Primary prevention of sexually transmitted diseases. A primer for clinicians.

With the advent of sexually transmitted infections for which curative therapy is not available, primary prevention has assumed greater importance. The spectrum of sexually transmitted diseases (STDs) has broadened, and clinicians need to understand the mechanisms of their transmission and prevention. Modifying selection of sexual partners and avoiding certain sexual practices should theoretically reduce the risk of infection. Clinical and laboratory studies indicate that the use of condoms, diaphragms, and spermicides reduces the risk of acquiring certain infections. At present, hepatitis B is the only STD for which a safe, effective vaccine is available. Use of oral antibiotics cannot be recommended. Postcoital washing or urination have not been shown to have a protective effect against infection. Because of the potential benefits, persons at risk for STDs should be encouraged to modify their sexual behavior and use barrier methods and spermicides to protect themselves against sexually transmitted infections.

[1]  D. Francis,et al.  INACTIVATION OF HTLV-III/LAV-INFECTED CULTURES OF NORMAL HUMAN LYMPHOCYTES BY NONOXYNOL-9 IN VITRO , 1985, The Lancet.

[2]  Association between diaphragm use and urinary tract infection. , 1985, JAMA.

[3]  Quinn Rw,et al.  Contraceptive practices of women attending the Sexually Transmitted Disease Clinic in Nashville Tennessee. , 1985 .

[4]  T. Coates,et al.  AIDS and sexual behavior reported by gay men in San Francisco. , 1985, American journal of public health.

[5]  M. Bracken Spermicidal contraceptives and poor reproductive outcomes: the epidemiologic evidence against an association. , 1985, American journal of obstetrics and gynecology.

[6]  W. Cates,et al.  Genital herpes: does knowledge lead to action? , 1985, American journal of public health.

[7]  W. Pratt,et al.  Understanding U.S. fertility: findings from the National Survey of Family Growth, Cycle III. , 1984, Population bulletin.

[8]  M. Meyer,et al.  The effect of chemical intravaginal contraceptives and Betadine on Ureaplasma urealyticum. , 1984, Contraception.

[9]  K. Syrjänen,et al.  Sexual behaviour of women with human papillomavirus (HPV) lesions of the uterine cervix. , 1984, The British journal of venereal diseases.

[10]  S. Katznelson,et al.  Efficacy of the condom as a barrier to the transmission of cytomegalovirus. , 1984, The Journal of infectious diseases.

[11]  H. Austin,et al.  A case-control study of spermicides and gonorrhea. , 1984, JAMA.

[12]  W. Stamm Prevention of urinary tract infections. , 1984, The American journal of medicine.

[13]  Creed D Smith,et al.  Herpes Simplex Virus Transmission: Condom Studies , 1984, Sexually transmitted diseases.

[14]  Rose Ds,et al.  Sexually transmitted diseases and carcinogenesis. , 1984 .

[15]  S. Morse,et al.  Changing trends in gonococcal antibiotic resistance in the United States, 1983-1984. , 1984, MMWR. CDC surveillance summaries : Morbidity and mortality weekly report. CDC surveillance summaries.

[16]  G. Schoolnik,et al.  A pilus peptide vaccine for the prevention of gonorrhea. , 1983, Progress in allergy.

[17]  S. Margolis Therapy for Condyloma Acuminatum: A Review , 1982 .

[18]  K. Rothman,et al.  Vaginal spermicides and gonorrhea. , 1982, JAMA.

[19]  D. Lewison,et al.  Update on condoms--products, protection, promotion. , 1982, Population reports. Series H, Barrier methods.

[20]  P. Layde,et al.  Barrier-method contraceptives and pelvic inflammatory disease. , 1982, JAMA.

[21]  B. Singh,et al.  Demonstration of a spirocheticidal effect by chemical contraceptives on Treponema pallidum. , 1982, Bulletin of the Pan American Health Organization.

[22]  Characteristics of women with dysplasia or carcinoma in situ of the cervix uteri. , 1980, British Journal of Cancer.

[23]  G. Marion-Landais,et al.  A controlled comparative study of phenylmercuric acetate nonoxynol-9 and placebo vaginal suppositories as prophylactic agents against gonorrhea. , 1980 .

[24]  K. Holmes,et al.  A trial of minocycline given after exposure to prevent gonorrhea. , 1979, The New England journal of medicine.

[25]  K. Holmes,et al.  Cohort study of venereal disease. I: the risk of gonorrhea transmission from infected women to men. , 1978, American journal of epidemiology.

[26]  A. Limsuwan,et al.  A clinical trial of a vaginal preparation regimen for the prophylaxis of gonorrhea. , 1978, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[27]  R. Doll,et al.  Neoplasia and dysplasia of the cervix uteri and contraception: a possible protective effect of the diaphragm. , 1978, British Journal of Cancer.

[28]  D. Barlow THE CONDOM AND GONORRHŒA , 1977, The Lancet.

[29]  B. Singh,et al.  Vaginal contraceptives as prophylaxis against gonorrhea and other sexually transmissible diseases. , 1977 .

[30]  B. Singh,et al.  Virucidal effect of certain chemical contraceptives on Type 2 herpesvirus. , 1976, American journal of obstetrics and gynecology.

[31]  G. Hart Factors influencing venereal infection in a war environment. , 1974, The British journal of venereal diseases.

[32]  Edwards Wm A study of progonasyl using prostitutes in Nevada's legal houses of prostitution. , 1973 .

[33]  Stock Rj,et al.  Vaginal douching. Current concepts and practices. , 1973 .

[34]  W. Mccormack,et al.  Sexual experience and urethral colonization with genital mycoplasmas. A study in normal men. , 1973, Annals of internal medicine.

[35]  J. C. Warren,et al.  In vitro effects of Emko on Neisseria gonorrhoeae and Trichomonas vaginalis. , 1973, American journal of obstetrics and gynecology.

[36]  H. Utidjian,et al.  Studies on the development of a vaginal preparation providing both prophylaxis against venereal disease and other genital infections and contraception. II. Effect in vitro of vaginal contraceptive and non-contraceptive preparations on Treponema pallidum and Neisseria gonorrhoeae. , 1972, The British journal of venereal diseases.

[37]  Regalla Sa,et al.  Use of doxycycline as a preventive measure of venereal infections among naval mission participants , 1969 .

[38]  H. Eagle,et al.  Prevention of gonorrhea with penicillin tablets. , 1949, Journal of the American Medical Association.

[39]  James A. Loveless,et al.  THE ORAL USE OF SULFATHIAZOLE AS A PROPHYLAXIS FOR GONORRHEA: PRELIMINARY REPORT , 1943 .