How to quantify iron in an aqueous or biological matrix: a technical note.

Iron oxide (nano)particles are powerful contrast agents for MRI and tags for magnetic cellular labeling. The need for quantitative methods to evaluate the iron content of contrast media solutions and biological matrixes is thus obvious. Several convenient methods aiming at the quantification of iron from iron oxide nanoparticle-containing samples are presented.

[1]  S. Laurent,et al.  Magnetic labeling of non-phagocytic adherent cells with iron oxide nanoparticles: a comprehensive study. , 2008, Contrast media & molecular imaging.

[2]  R. Koncki.  Chemical Sensors and Biosensors Based on Prussian Blues , 2002 .

[3]  J. Frank,et al.  Optimization and Validation of FePro Cell Labeling Method , 2009, PloS one.

[4]  S. Laurent,et al.  Development of magnetic chromatography to sort polydisperse nanoparticles in ferrofluids. , 2010, Contrast media & molecular imaging.

[5]  Dmitri Artemov,et al.  Molecular magnetic resonance imaging with targeted contrast agents , 2003, Journal of cellular biochemistry.

[6]  Isabelle Raynal,et al.  Macrophage Endocytosis of Superparamagnetic Iron Oxide Nanoparticles: Mechanisms and Comparison of Ferumoxides and Ferumoxtran-10 , 2004, Investigative radiology.

[7]  C. Robic,et al.  Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. , 2008, Chemical reviews.

[8]  Wolfgang Ebert,et al.  Tissue-specific MR contrast agents. , 2003, European journal of radiology.

[9]  J. Riemer,et al.  Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells. , 2004, Analytical biochemistry.

[10]  S. Laurent,et al.  C-MALISA (cellular magnetic-linked immunosorbent assay), a new application of cellular ELISA for MRI. , 2005, Journal of inorganic biochemistry.

[11]  Mathias Hoehn,et al.  Cellular MR Imaging , 2005, Molecular imaging.