Successful treatment of refractory Hodgkin's disease by high-dose combination chemotherapy and autologous bone marrow transplantation.

Forty-four patients with refractory Hodgkin's disease were treated with high-dose combination chemotherapy followed by autologous bone marrow rescue. Twenty-two patients (50%) entered complete remission within 6 months of the procedure and four other patients are free of disease progression. Only two patients have subsequently relapsed from complete remission (CR). Bone marrow suppression was the predictable major toxicity of this procedure, and two patients (4.5%) died of sepsis during the aplastic phase. High-dose therapy with autologous bone marrow transplantation (ABMT) appears to be an effective salvage regimen for patients with refractory Hodgkin's disease.

[1]  A. Avilés,et al.  Hodgkin's disease. A historical perspective. , 1991, Archivos de investigacion medica.

[2]  D Crowther,et al.  The significance of residual mediastinal abnormality on the chest radiograph following treatment for Hodgkin's disease. , 1988, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[3]  J. Gribben,et al.  The potential value of very intensive therapy with autologous bone marrow rescue in the treatment of malignant lymphomas , 1987, Hematological oncology.

[4]  P. Hervé,et al.  High dose chemotherapy and autologous bone marrow transplantation in refractory Hodgkin's disease. , 1986, British Journal of Cancer.

[5]  J. Armitage,et al.  High-dose cyclophosphamide, carmustine, and etoposide and autologous bone marrow transplantation for relapsed Hodgkin's disease. , 1986, Annals of internal medicine.

[6]  D. Reece,et al.  Clinical studies of autologous bone marrow transplantation in Hodgkin's disease. , 1986, Clinics in haematology.

[7]  D. Huhn,et al.  Assessment of bone marrow histology in Hodgkin's disease: correlation with clinical factors , 1982, British journal of haematology.

[8]  A. Santoro,et al.  Salvage chemotherapy with ABVD in MOPP-resistant Hodgkin's disease. , 1982, Annals of internal medicine.

[9]  D. Linch,et al.  Bone marrow processing and cryopreservation. , 1982, Journal of clinical pathology.

[10]  E. Frei,et al.  Dose: a critical factor in cancer chemotherapy. , 1980, The American journal of medicine.

[11]  V. Devita,et al.  Combination chemotherapy for advanced Hodgkin's disease in relapse following extensive radiotherapy , 1972, Clinical pharmacology and therapeutics.