthcare , 2012, Netw. Commun. Technol..

[91]  R. S. H. Istepanian,et al.  The potential of Internet of m-health Things “m-IoT” for non-invasive glucose level sensing , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[92]  L. Hood,et al.  A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory. , 2012, New biotechnology.

[93]  Fabrício F. Costa Big data in biomedicine. , 2014, Drug discovery today.

[94]  Kyung-Sup Kwak,et al.  The Internet of Things for Health Care: A Comprehensive Survey , 2015, IEEE Access.

[95]  Lucy Yardley,et al.  Understanding acceptability of and engagement with Web‐based interventions aiming to improve quality of life in cancer survivors: A synthesis of current research , 2018, Psycho-oncology.

[96]  Yuehong Yin,et al.  The internet of things in healthcare: An overview , 2016, J. Ind. Inf. Integr..

[97]  Melody Moh,et al.  A Prototype on RFID and Sensor Networks for Elder Health Care , 2017 .

[98]  C. L. Ventola Mobile devices and apps for health care professionals: uses and benefits. , 2014, P & T : a peer-reviewed journal for formulary management.

[99]  Darcy A. Davis,et al.  Bringing Big Data to Personalized Healthcare: A Patient-Centered Framework , 2013, Journal of General Internal Medicine.

[100]  OthmanMazliza,et al.  Internet of Things security , 2017 .

[101]  Joel J. P. C. Rodrigues,et al.  Mobile-health: A review of current state in 2015 , 2015, J. Biomed. Informatics.

[102]  Martina Ziefle,et al.  From Smart Health to Smart Hospitals , 2015, Smart Health.

[103]  Chinmay Chakraborty,et al.  A review on telemedicine-based WBAN framework for patient monitoring. , 2013, Telemedicine journal and e-health : the official journal of the American Telemedicine Association.

[104]  Thomas Magedanz,et al.  Applying the Software-to-Data Paradigm in Next Generation E-Health Hybrid Clouds , 2013, 2013 10th International Conference on Information Technology: New Generations.

[105]  Pieter Abbeel,et al.  Image Object Label 3 D CAD Model Candidate Grasps Google Object Recognition Engine Google Cloud Storage Select Feasible Grasp with Highest Success Probability Pose EstimationCamera Robots Cloud 3 D Sensor , 2014 .

[106]  Inderveer Chana,et al.  Cloud based intelligent system for delivering health care as a service , 2014, Comput. Methods Programs Biomed..

[107]  R. DarshanK,et al.  A comprehensive review on usage of Internet of Things (IoT) in healthcare system , 2015 .

[108]  J. Wenny Rahayu,et al.  Mobile cloud computing: A survey , 2013, Future Gener. Comput. Syst..

[109]  Manuel de Buenaga Rodríguez,et al.  Integrating Internet of Things and Cloud Computing for Health Services Provisioning: The Virtual Cloud Carer Project , 2012, 2012 Sixth International Conference on Innovative Mobile and Internet Services in Ubiquitous Computing.

[110]  Zhanpeng Jin,et al.  HeartToGo: A Personalized medicine technology for cardiovascular disease prevention and detection , 2009, 2009 IEEE/NIH Life Science Systems and Applications Workshop.

[111]  M. Bamiah,et al.  A study on significance of adopting cloud computing paradigm in healthcare sector , 2012, 2012 International Conference on Cloud Computing Technologies, Applications and Management (ICCCTAM).

[112]  Taghi M. Khoshgoftaar,et al.  A review of data mining using big data in health informatics , 2013, Journal Of Big Data.

[113]  Alfred Ma,et al.  How cloud computing and social media are changing the face of health care. , 2013, Physician executive.

[114]  Athanasios V. Vasilakos,et al.  Body Area Networks: A Survey , 2010, Mob. Networks Appl..

[115]  Lifeng Zhou,et al.  Industry 4.0: Towards future industrial opportunities and challenges , 2015, 2015 12th International Conference on Fuzzy Systems and Knowledge Discovery (FSKD).

[116]  Mario Cannataro,et al.  Cloud Computing in Healthcare and Biomedicine , 2015, Scalable Comput. Pract. Exp..

[117]  Geng Yang,et al.  Wearable Internet of Things: Concept, architectural components and promises for person-centered healthcare , 2014 .

[118]  Manuel Rodríguez-Martínez,et al.  MedBook: A Cloud-Based Healthcare Billing and Record Management System , 2012, 2012 IEEE Fifth International Conference on Cloud Computing.

[119]  Vladimir Vujovic,et al.  The Future of Healthcare: Nanomedicine and Internet of Nano Things , 2015 .

[120]  Juan I. Nieto-Hipólito,et al.  A proposal for using the internet of things concept to increase children's health awareness , 2012, CONIELECOMP 2012, 22nd International Conference on Electrical Communications and Computers.

[121]  Ahmad-Reza Sadeghi,et al.  Security and privacy challenges in industrial Internet of Things , 2015, 2015 52nd ACM/EDAC/IEEE Design Automation Conference (DAC).

[122]  Paramvir Bahl,et al.  The Case for VM-Based Cloudlets in Mobile Computing , 2009, IEEE Pervasive Computing.

[123]  Dharavath Ramesh,et al.  Big data analytics in healthcare: A survey approach , 2016, 2016 International Conference on Microelectronics, Computing and Communications (MicroCom).

[124]  A. Annunziato 5G Vision: NGMN - 5G Initiative , 2015, 2015 IEEE 81st Vehicular Technology Conference (VTC Spring).

[125]  Theofanis Orphanoudakis,et al.  Integrating IoT and Fog Computing for Healthcare Service Delivery , 2017 .

[126]  Xiaohui Liang,et al.  ESPAC: Enabling Security and Patient-centric Access Control for eHealth in cloud computing , 2011, Int. J. Secur. Networks.

[127]  Yan Hongqiao,et al.  Electronic Medical Records vs. Electronic Health Records:Yes,There Is a Difference , 2007 .

[128]  Amy J. C. Trappey,et al.  A review of essential standards and patent landscapes for the Internet of Things: A key enabler for Industry 4.0 , 2017, Adv. Eng. Informatics.

[129]  Yu-Te Wang,et al.  Pervasive brain monitoring and data sharing based on multi-tier distributed computing and linked data technology , 2014, Front. Hum. Neurosci..

[130]  Sanath S. Shenoy,et al.  Health cloud - Healthcare as a service(HaaS) , 2014, 2014 International Conference on Advances in Computing, Communications and Informatics (ICACCI).

[131]  Abbas Jamalipour,et al.  Wireless Body Area Networks: A Survey , 2014, IEEE Communications Surveys & Tutorials.

[132]  Cem Ersoy,et al.  Wireless sensor networks for healthcare: A survey , 2010, Comput. Networks.

[133]  Antonio Pescapè,et al.  The role of Information and Communication Technologies in healthcare: taxonomies, perspectives, and challenges , 2018, J. Netw. Comput. Appl..

[134]  Jun Zhang,et al.  Cloud Computing Resource Scheduling and a Survey of Its Evolutionary Approaches , 2015, ACM Comput. Surv..

[135]  Joel J. P. C. Rodrigues,et al.  Analysis of Cloud-Based Solutions on EHRs Systems in Different Scenarios , 2012, Journal of Medical Systems.

[136]  Milan Petkovic,et al.  A Home Healthcare System in the Cloud--Addressing Security and Privacy Challenges , 2011, 2011 IEEE 4th International Conference on Cloud Computing.

[137]  Kyung Sup Kwak,et al.  Medical Applications of Wireless Body Area Networks , 2009, J. Digit. Content Technol. its Appl..

[138]  Raghunath Nambiar,et al.  A look at challenges and opportunities of Big Data analytics in healthcare , 2013, 2013 IEEE International Conference on Big Data.

[139]  Joel J. P. C. Rodrigues,et al.  Biofeedback data visualization for body sensor networks , 2011, J. Netw. Comput. Appl..

[140]  Kamila Smolij,et al.  Patient health information management: searching for the right model. , 2006, Perspectives in health information management.

[141]  Antonio Pescapè,et al.  On the Network Performance of Amazon S3 Cloud-Storage Service , 2016, 2016 5th IEEE International Conference on Cloud Networking (Cloudnet).

[142]  Antonio Iera,et al.  The Internet of Things: A survey , 2010, Comput. Networks.

[143]  G. Kanagaraj,et al.  Proposal of an open-source Cloud computing system for exchanging medical images of a Hospital Information System , 2011, 3rd International Conference on Trendz in Information Sciences & Computing (TISC2011).

[144]  Phillip A. Laplante,et al.  The Internet of Things in Healthcare: Potential Applications and Challenges , 2016, IT Professional.

[145]  George Suciu,et al.  An overview of cloud middleware services for interconnection of healthcare platforms , 2014, 2014 10th International Conference on Communications (COMM).

[146]  Matthew McKnight IOT, Industry 4.0, Industrial IOT… Why connected devices are the future of design , 2017 .

[147]  Luis Rodero-Merino,et al.  Finding your Way in the Fog: Towards a Comprehensive Definition of Fog Computing , 2014, CCRV.

[148]  Ning Ye,et al.  Private and Secured Medical Data Transmission and Analysis for Wireless Sensing Healthcare System , 2017, IEEE Transactions on Industrial Informatics.

[149]  Richard Cimler,et al.  Cloud based solution for mobile healthcare application , 2014, IDEAS.

[150]  Joel J. P. C. Rodrigues,et al.  Analysis of the Cloud Computing Paradigm on Mobile Health Records Systems , 2012, 2012 Sixth International Conference on Innovative Mobile and Internet Services in Ubiquitous Computing.

[151]  Gang-hoon Kim,et al.  Potentiality of Big Data in the Medical Sector: Focus on How to Reshape the Healthcare System , 2013, Healthcare informatics research.

[152]  A. Kuo Opportunities and Challenges of Cloud Computing to Improve Health Care Services , 2011, Journal of medical Internet research.

[153]  Karin M. Verspoor,et al.  Big Data in Medicine Is Driving Big Changes , 2014, Yearbook of Medical Informatics.

[154]  Peter J. Hunter,et al.  Big Data, Big Knowledge: Big Data for Personalized Healthcare , 2015, IEEE Journal of Biomedical and Health Informatics.

[155]  Athanasios V. Vasilakos,et al.  A Survey on Ambient Intelligence in Healthcare , 2013, Proceedings of the IEEE.

[156]  Xiaopeng Zhao,et al.  Cloud-ECG for real time ECG monitoring and analysis , 2013, Comput. Methods Programs Biomed..

[157]  Yonggang Wen,et al.  Toward Scalable Systems for Big Data Analytics: A Technology Tutorial , 2014, IEEE Access.

[158]  Antonio Pescapè,et al.  On the performance of the wide-area networks interconnecting public-cloud datacenters around the globe , 2017, Comput. Networks.

[159]  Antonio Pescapè,et al.  Cloud monitoring: Definitions, issues and future directions , 2012, 2012 IEEE 1st International Conference on Cloud Networking (CLOUDNET).

[160]  Feipei Lai,et al.  A secure electronic medical record sharing mechanism in the cloud computing platform , 2011, 2011 IEEE 15th International Symposium on Consumer Electronics (ISCE).

[161]  Jean-Marie Bonnin,et al.  Wireless sensor networks: a survey on recent developments and potential synergies , 2013, The Journal of Supercomputing.

[162]  Sivanesan Dakshanamurthy,et al.  Big data: the next frontier for innovation in therapeutics and healthcare , 2014, Expert review of clinical pharmacology.

[163]  Min Chen,et al.  NDNC-BAN: Supporting rich media healthcare services via named data networking in cloud-assisted wireless body area networks , 2014, Inf. Sci..