Self-assembly of diphenylalanine peptide with controlled polarization for power generation

Peptides have attracted considerable attention due to their biocompatibility, functional molecular recognition and unique biological and electronic properties. The strong piezoelectricity in diphenylalanine peptide expands its technological potential as a smart material. However, its random and unswitchable polarization has been the roadblock to fulfilling its potential and hence the demonstration of a piezoelectric device remains lacking. Here we show the control of polarization with an electric field applied during the peptide self-assembly process. Uniform polarization is obtained in two opposite directions with an effective piezoelectric constant d33 reaching 17.9 pm V−1. We demonstrate the power generation with a peptide-based power generator that produces an open-circuit voltage of 1.4 V and a power density of 3.3 nW cm−2. Devices enabled by peptides with controlled piezoelectricity provide a renewable and biocompatible energy source for biomedical applications and open up a portal to the next generation of multi-functional electronics compatible with human tissue.

[1]  Gil Rosenman,et al.  Piezoelectric Effect in Human Bones Studied in Nanometer Scale , 2004 .

[2]  Maria Dimaki,et al.  Manipulation of self‐assembly amyloid peptide nanotubes by dielectrophoresis , 2008, Electrophoresis.

[3]  Leming Sun,et al.  Bioinspired fluorescent dipeptide nanoparticles for targeted cancer cell imaging and real-time monitoring of drug release. , 2016, Nature nanotechnology.

[4]  S. Allen,et al.  Using the bending beam model to estimate the elasticity of diphenylalanine nanotubes. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[5]  Shuguang Zhang.  Fabrication of novel biomaterials through molecular self-assembly , 2003, Nature Biotechnology.

[6]  J. Tovar,et al.  Demonstration of Hole Transport and Voltage Equilibration in Self-Assembled π-Conjugated Peptide Nanostructures Using Field-Effect Transistor Architectures. , 2015, ACS nano.

[7]  A. S. Sigov,et al.  Temperature-driven phase transformation in self-assembled diphenylalanine peptide nanotubes , 2010 .

[8]  E. Fukada.  Piezoelectric properties of biological polymers , 1983, Quarterly Reviews of Biophysics.

[9]  Junbai Li,et al.  Controlled rod nanostructured assembly of diphenylalanine and their optical waveguide properties. , 2015, ACS nano.

[10]  J. Tovar,et al.  Peptide π-Electron Conjugates: Organic Electronics for Biology? , 2015, Bioconjugate chemistry.

[11]  Ehud Gazit,et al.  Strong piezoelectricity in bioinspired peptide nanotubes. , 2010, ACS nano.

[12]  I. Delgadillo,et al.  Polarization switching and patterning in self-assembled peptide tubular structures , 2012 .

[13]  Vladimir Ya. Shur,et al.  Piezoelectric properties of diphenylalanine microtubes prepared from the solution , 2016 .

[14]  Carl Henrik Görbitz,et al.  Microporous organic materials from hydrophobic dipeptides. , 2007, Chemistry.

[15]  M. Ghadiri,et al.  Design of self-assembling peptide nanotubes with delocalized electronic states. , 2006, Small.

[16]  Ramamoorthy Ramesh,et al.  Virus-based piezoelectric energy generation. , 2012, Nature nanotechnology.

[17]  N. Buchete,et al.  Nanoscale Piezoelectric Properties of Self-Assembled Fmoc-FF Peptide Fibrous Networks. , 2015, ACS applied materials & interfaces.

[18]  Eiichi Fukada,et al.  On the Piezoelectric Effect of Bone , 1957 .

[19]  N. Buchete,et al.  Conformational dynamics and aggregation behavior of piezoelectric diphenylalanine peptides in an external electric field. , 2015, Biophysical chemistry.

[20]  Gerhard M. Sessler,et al.  Piezoelectricity in cellular electret films , 2000 .

[21]  E. Gazit,et al.  Controlled patterning of aligned self-assembled peptide nanotubes , 2006, Nature nanotechnology.

[22]  P. Chu,et al.  Charged diphenylalanine nanotubes and controlled hierarchical self-assembly. , 2011, ACS nano.

[23]  Kory Jenkins,et al.  Epitaxial growth of vertically aligned piezoelectric diphenylalanine peptide microrods with uniform polarization , 2015 .

[24]  P. Chu,et al.  Effects of water molecules on photoluminescence from hierarchical peptide nanotubes and water probing capability. , 2011, Small.

[25]  N. Ashkenasy,et al.  Charge transport in vertically aligned, self-assembled peptide nanotube junctions. , 2012, Nanoscale.

[26]  J. Scheinbeim,et al.  Piezoelectric response of scleral collagen. , 1998, Journal of biomedical materials research.

[27]  Xuehai Yan,et al.  Self-Assembly and Application of Diphenylalanine-Based Nanostructures , 2010 .

[28]  Chuntae Kim,et al.  Bioinspired piezoelectric nanogenerators based on vertically aligned phage nanopillars , 2015 .

[29]  Yi Qi,et al.  Nanotechnology-enabled flexible and biocompatible energy harvesting , 2010 .

[30]  Sergei V. Kalinin,et al.  Electromechanical imaging of biomaterials by scanning probe microscopy. , 2006, Journal of structural biology.

[31]  Xinglong Wu,et al.  Unidirectionally aligned diphenylalanine nanotube/microtube arrays with excellent supercapacitive performance , 2014, Nano Research.

[32]  David Barlam,et al.  Self-assembled peptide nanotubes are uniquely rigid bioinspired supramolecular structures. , 2005, Nano letters.

[33]  Meital Reches,et al.  Novel electrochemical biosensing platform using self-assembled peptide nanotubes. , 2005, Nano letters.

[34]  A. Mata,et al.  Micropatterning of bioactive self-assembling gels. , 2009, Soft matter.

[35]  Zhong Lin Wang,et al.  Self-powered nanowire devices. , 2010, Nature nanotechnology.