Paediatric and adult-onset male hypogonadism

[1]  F. Cosentino,et al.  The 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. , 2019, European heart journal.

[2]  J. Kaufman,et al.  Aging and the Male Reproductive System. , 2019, Endocrine reviews.

[3]  S. Burgess,et al.  Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank , 2019, BMJ.

[4]  H. Huopio,et al.  Letrozole versus testosterone for promotion of endogenous puberty in boys with constitutional delay of growth and puberty: a randomised controlled phase 3 trial. , 2019, The Lancet. Child & adolescent health.

[5]  C. Lewis,et al.  Effect of testosterone replacement on measures of mobility in older men with mobility limitation and low testosterone concentrations: secondary analyses of the Testosterone Trials. , 2018, The lancet. Diabetes & endocrinology.

[6]  L. Dunkel,et al.  Delayed puberty , 2018, Rapid Paediatrics and Child Health.

[7]  R. Rey,et al.  Male Central Hypogonadism in Paediatrics – the Relevance of Follicle-stimulating Hormone and Sertoli Cell Markers , 2018, European endocrinology.

[8]  H. Kuang,et al.  Short‐term combined treatment with exenatide and metformin is superior to glimepiride combined metformin in improvement of serum testosterone levels in type 2 diabetic patients with obesity , 2018, Andrologia.

[9]  E. Nieschlag,et al.  Klinefelter syndrome: more than hypogonadism. , 2018, Metabolism: clinical and experimental.

[10]  E. Mannucci,et al.  Endogenous Testosterone Levels and Cardiovascular Risk: Meta-Analysis of Observational Studies. , 2018, The journal of sexual medicine.

[11]  M. Wallentin,et al.  Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology. , 2018, Endocrine reviews.

[12]  E. Platz,et al.  Evaluation and Management of Testosterone Deficiency: AUA Guideline , 2018, The Journal of urology.

[13]  N. Pendleton,et al.  Symptomatic androgen deficiency develops only when both total and free testosterone decline in obese men who may have incident biochemical secondary hypogonadism: Prospective results from the EMAS , 2018, Clinical endocrinology.

[14]  J. Goodwin,et al.  Testosterone Prescribing in the United States, 2002-2016 , 2018, JAMA.

[15]  Guihua Liu,et al.  Hypothalamic endoplasmic reticulum stress as a key mediator of obesity‐induced leptin resistance , 2018, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[16]  E. Mannucci,et al.  Testosterone and Cardiovascular Risk: Meta-Analysis of Interventional Studies. , 2018, The journal of sexual medicine.

[17]  S. Bhasin,et al.  The Efficacy and Adverse Events of Testosterone Replacement Therapy in Hypogonadal Men: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials , 2018, The Journal of clinical endocrinology and metabolism.

[18]  Frederick C W Wu,et al.  Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. , 2018, The Journal of clinical endocrinology and metabolism.

[19]  S. Seminara,et al.  Divergent responses to kisspeptin in children with delayed puberty. , 2018, JCI insight.

[20]  E. Mannucci,et al.  Sex hormone‐binding globulin is associated with androgen deficiency features independently of total testosterone , 2018, Clinical endocrinology.

[21]  D. Vanderschueren,et al.  EAA clinical guideline on management of bone health in the andrological outpatient clinic , 2018, Andrology.

[22]  M. Schierup,et al.  Transcriptome profiling of fetal Klinefelter testis tissue reveals a possible involvement of long non-coding RNAs in gonocyte maturation , 2018, Human molecular genetics.

[23]  M. Cappa,et al.  Use of testosterone gel compared to intramuscular formulation for puberty induction in males with constitutional delay of growth and puberty: a preliminary study , 2018, Journal of Endocrinological Investigation.

[24]  J. Bilezikian,et al.  New and developing pharmacotherapy for osteoporosis in men , 2018, Expert opinion on pharmacotherapy.

[25]  M. Maggi,et al.  The safety of available treatments of male hypogonadism in organic and functional hypogonadism , 2018, Expert opinion on drug safety.

[26]  M. Rutter,et al.  Elevated luteinizing hormone despite normal testosterone levels in older men—natural history, risk factors and clinical features , 2017, Clinical endocrinology.

[27]  G. Hackett,et al.  British Society for Sexual Medicine Guidelines on Adult Testosterone Deficiency, With Statements for UK Practice. , 2017, The journal of sexual medicine.

[28]  E. Mannucci,et al.  Meta-analysis of Results of Testosterone Therapy on Sexual Function Based on International Index of Erectile Function Scores. , 2017, European urology.

[29]  F. Montorsi,et al.  Does Calculated Free Testosterone Overcome Total Testosterone in Protecting From Sexual Symptom Impairment? Findings of a Cross-Sectional Study. , 2017, The journal of sexual medicine.

[30]  G. Giurato,et al.  Decreased miRNA expression in Klinefelter syndrome , 2017, Scientific Reports.

[31]  M. Rutter,et al.  Reproductive Hormone Levels Predict Changes in Frailty Status in Community-Dwelling Older Men: European Male Ageing Study Prospective Data , 2017, The Journal of clinical endocrinology and metabolism.

[32]  B. Zirkin,et al.  Steroidogenesis in Leydig cells: effects of aging and environmental factors. , 2017, Reproduction.

[33]  R. Hoermann,et al.  The effects of testosterone on body composition in obese men are not sustained after cessation of testosterone treatment , 2017, Clinical endocrinology.

[34]  S. Maeda,et al.  Vigorous Physical Activity is Associated with Regular Aerobic Exercise-Induced Increased Serum Testosterone Levels in Overweight/Obese Men , 2017, Hormone and Metabolic Research.

[35]  A. Bianchi,et al.  DIAGNOSIS OF ENDOCRINE DISEASE: Primary empty sella: a comprehensive review. , 2017, European journal of endocrinology.

[36]  Frederick C W Wu,et al.  A Reappraisal of Testosterone's Binding in Circulation: Physiological and Clinical Implications. , 2017, Endocrine reviews.

[37]  Clara P. Savage,et al.  Subcutaneous Injection of Testosterone Is an Effective and Preferred Alternative to Intramuscular Injection: Demonstration in Female-to-Male Transgender Patients , 2017, The Journal of clinical endocrinology and metabolism.

[38]  A. Lenzi,et al.  Sperm recovery and ICSI outcomes in Klinefelter syndrome: a systematic review and meta-analysis , 2017, Human reproduction update.

[39]  F. Piel,et al.  Sickle Cell Disease. , 2017, The New England journal of medicine.

[40]  C. Lewis,et al.  Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone: A Controlled Clinical Trial , 2017, JAMA internal medicine.

[41]  Maristella,et al.  Genomic analyses identify hundreds of variants associated with age at menarche and 1 support a role for puberty timing in cancer risk 2 , 2017 .

[42]  H. Cohen,et al.  Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial , 2017, JAMA internal medicine.

[43]  T. Travison,et al.  Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe , 2017, The Journal of clinical endocrinology and metabolism.

[44]  O. Trubiani,et al.  Testis Transcriptome Modulation in Klinefelter Patients with Hypospermatogenesis , 2017, Scientific Reports.

[45]  M. Mohammadi,et al.  Genetic testing facilitates prepubertal diagnosis of congenital hypogonadotropic hypogonadism , 2017, Clinical genetics.

[46]  S. Senniappan,et al.  Testosterone Therapy Improves the First Year Height Velocity in Adolescent Boys with Constitutional Delay of Growth and Puberty , 2017, International journal of endocrinology and metabolism.

[47]  S. Resnick,et al.  Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment , 2017, JAMA.

[48]  M. Molitch Diagnosis and Treatment of Pituitary Adenomas: A Review , 2017, JAMA.

[49]  A. Matsumoto,et al.  A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management , 2017, The Journal of clinical endocrinology and metabolism.

[50]  M. Polak,et al.  Efficacy and Safety of Continuous Subcutaneous Infusion of Recombinant Human Gonadotropins for Congenital Micropenis during Early Infancy
 , 2017, Hormone Research in Paediatrics.

[51]  M. Zacharin,et al.  Testicular growth and spermatogenesis: new goals for pubertal hormone replacement in boys with hypogonadotropic hypogonadism? ‐a multicentre prospective study of hCG/rFSH treatment outcomes during adolescence‐ , 2017, Clinical endocrinology.

[52]  N. Santoro,et al.  Acute Recapitulation of the Hyperinsulinemia and Hyperlipidemia characteristic of Metabolic Syndrome suppresses Gonadotropins , 2016, Obesity.

[53]  T. Raivio,et al.  Congenital hypogonadotropic hypogonadism, functional hypogonadotropism or constitutional delay of growth and puberty? An analysis of a large patient series from a single tertiary center , 2016, Human reproduction.

[54]  A. Salonia,et al.  Diagnosis and Treatment of Testosterone Deficiency: Recommendations From the Fourth International Consultation for Sexual Medicine (ICSM 2015). , 2016, The journal of sexual medicine.

[55]  S. Cen,et al.  Risk factors associated with the surgical management of craniopharyngiomas in pediatric patients: analysis of 1961 patients from a national registry database. , 2016, Neurosurgical focus.

[56]  A. Traish,et al.  Testosterone Deficiency and Testosterone Treatment in Older Men , 2016, Gerontology.

[57]  Philip S Li,et al.  Spermatogenesis in humans and its affecting factors. , 2016, Seminars in cell & developmental biology.

[58]  N. Cole,et al.  Testosterone undecanoate improves sexual function in men with type 2 diabetes and severe hypogonadism: results from a 30‐week randomized placebo‐controlled study , 2016, BJU international.

[59]  G. Tirabassi,et al.  Klinefelter syndrome (KS): genetics, clinical phenotype and hypogonadism , 2016, Journal of Endocrinological Investigation.

[60]  S. Brunak,et al.  Klinefelter syndrome comorbidities linked to increased X chromosome gene dosage and altered protein interactome activity , 2017, Human molecular genetics.

[61]  J. Morley,et al.  Testosterone therapy, association with age, initiation and mode of therapy with cardiovascular events: a systematic review , 2016, Clinical endocrinology.

[62]  H. Burger,et al.  Endocrine Society of Australia position statement on male hypogonadism (part 1): assessment and indications for testosterone therapy , 2016, The Medical journal of Australia.

[63]  C. Niederberger,et al.  Diagnosis and treatment of infertility-related male hormonal dysfunction , 2016, Nature Reviews Urology.

[64]  A. Delmas,et al.  A synthetic kisspeptin analog that triggers ovulation and advances puberty , 2016, Scientific Reports.

[65]  J. Butler,et al.  Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty. , 2016, The Journal of clinical endocrinology and metabolism.

[66]  M. Palmert,et al.  Evaluation of delayed puberty: what diagnostic tests should be performed in the seemingly otherwise well adolescent? , 2016, Archives of Disease in Childhood.

[67]  A. Aversa,et al.  Testosterone supplementation and body composition: results from a meta-analysis of observational studies , 2016, Journal of Endocrinological Investigation.

[68]  R. Corradi,et al.  Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male. , 2016, The Urologic clinics of North America.

[69]  S. Bhasin,et al.  Hypogonadism: Its Prevalence and Diagnosis. , 2016, The Urologic clinics of North America.

[70]  Sonal Singh,et al.  Cardiovascular Risks of Exogenous Testosterone Use Among Men: A Systematic Review and Meta-Analysis. , 2016, The American journal of medicine.

[71]  A. Salonia,et al.  Pharmacotherapy for Erectile Dysfunction: Recommendations From the Fourth International Consultation for Sexual Medicine (ICSM 2015). , 2016, The journal of sexual medicine.

[72]  L. Cohen,et al.  Sperm Retrieval in Adolescents and Young Adults with Klinefelter Syndrome: A Prospective, Pilot Study. , 2016, The Journal of pediatrics.

[73]  R. Hayes,et al.  Effect of Testosterone Solution 2% on Testosterone Concentration, Sex Drive and Energy in Hypogonadal Men: Results of a Placebo Controlled Study. , 2016, The Journal of urology.

[74]  A. Aversa,et al.  THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: results from a meta-analysis study. , 2016, European journal of endocrinology.

[75]  F. Blyth,et al.  Temporal Trend in Androgen Status and Androgen-Sensitive Outcomes in Older Men. , 2016, The Journal of clinical endocrinology and metabolism.

[76]  S. Resnick,et al.  Effects of Testosterone Treatment in Older Men. , 2016, The New England journal of medicine.

[77]  P. Takahashi,et al.  Proinflammatory Cytokine Infusion Attenuates LH's Feedforward on Testosterone Secretion: Modulation by Age. , 2016, The Journal of clinical endocrinology and metabolism.

[78]  W. Crowley,et al.  Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. , 2016, Endocrine reviews.

[79]  Eric Vilain,et al.  Global Disorders of Sex Development Update since 2006: Perceptions, Approach and Care , 2016, Hormone Research in Paediatrics.

[80]  A. Rogol,et al.  Natesto™, a novel testosterone nasal gel, normalizes androgen levels in hypogonadal men , 2016, Andrology.

[81]  E. Mannucci,et al.  Obesity and late-onset hypogonadism , 2015, Molecular and Cellular Endocrinology.

[82]  G. Guyatt,et al.  Diagnosis and management of testosterone deficiency syndrome in men: clinical practice guideline , 2015, Canadian Medical Association Journal.

[83]  Y. Kuo,et al.  Long-term Exposure to Testosterone Therapy and the Risk of High Grade Prostate Cancer. , 2015, The Journal of urology.

[84]  I. Vogel,et al.  Induction of puberty with human chorionic gonadotropin (hCG) followed by reversal of hypogonadotropic hypogonadism in Kallmann syndrome. , 2015, Endokrynologia Polska.

[85]  C. Tsatsanis,et al.  The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis , 2015, Hormones.

[86]  F. Casanueva,et al.  Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone levels: results from the European Male Ageing Study , 2015, Archives of Public Health.

[87]  E. Crowne,et al.  Recent advances in the understanding and management of delayed puberty , 2015, Archives of Disease in Childhood.

[88]  A. Seftel Re: Testosterone Products: Drug Safety Communication - FDA Cautions about Using Testosterone Products for Low Testosterone due to Aging; Requires Labeling Change to Inform of Possible Increased Risk of Heart Attack and Stroke. , 2015, The Journal of urology.

[89]  D. Berlowitz,et al.  Ascertainment of Testosterone Prescribing Practices in the VA , 2015, Medical care.

[90]  M. Maghnie,et al.  Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment , 2015, Nature Reviews Endocrinology.

[91]  T. Travison,et al.  Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels: A Randomized Clinical Trial. , 2015, JAMA.

[92]  B. Keevil,et al.  Mass spectrometry and immunoassay: how to measure steroid hormones today and tomorrow. , 2015, European journal of endocrinology.

[93]  A. Gropman,et al.  Positive effects of early androgen therapy on the behavioral phenotype of boys with 47,XXY , 2015, American journal of medical genetics. Part C, Seminars in medical genetics.

[94]  N. Pendleton,et al.  Development of and Recovery from Secondary Hypogonadism in Aging Men: Prospective Results from the EMAS. , 2015, The Journal of clinical endocrinology and metabolism.

[95]  Di Wu,et al.  Pulsatile GnRH Is Superior to hCG in Therapeutic Efficacy in Adolescent Boys With Hypogonadotropic Hypogonadodism. , 2015, The Journal of clinical endocrinology and metabolism.

[96]  T. Beaty,et al.  Genome‐wide site‐specific differential methylation in the blood of individuals with Klinefelter syndrome , 2015, Molecular reproduction and development.

[97]  G. Forti,et al.  Prevalence of endocrine and metabolic disorders in subjects with erectile dysfunction: a comparative study. , 2015, The journal of sexual medicine.

[98]  Michael H. Guo,et al.  A shared genetic basis for self-limited delayed puberty and idiopathic hypogonadotropic hypogonadism. , 2015, The Journal of clinical endocrinology and metabolism.

[99]  M. Maggi,et al.  The pharmacotherapy of male hypogonadism besides androgens , 2015, Expert opinion on pharmacotherapy.

[100]  J. Petersen,et al.  Evaluation of 451 Danish boys with delayed puberty: diagnostic use of a new puberty nomogram and effects of oral testosterone therapy. , 2015, The Journal of clinical endocrinology and metabolism.

[101]  S. Arver,et al.  Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men , 2015, The aging male : the official journal of the International Society for the Study of the Aging Male.

[102]  B. Carleton,et al.  Testosterone Therapy and Risk of Myocardial Infarction: A Pharmacoepidemiologic Study , 2015, Pharmacotherapy.

[103]  J. Shuster,et al.  Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: a systematic review and meta-analysis , 2014, BMC Medicine.

[104]  E. Mannucci,et al.  Factors affecting spermatogenesis upon gonadotropin‐replacement therapy: a meta‐analytic study , 2014, Andrology.

[105]  B. Yeap Hormonal changes and their impact on cognition and mental health of ageing men. , 2014, Maturitas.

[106]  A. Isidori,et al.  Cardiovascular risk associated with testosterone-boosting medications: a systematic review and meta-analysis , 2014, Expert opinion on drug safety.

[107]  R. Quinton,et al.  Reversal of isolated hypogonadotropic hypogonadism: long‐term integrity of hypothalamo–pituitary–testicular axis in two men is dependent on intermittent androgen exposure , 2014, Clinical endocrinology.

[108]  F. Sweep,et al.  Gonadal status and outcome of bariatric surgery in obese men , 2014, Clinical endocrinology.

[109]  Andrew D. Johnson,et al.  Parent-of-Origin Specific Allelic Associations Among 106 Genomic Loci for Age at Menarche , 2014 .

[110]  L. Dunkel,et al.  Activation of the Hypothalamic-Pituitary-Gonadal Axis in Infancy: Minipuberty , 2014, Hormone Research in Paediatrics.

[111]  R. Quinton,et al.  Transition in endocrinology: induction of puberty. , 2014, European journal of endocrinology.

[112]  T. Travison,et al.  Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point. , 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

[113]  A. Lenzi,et al.  Testosterone supplementation and sexual function: a meta-analysis study. , 2014, The journal of sexual medicine.

[114]  P. Schnohr,et al.  Endogenous sex hormones and risk of venous thromboembolism in women and men , 2014, Journal of thrombosis and haemostasis : JTH.

[115]  N. Cole,et al.  Testosterone replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: the BLAST study. , 2014, The journal of sexual medicine.

[116]  R. Quinton,et al.  Reversal and relapse of hypogonadotropic hypogonadism: resilience and fragility of the reproductive neuroendocrine system. , 2014, The Journal of clinical endocrinology and metabolism.

[117]  R. Rey,et al.  Spreading the Clinical Window for Diagnosing Fetal-Onset Hypogonadism in Boys , 2014, Front. Endocrinol..

[118]  I. Huhtaniemi Late-onset hypogonadism: Current concepts and controversies of pathogenesis, diagnosis and treatment , 2014, Asian journal of andrology.

[119]  R. Rey,et al.  Male Central Precocious Puberty: Serum Profile of Anti-Müllerian Hormone and Inhibin B before, during, and after Treatment with GnRH Analogue , 2013, International journal of endocrinology.

[120]  M. Tena-Sempere Interaction Between Energy Homeostasis and Reproduction: Central Effects of Leptin and Ghrelin on the Reproductive Axis , 2013, Hormone and Metabolic Research.

[121]  K. Berger,et al.  The relation between sex hormone levels, the androgen receptor CAGn-polymorphism and depression and mortality in older men in a community study , 2013, Psychoneuroendocrinology.

[122]  O. Rouaud,et al.  A J-shaped association between plasma testosterone and risk of ischemic arterial event in elderly men: the French 3C cohort study. , 2013, Maturitas.

[123]  A. Araujo,et al.  Longitudinal changes in testosterone over five years in community-dwelling men. , 2013, The Journal of clinical endocrinology and metabolism.

[124]  G. Forti,et al.  Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis. , 2013, European journal of endocrinology.

[125]  B. Cowling,et al.  Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials , 2013, BMC Medicine.

[126]  A. Juul,et al.  Testicular function and fertility in men with Klinefelter syndrome: a review. , 2013, European journal of endocrinology.

[127]  Luc J. Martin,et al.  Implications of leptin in neuroendocrine regulation of male reproduction. , 2013, Reproductive biology.

[128]  S. Boonen,et al.  Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study. , 2013, European journal of endocrinology.

[129]  N. Jørgensen,et al.  47,XXY Klinefelter syndrome: Clinical characteristics and age‐specific recommendations for medical management , 2013, American journal of medical genetics. Part C, Seminars in medical genetics.

[130]  R. Rey,et al.  Male hypogonadism: an extended classification based on a developmental, endocrine physiology‐based approach , 2013, Andrology.

[131]  K. Main,et al.  The pubertal transition in 179 healthy Danish children: associations between pubarche, adrenarche, gonadarche, and body composition. , 2012, European journal of endocrinology.

[132]  C. Hoyos,et al.  Effects of testosterone therapy on sleep and breathing in obese men with severe obstructive sleep apnoea: a randomized placebo‐controlled trial , 2012, Clinical endocrinology.

[133]  M. Puig-Domingo,et al.  Hypogonadotropic Hypogonadism in Morbidly Obese Males Is Reversed After Bariatric Surgery , 2012, Obesity Surgery.

[134]  M. Kupczyk,et al.  US and European severe asthma cohorts: what can they teach us about severe asthma? , 2012, Journal of internal medicine.

[135]  M. Palmert,et al.  Clinical review: Distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism: critical appraisal of available diagnostic tests. , 2012, The Journal of clinical endocrinology and metabolism.

[136]  J. Toppari,et al.  Reversible Congenital Hypogonadotropic Hypogonadism in Patients with CHD7, FGFR1 or GNRHR Mutations , 2012, PloS one.

[137]  L. Vignozzi,et al.  Emerging medication for the treatment of male hypogonadism , 2012, Expert opinion on emerging drugs.

[138]  R. Rey,et al.  Gonadotrophin secretion pattern in anorchid boys from birth to pubertal age: pathophysiological aspects and diagnostic usefulness , 2012, Clinical endocrinology.

[139]  C Barbui,et al.  What is the European Medicines Agency? , 2012, Epidemiology and Psychiatric Sciences.

[140]  L. Dunkel,et al.  Testosterone measured in infancy predicts subsequent sex-typed behavior in boys and in girls , 2012, Hormones and Behavior.

[141]  S. B. Nunez,et al.  Aromatase inhibitors in pediatrics , 2012, Nature Reviews Endocrinology.

[142]  Jacques Young,et al.  Neonatal gonadotropin therapy in male congenital hypogonadotropic hypogonadism , 2012, Nature Reviews Endocrinology.

[143]  A. Topaloğlu,et al.  Inactivating KISS1 mutation and hypogonadotropic hypogonadism. , 2012, The New England journal of medicine.

[144]  M. Miner,et al.  The effect of testosterone supplementation on depression symptoms in hypogonadal men from the Testim Registry in the US (TRiUS) , 2012, The aging male : the official journal of the International Society for the Study of the Aging Male.

[145]  W. Crowley,et al.  Genetic counseling for isolated GnRH deficiency , 2011, Molecular and Cellular Endocrinology.

[146]  R. Rey,et al.  Early onset of primary hypogonadism revealed by serum anti-Müllerian hormone determination during infancy and childhood in trisomy 21. , 2011, International journal of andrology.

[147]  W. Miller,et al.  Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation. , 2011, American journal of human genetics.

[148]  R. Ivell,et al.  Biological role and clinical significance of insulin-like peptide 3 , 2011, Current opinion in endocrinology, diabetes, and obesity.

[149]  M. Lishner,et al.  Fertility considerations and preservation in haemato‐oncology patients undergoing treatment , 2011, British journal of haematology.

[150]  Philippe Seksik,et al.  Epidemiology and natural history of inflammatory bowel diseases. , 2011, Gastroenterology.

[151]  R. Rey,et al.  Normal male sexual differentiation and aetiology of disorders of sex development. , 2011, Best practice & research. Clinical endocrinology & metabolism.

[152]  S. Arver,et al.  Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndrome (the TIMES2 Study) , 2011, Diabetes Care.

[153]  G. Schneider,et al.  Depressive symptoms in men aged 50 years and older and their relationship to genetic androgen receptor polymorphism and sex hormone levels in three different samples. , 2011, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[154]  S. Grebe,et al.  Accuracy of calculated free testosterone differs between equations and depends on gender and SHBG concentration , 2011, Steroids.

[155]  A. Griffiths,et al.  Epidemiology of pediatric inflammatory bowel disease: A systematic review of international trends , 2011, Inflammatory bowel diseases.

[156]  C. Bouvattier,et al.  Baseline inhibin B and anti-Mullerian hormone measurements for diagnosis of hypogonadotropic hypogonadism (HH) in boys with delayed puberty. , 2010, The Journal of clinical endocrinology and metabolism.

[157]  R. Feinn,et al.  Dehydroepiandrosterone Combined with Exercise Improves Muscle Strength and Physical Function in Frail Older Women , 2010, Journal of the American Geriatrics Society.

[158]  S. Seminara,et al.  Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus. , 2010, Endocrinology.

[159]  G. Forti,et al.  Klinefelter’s Syndrome: A Clinical and Therapeutical Update , 2010, Sexual Development.

[160]  A. Silman,et al.  Identification of late-onset hypogonadism in middle-aged and elderly men. , 2010, The New England journal of medicine.

[161]  Amy T. Wang,et al.  Clinical review 1: Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis. , 2010, The Journal of clinical endocrinology and metabolism.

[162]  J. George,et al.  Hypothesis: Kisspeptin Mediates Male Hypogonadism in Obesity and Type 2 Diabetes , 2010, Neuroendocrinology.

[163]  G. Forti,et al.  Clinical and therapeutic aspects of Klinefelter's syndrome: sexual function. , 2010, Molecular human reproduction.

[164]  R. Rey,et al.  Basal follicle-stimulating hormone and peak gonadotropin levels after gonadotropin-releasing hormone infusion show high diagnostic accuracy in boys with suspicion of hypogonadotropic hypogonadism. , 2010, The Journal of clinical endocrinology and metabolism.

[165]  V. Montori,et al.  Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. , 2010, The Journal of clinical endocrinology and metabolism.

[166]  R. Quinton,et al.  TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. , 2010, The Journal of clinical endocrinology and metabolism.

[167]  W. Crowley,et al.  Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes. , 2010, The Journal of clinical endocrinology and metabolism.

[168]  A. Silman,et al.  Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study. , 2010, The Journal of clinical endocrinology and metabolism.

[169]  R. Rey,et al.  Anti-Müllerian Hormone and Sertoli Cell Function in Paediatric Male Hypogonadism , 2010, Hormone Research in Paediatrics.

[170]  J. Fernández-Real,et al.  Adipocytokines and Insulin Resistance , 2009, Diabetes Care.

[171]  G. Balercia,et al.  Sexual dysfunction in subjects with Klinefelter's syndrome. , 2009, International journal of andrology.

[172]  I. Huhtaniemi,et al.  Aging of the human ovary and testis , 2009, Molecular and Cellular Endocrinology.

[173]  J. Donadieu,et al.  Descriptive epidemiology of childhood Langerhans cell histiocytosis in France, 2000–2004 , 2008, Pediatric blood & cancer.

[174]  A. Silman,et al.  Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. , 2008, The Journal of clinical endocrinology and metabolism.

[175]  D. Shulman,et al.  Use of Aromatase Inhibitors in Children and Adolescents With Disorders of Growth and Adolescent Development , 2008, Pediatrics.

[176]  T. Jones,et al.  Testosterone for the aging male; current evidence and recommended practice , 2008, Clinical interventions in aging.

[177]  S. Bhasin,et al.  Effects of graded doses of testosterone on erythropoiesis in healthy young and older men. , 2008, The Journal of clinical endocrinology and metabolism.

[178]  G. Forti,et al.  Why can patients with erectile dysfunction be considered lucky? The association with testosterone deficiency and metabolic syndrome , 2008, The aging male : the official journal of the International Society for the Study of the Aging Male.

[179]  L. Coolen,et al.  Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. , 2007, Endocrinology.

[180]  R. Rey,et al.  Establishment of testicular endocrine function impairment during childhood and puberty in boys with Klinefelter syndrome , 2007, Clinical endocrinology.

[181]  P. Cohen-Kettenis,et al.  Consequences of the ESPE/LWPES guidelines for diagnosis and treatment of disorders of sex development. , 2007, Best practice & research. Clinical endocrinology & metabolism.

[182]  R. Quinton,et al.  Reversal of idiopathic hypogonadotropic hypogonadism. , 2007, The New England journal of medicine.

[183]  N. Soussi-Yanicostas,et al.  FGFR1 and anosmin-1 underlying genetically distinct forms of Kallmann syndrome are co-expressed and interact in olfactory bulbs , 2007, Development Genes and Evolution.

[184]  R. Rey,et al.  Time course of the serum gonadotropin surge, inhibins, and anti-Müllerian hormone in normal newborn males during the first month of life. , 2006, The Journal of clinical endocrinology and metabolism.

[185]  U. Thyen,et al.  Epidemiology and Initial Management of Ambiguous Genitalia at Birth in Germany , 2006, Hormone Research in Paediatrics.

[186]  V. Montori,et al.  Testosterone use in men and its effects on bone health. A systematic review and meta-analysis of randomized placebo-controlled trials. , 2006, The Journal of clinical endocrinology and metabolism.

[187]  D. Chopin,et al.  Serum bioavailable testosterone: assayed or calculated? , 2006, Clinical chemistry.

[188]  D. Cota,et al.  The emerging role of the endocannabinoid system in endocrine regulation and energy balance. , 2006, Endocrine reviews.

[189]  Martin L. Lee,et al.  Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[190]  A. Lenzi,et al.  Effects of testosterone on sexual function in men: results of a meta‐analysis , 2005, Clinical endocrinology.

[191]  M. Palmert,et al.  Regulation and disorders of pubertal timing. , 2005, Endocrinology and metabolism clinics of North America.

[192]  D. Porte,et al.  Insulin signaling in the central nervous system: a critical role in metabolic homeostasis and disease from C. elegans to humans. , 2005, Diabetes.

[193]  W. Crowley,et al.  Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene. , 2005, The Journal of clinical endocrinology and metabolism.

[194]  P. Chanson,et al.  Diagnosis and treatment of pituitary adenomas. , 2004, Minerva endocrinologica.

[195]  R. Rey,et al.  Subcellular and molecular mechanisms regulating anti-Müllerian hormone gene expression in mammalian and nonmammalian species. , 2004, DNA and cell biology.

[196]  T. Klonisch,et al.  Molecular and genetic regulation of testis descent and external genitalia development. , 2004, Developmental biology.

[197]  S. M. Robinson,et al.  Triglycerides induce leptin resistance at the blood-brain barrier. , 2004, Diabetes.

[198]  A. Greenberg,et al.  Adipocytokines and insulin resistance. , 2004, The Journal of clinical endocrinology and metabolism.

[199]  R. Weber,et al.  Androgens and male fertility , 2003, World Journal of Urology.

[200]  L. Levine,et al.  The value of pituitary magnetic resonance imaging in men with hypogonadism. , 2003, The Journal of urology.

[201]  F. Speleman,et al.  Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome , 2003, Nature Genetics.

[202]  C. Gravholt,et al.  Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study. , 2003, The Journal of clinical endocrinology and metabolism.

[203]  S. Petak,et al.  American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients--2002 update. , 2002, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[204]  M. Palmert,et al.  Delayed puberty: analysis of a large case series from an academic center. , 2002, The Journal of clinical endocrinology and metabolism.

[205]  L. Ghizzoni,et al.  Delayed puberty. , 2002, Best practice & research. Clinical endocrinology & metabolism.

[206]  A. Araujo,et al.  Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. , 2002, The Journal of clinical endocrinology and metabolism.

[207]  N. Skakkebæk,et al.  Serum inhibin B levels during male childhood and puberty , 2001, Molecular and Cellular Endocrinology.

[208]  W. Crowley,et al.  The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor. , 2001, The Journal of clinical endocrinology and metabolism.

[209]  E. Metter,et al.  Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. , 2001, The Journal of clinical endocrinology and metabolism.

[210]  Rüdiger Klein,et al.  Role of Brain Insulin Receptor in Control of Body Weight and Reproduction , 2000 .

[211]  A. Isidori,et al.  Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. , 1999, The Journal of clinical endocrinology and metabolism.

[212]  A. Vermeulen,et al.  A critical evaluation of simple methods for the estimation of free testosterone in serum. , 1999, The Journal of clinical endocrinology and metabolism.

[213]  J. Berlin,et al.  Effect of testosterone treatment on bone mineral density in men over 65 years of age. , 1999, The Journal of clinical endocrinology and metabolism.

[214]  R. Huupponen,et al.  Inverse correlation between serum testosterone and leptin in men. , 1998, The Journal of clinical endocrinology and metabolism.

[215]  L. Holmes,et al.  The genetic and clinical heterogeneity of gonadotropin-releasing hormone deficiency in the human. , 1996, The Journal of clinical endocrinology and metabolism.

[216]  E. Maestrini,et al.  A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules , 1991, Nature.

[217]  D. Schoenfeld,et al.  Pulsatile gonadotropin secretion after discontinuation of long term gonadotropin-releasing hormone (GnRH) administration in a subset of GnRH-deficient men. , 1989, The Journal of clinical endocrinology and metabolism.

[218]  R. Richman,et al.  Testosterone treatment in adolescent boys with constitutional delay in growth and development. , 1988, The New England journal of medicine.

[219]  R. Scully,et al.  The spectrum of abnormal patterns of gonadotropin-releasing hormone secretion in men with idiopathic hypogonadotropic hypogonadism: clinical and laboratory correlations. , 1987, The Journal of clinical endocrinology and metabolism.

[220]  L. Johnson,et al.  Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. , 1984, The Journal of clinical endocrinology and metabolism.

[221]  G. Bray,et al.  Low serum testosterone and sex-hormone-binding-globulin in massively obese men. , 1977, The Journal of clinical endocrinology and metabolism.

[222]  J M Tanner,et al.  Variations in the Pattern of Pubertal Changes in Boys , 1970, Archives of disease in childhood.

[223]  J M Tanner,et al.  Variations in pattern of pubertal changes in girls. , 1969, Archives of disease in childhood.

[224]  A. Walther,et al.  Association of Testosterone Treatment With Alleviation of Depressive Symptoms in Men: A Systematic Review and Meta-analysis , 2019, JAMA psychiatry.

[225]  M. Maghnie,et al.  Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH). , 2018, European journal of endocrinology.

[226]  T. K. Jensen,et al.  Individual testosterone decline and future mortality risk in men. , 2018, European journal of endocrinology.

[227]  I. Huhtaniemi,et al.  Endocrinology of the Testis and Male Reproduction , 2017, Endocrinology.

[228]  L. Dunkel,et al.  Sex Steroid and Gonadotropin Treatment in Male Delayed Puberty. , 2016, Endocrine development.

[229]  L. Vignozzi,et al.  Different Medications for Hypogonadotropic Hypogonadism. , 2016, Endocrine development.

[230]  W. Crowley,et al.  Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era. , 2016, Endocrine reviews.

[231]  A. Salonia,et al.  A critical analysis of the role of testosterone in erectile function: from pathophysiology to treatment-a systematic review. , 2014, European urology.

[232]  Michael G. Miller,et al.  A multicenter, open-label, observational study of testosterone gel (1%) in the treatment of adolescent boys with klinefelter syndrome or anorchia. , 2014, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[233]  M. Maggi,et al.  Standard operating procedures: pubertas tarda/delayed puberty--male. , 2013, The journal of sexual medicine.

[234]  S. Seminara,et al.  Kisspeptin and clinical disorders. , 2013, Advances in experimental medicine and biology.

[235]  Hollis G. Potter,et al.  Author Manuscript , 2013 .

[236]  V. Montori,et al.  Testosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials. , 2007, Mayo Clinic proceedings.

[237]  D. Gruenewald Aging and the Male Reproductive System , 2004 .

[238]  F. Andrade-Rocha Semen analysis in laboratory practice: An overview of routine tests , 2003, Journal of clinical laboratory analysis.

[239]  J. Toppari,et al.  Early postnatal treatment of hypogonadotropic hypogonadism with recombinant human FSH and LH. , 2002, European journal of endocrinology.

[240]  W. Crowley,et al.  Hypogonadotropic hypogonadism: gonadotropin-releasing hormone therapy. , 1994, Current therapy in endocrinology and metabolism.

[241]  Cyril Pearl,et al.  Government of the will. , 1842 .