Protein-Translocating Trimeric Autotransporters of Gram-Negative Bacteria

Gram-negative bacteria possess a two-membrane envelope with an outer lipopolysaccharide-containing membrane that provides an effective barrier, protecting these organisms from detergents, organic solvents, drugs, and other toxic substances ([24][1]). However, the occurrence of an outer membrane

[1]  H. Mobley,et al.  Identification of Sat, an autotransporter toxin produced by uropathogenic Escherichia coli , 2000, Molecular microbiology.

[2]  M. Saier,et al.  Protein secretion systems of Pseudomonas aeruginosa and P fluorescens. , 2003, Biochimica et biophysica acta.

[3]  D. L. Cox,et al.  TP0453, a Concealed Outer Membrane Protein of Treponema pallidum, Enhances Membrane Permeability , 2005, Journal of bacteriology.

[4]  B. van den Berg,et al.  Crystal structure of the bacterial nucleoside transporter Tsx , 2004, The EMBO journal.

[5]  D. Fink,et al.  The Haemophilus influenzae Hap autotransporter mediates microcolony formation and adherence to epithelial cells and extracellular matrix via binding regions in the C‐terminal end of the passenger domain , 2003, Cellular microbiology.

[6]  J. Tommassen,et al.  In vivo expression of Neisseria meningitidis proteins homologous to the Haemophilus influenzae Hap and Hia autotransporters. , 2001, FEMS immunology and medical microbiology.

[7]  T. Rapoport,et al.  Crystal Structure of the Long-Chain Fatty Acid Transporter FadL , 2004, Science.

[8]  Wolfgang Busch,et al.  Two Families of Mechanosensitive Channel Proteins , 2003, Microbiology and Molecular Biology Reviews.

[9]  D. Fink,et al.  The C-Terminal Fragment of the Internal 110-Kilodalton Passenger Domain of the Hap Protein of Nontypeable Haemophilus influenzae Is a Potential Vaccine Candidate , 2004, Infection and Immunity.

[10]  J. Tame,et al.  Crystal Structure of Hemoglobin Protease, a Heme Binding Autotransporter Protein from Pathogenic Escherichia coli* , 2005, Journal of Biological Chemistry.

[11]  I. Henderson,et al.  Autotransporter proteins, evolution and redefining protein secretion. , 2000, Trends in microbiology.

[12]  J. M. Saier Families of Proteins Forming Transmembrane Channels , 2000, The Journal of membrane biology.

[13]  M. Skurnik,et al.  Hydrophobic domains affect the collagen‐binding specificity and surface polymerization as well as the virulence potential of the YadA protein of Yersinia enterocolitica , 1993, Molecular microbiology.

[14]  J. Thompson,et al.  The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. , 1997, Nucleic acids research.

[15]  Colin Hughes,et al.  Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export , 2000, Nature.

[16]  G. Waksman,et al.  Structural basis for host recognition by the Haemophilus influenzae Hia autotransporter , 2004, The EMBO journal.

[17]  T. Meyer,et al.  Characterization of the Essential Transport Function of the AIDA-I Autotransporter and Evidence Supporting Structural Predictions , 1999, Journal of bacteriology.

[18]  J. Eswaran,et al.  Structure and function of TolC: the bacterial exit duct for proteins and drugs. , 2004, Annual review of biochemistry.

[19]  J. Devereux,et al.  A comprehensive set of sequence analysis programs for the VAX , 1984, Nucleic Acids Res..

[20]  J. S. St. Geme,et al.  The Haemophilus influenzae Hia Autotransporter Contains an Unusually Short Trimeric Translocator Domain* , 2004, Journal of Biological Chemistry.

[21]  S. Beatson,et al.  Protein secretion systems in Fusobacterium nucleatum: genomic identification of Type 4 piliation and complete Type V pathways brings new insight into mechanisms of pathogenesis. , 2005, Biochimica et biophysica acta.

[22]  Yufeng Zhai,et al.  Protein-translocating outer membrane porins of Gram-negative bacteria. , 2002, Biochimica et biophysica acta.

[23]  M. Saier A Functional-Phylogenetic Classification System for Transmembrane Solute Transporters , 2000, Microbiology and Molecular Biology Reviews.

[24]  M. Saier,et al.  A novel family of channel-forming, autotransporting, bacterial virulence factors. , 1997, Molecular membrane biology.

[25]  J. Tommassen,et al.  Role of a Highly Conserved Bacterial Protein in Outer Membrane Protein Assembly , 2003, Science.

[26]  Mikael Skurnik,et al.  The Yersinia adhesin YadA collagen‐binding domain structure is a novel left‐handed parallel β‐roll , 2004, The EMBO journal.

[27]  I. Henderson,et al.  Virulence Functions of Autotransporter Proteins , 2001, Infection and Immunity.

[28]  J. Eswaran,et al.  Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC. , 2004, Journal of molecular biology.

[29]  Cloning and Characterization of the Gene Encoding for OMP-PD Porin: The Major Photobacterium damsela Outer Membrane Protein , 2004, Current Microbiology.

[30]  E. Hoiczyk,et al.  Structure and sequence analysis of Yersinia YadA and Moraxella UspAs reveal a novel class of adhesins , 2000, The EMBO journal.

[31]  J. S. St. Geme,et al.  The Haemophilus influenzae Hia Adhesin Is an Autotransporter Protein That Remains Uncleaved at the C Terminus and Fully Cell Associated , 2000, Journal of bacteriology.

[32]  I. Henderson,et al.  Type V Protein Secretion Pathway: the Autotransporter Story , 2004, Microbiology and Molecular Biology Reviews.

[33]  M. Skurnik,et al.  YadA, the multifaceted Yersinia adhesin. , 2001, International journal of medical microbiology : IJMM.

[34]  M. Saier,et al.  The β‐barrel finder (BBF) program, allowing identification of outer membrane β‐barrel proteins encoded within prokaryotic genomes , 2002 .

[35]  M. Biedzka-Sarek,et al.  Role of YadA, Ail and Lipopolysaccharide in Serum Resistance of Yersinia enterocolitica Serotype O:3 , 2004, Infection and Immunity.

[36]  F. Jacob-Dubuisson,et al.  Protein secretion through autotransporter and two-partner pathways. , 2004, Biochimica et biophysica acta.

[37]  Thomas L. Madden,et al.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. , 1997, Nucleic acids research.

[38]  B. Dijkstra,et al.  Unusual catalytic triad of Escherichia coli outer membrane phospholipase A. , 2000, Biochemistry.

[39]  H. Schweizer,et al.  Bacterial resistance to antibiotics: active efflux and reduced uptake. , 2005, Advanced drug delivery reviews.

[40]  M H Saier,et al.  A web-based program for the prediction of average hydropathy, average amphipathicity and average similarity of multiply aligned homologous proteins. , 2001, Journal of molecular microbiology and biotechnology.

[41]  J. S. St. Geme,et al.  The Haemophilus influenzae Hia autotransporter harbours two adhesive pockets that reside in the passenger domain and recognize the same host cell receptor , 2002, Molecular microbiology.

[42]  Milton H Saier,et al.  Tracing pathways of transport protein evolution , 2003, Molecular microbiology.

[43]  Piet Gros,et al.  Structure of the translocator domain of a bacterial autotransporter , 2004, The EMBO journal.

[44]  Yufeng Zhai,et al.  A web-based Tree View (TV) program for the visualization of phylogenetic trees. , 2002, Journal of molecular microbiology and biotechnology.

[45]  W. Kühlbrandt,et al.  Atomic model of the E. coli membrane-bound protein translocation complex SecYEG. , 2005, Journal of molecular biology.

[46]  M. Saier,et al.  The Transporter Classification (TC) System, 2002 , 2002, Critical reviews in biochemistry and molecular biology.

[47]  G. Schulz,et al.  High-resolution structure of the OmpA membrane domain. , 2000, Journal of molecular biology.

[48]  K. H. Kalk,et al.  Structural evidence for dimerization-regulated activation of an integral membrane phospholipase , 1999, Nature.

[49]  J. S. St. Geme,et al.  Architecture and Adhesive Activity of the Haemophilus influenzae Hsf Adhesin , 2005, Journal of bacteriology.

[50]  J. Heesemann,et al.  Molecular Analysis of Transport and Oligomerization of the Yersinia enterocolitica Adhesin YadA , 2003, Journal of bacteriology.

[51]  Milton H. Saier,et al.  Answering Fundamental Questions in Biology with Bioinformatics Although biological advances depend on experiments, emerging theory-based disciplines also expand our understanding of life and its origins , 2003 .

[52]  J. S. St. Geme,et al.  Trimeric autotransporters: a distinct subfamily of autotransporter proteins. , 2005, Trends in microbiology.

[53]  B. Dijkstra,et al.  Bacterial phospholipase A: structure and function of an integral membrane phospholipase. , 2000, Biochimica et biophysica acta.

[54]  C. Stathopoulos,et al.  Autotransporter and Two-Partner Secretion: Delivery of Large-Size Virulence Factors by Gram-Negative Bacterial Pathogens , 2004, Critical reviews in microbiology.

[55]  D. Fink,et al.  Chromosomal Expression of the Haemophilus influenzae Hap Autotransporter Allows Fine-Tuned Regulation of Adhesive Potential via Inhibition of Intermolecular Autoproteolysis , 2003, Journal of bacteriology.