Validating concepts of mental disorder: precedents from the history of science

A fundamental issue in any branch of the natural sciences is validating the basic concepts for use in that branch. In psychiatry, this issue has not yet been resolved, and indeed, the proper nature of the problem has scarcely been recognised. As a result, psychiatry (or at least those parts of the discipline which aspire to scientific status) still cannot claim to be a part of scientific medicine, or to be incorporated within the common language of the natural sciences. While this creates difficulties within the discipline, and its standing in relation to other branches of medicine, it makes it an exciting place for “frontiersmen” (and women). This is one of the key growing points in the natural science tradition. In this essay, which moves from the early history of that tradition to today’s debates in scientific psychiatry, I give my views about how these fundamental issues can move towards resolution.

[1]  S. Burger An Introduction to the Study of Experimental Medicine , 1950, The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha.

[2]  Harvey A Swadlow,et al.  Information Flow along Neocortical Axons , 2000 .

[3]  James L Olds,et al.  Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. , 1954, Journal of comparative and physiological psychology.

[4]  M. Boyle Schizophrenia: A Scientific Delusion? , 1990 .

[5]  Robert Miller,et al.  Axonal conduction time and human cerebral laterality : a psychobiological theory/ by Robert Miller , 1996 .

[6]  R. Beninger,et al.  Dopamine D1-like Receptors and Reward-related Incentive Learning , 1998, Neuroscience & Biobehavioral Reviews.

[7]  R. Miller,et al.  Schizophrenic psychology, associative learning and the role of forebrain dopamine. , 1976, Medical hypotheses.

[8]  Robert Miller,et al.  Distribution and properties of commissural and other neurons in cat sensorimotor cortex , 1975, The Journal of comparative neurology.

[9]  R. Miller Time and the brain , 2000 .

[10]  A. Frances Saving Normal: An Insider's Revolt Against Out-of-Control Psychiatric Diagnosis, DSM-5, Big Pharma, and the Medicalization of Ordinary Life , 2013 .

[11]  C. Elbro Dyslexia as Disability or Handicap: When Does Vocabulary Matter? , 2010, Journal of learning disabilities.

[12]  Dr. Robert Miller Cortico-Hippocampal Interplay and the Representation of Contexts in the Brain , 1991, Studies of Brain Function.

[13]  J. Wickens,et al.  Dopamine D-1 and D-2 receptors in relation to reward and performance: A case for the D-1 receptor as a primary site of therapeutic action of neuroleptic drugs , 1990, Progress in Neurobiology.

[14]  H. Markram,et al.  Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs , 1997, Science.

[15]  P. Flor-Henry,et al.  Psychosis and Temporal Lobe Epilepsy; A Controlled Investigation , 1969, Epilepsia.

[16]  C. Bernard Medical Classic. (Book Reviews: An Introduction to the Study of Experimental Medicine) , 1957 .

[17]  Michel Meulders Helmholtz: From Enlightenment to Neuroscience , 2010 .

[18]  M. Snowling,et al.  Cognitive assessment of dyslexic students in higher education. , 2002, The British journal of educational psychology.

[19]  Pierre Fler-Henry Psychosis and temporal lobe epilepsy , 1966 .

[20]  R. Beninger The role of dopamine in locomotor activity and learning , 1983, Brain Research Reviews.

[21]  H. Swadlow,et al.  Commissural transmission in humans. , 1979, Science.

[22]  H. Washington Deadly Monopolies: The Shocking Corporate Takeover of Life Itself--And the Consequences for Your Health and Our Medical Future , 2011 .

[23]  M. Studdert-Kennedy,et al.  Hemispheric specialization for speech perception. , 1970, The Journal of the Acoustical Society of America.

[24]  R. Beninger,et al.  Behavioral Effects of Clozapine and Dopamine Receptor Subtypes , 1997, Neuroscience & Biobehavioral Reviews.

[25]  S. Sizmur,et al.  Dangerous and severe personality disorder services , 2005 .

[26]  J. Read,et al.  Models of Madness : Psychological, Social and Biological Approaches to Schizophrenia , 2004 .