The economics of additive manufacturing: Towards a general cost model including process failure

Abstract The interest in Additive Manufacturing (AM) technology, also known as 3D printing, is unbroken. In many industries, however, stakeholders are struggling to understand AM’s potential for manufacturing value creation. Most available literature on the cost of AM stresses the importance of ancillary processes and treats the relationship between process efficiency and capacity utilization. The most recently added - and overdue - aspect included in the extant AM costing literature considers the expected impact of so-called ill-structured costs, mainly relating to process failure and product rejection. Available research has investigated this aspect across a variety of technology types and process elements. This paper develops a new AM cost model that is generally specified so it can represent the probability and expected cost effect of failure events for all existing AM technologies. To demonstrate the implementation of this model, this paper applies it to the manufacture of pharmaceutical products (tablets) using the AM technology variant material jetting. The paper thus provides a robust indication of achievable unit cost levels, the cost effect of process failure, and also broaches the usefulness of cost models in guiding further process improvements.

[1]  L. D. Angelo,et al.  A neural network-based build time estimator for layer manufactured objects , 2011 .

[2]  Martin Baumers Cost Implications of Precision Additive Manufacturing , 2020 .

[3]  M. Cima,et al.  Multimechanism oral dosage forms fabricated by three dimensional printing. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[4]  Richard J.M. Hague,et al.  The cost of additive manufacturing: machine productivity, economies of scale and technology-push , 2016 .

[5]  A. Bandyopadhyay,et al.  Additive manufacturing: scientific and technological challenges, market uptake and opportunities , 2017 .

[6]  Richard J.M. Hague,et al.  Cost estimation for rapid manufacturing ’ simultaneous production of mixed components using laser sintering , 2007 .

[7]  Eleonora Atzeni,et al.  Economics of additive manufacturing for end-usable metal parts , 2012 .

[8]  Ian Ashcroft,et al.  3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[9]  Ian Gibson,et al.  Additive manufacturing technologies : 3D printing, rapid prototyping, and direct digital manufacturing , 2015 .

[10]  D. Tranfield,et al.  Developing Design Propositions through Research Synthesis , 2008 .

[11]  Richard J.M. Hague,et al.  Cost estimation for rapid manufacturing - laser sintering production for low to medium volumes , 2006 .

[12]  A. Basit,et al.  Effect of geometry on drug release from 3D printed tablets. , 2015, International journal of pharmaceutics.

[13]  M. Alexander,et al.  Desktop 3D printing of controlled release pharmaceutical bilayer tablets. , 2014, International journal of pharmaceutics.

[14]  M. Holweg,et al.  COST IMPACT OF THE RISK OF BUILD FAILURE IN LASER SINTERING , 2016 .

[15]  Young K. Son,et al.  A cost estimation model for advanced manufacturing systems , 1991 .

[16]  M. A. Alhnan,et al.  A flexible-dose dispenser for immediate and extended release 3D printed tablets. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[17]  Stergios Maropoulos,et al.  Process build‐time estimator algorithm for laminated object manufacturing , 2004 .

[18]  P. Chatzoglou,et al.  A survey on the 3D printing technology readiness to use , 2019, Int. J. Prod. Res..

[19]  Massimiliano Ruffo,et al.  Rapid manufacturing facilitated customization , 2008, Int. J. Comput. Integr. Manuf..

[20]  Enno Siemsen,et al.  Decentralization and Localization of Production , 2017 .

[21]  Bianca Maria Colosimo,et al.  A cost model for the economic evaluation of in-situ monitoring tools in metal additive manufacturing , 2020 .

[22]  Aravind Chandrasekaran,et al.  Conducting and publishing design science research: Inaugural essay of the design science department of the Journal of Operations Management , 2016 .

[23]  Lin Li,et al.  Cost modeling and analysis for Mask Image Projection Stereolithography additive manufacturing: Simultaneous production with mixed geometries , 2018, International Journal of Production Economics.

[24]  Baoyang Ding Pharma Industry 4.0: Literature review and research opportunities in sustainable pharmaceutical supply chains , 2018, Process Safety and Environmental Protection.

[25]  Eleonora Atzeni,et al.  Redesign and cost estimation of rapid manufactured plastic parts , 2010 .

[26]  Richard J.M. Hague,et al.  Informing additive manufacturing technology adoption: total cost and the impact of capacity utilisation , 2017, Int. J. Prod. Res..

[27]  Simon Gaisford,et al.  Selective laser sintering (SLS) 3D printing of medicines. , 2017, International journal of pharmaceutics.

[28]  M. Alexander,et al.  3D printing of tablets containing multiple drugs with defined release profiles. , 2015, International journal of pharmaceutics.

[29]  N Hopkinson,et al.  Analysis of rapid manufacturing—using layer manufacturing processes for production , 2003 .

[30]  Ricky D. Wildman,et al.  3D printing of tablets using inkjet with UV photoinitiation. , 2017, International journal of pharmaceutics.

[31]  David Cebon,et al.  Materials Selection in Mechanical Design , 1992 .

[32]  M. Khan,et al.  A new chapter in pharmaceutical manufacturing: 3D‐printed drug products☆, ☆☆ , 2017, Advanced drug delivery reviews.

[33]  Simon Gaisford,et al.  Reshaping drug development using 3D printing. , 2018, Drug discovery today.

[34]  R. Koch,et al.  Impact and Influence Factors of Additive Manufacturing on Product Lifecycle Costs , 2013 .

[35]  Lawrence X. Yu Pharmaceutical Quality by Design: Product and Process Development, Understanding, and Control , 2008, Pharmaceutical Research.

[36]  Emanuel M. Sachs,et al.  Solid free-form fabrication of drug delivery devices , 1996 .

[37]  Dimitrios I. Gerogiorgis,et al.  Economic Analysis of Integrated Continuous and Batch Pharmaceutical Manufacturing: A Case Study , 2011 .

[38]  Seth Allen,et al.  Part orientation and build cost determination in layered manufacturing , 1998, Comput. Aided Des..

[39]  A. Gazzaniga,et al.  3D printed multi‐compartment capsular devices for two‐pulse oral drug delivery , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[40]  Abdul W. Basit,et al.  Stereolithographic (SLA) 3D printing of oral modified-release dosage forms. , 2016, International journal of pharmaceutics.

[41]  David Z. Zhang,et al.  Additive manufacturing: A framework for implementation , 2014 .

[42]  Alain Bernard,et al.  Generic build time estimation model for parts produced by SLS , 2013 .

[43]  Niklas Sandler,et al.  Hyperspectral imaging in quality control of inkjet printed personalised dosage forms. , 2015, International journal of pharmaceutics.

[44]  David W. Rosen,et al.  Additive Manufacturing Technologies: Rapid Prototyping to Direct Digital Manufacturing , 2009 .

[45]  Yang Cheng,et al.  Additive manufacturing technology in spare parts supply chain: a comparative study , 2017, Int. J. Prod. Res..

[46]  Brett Lyons,et al.  Additive Manufacturing in Aerospace; Examples and Research Outlook , 2014 .

[47]  Ricky D. Wildman,et al.  Using total specific cost indices to compare the cost performance of additive manufacturing for the medical devices domain , 2018, Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture.

[48]  Martin Baumers,et al.  Developing an Understanding of the Cost of Additive Manufacturing , 2019 .

[49]  Konrad Wegener,et al.  An integrated cost‐model for selective laser melting (SLM) , 2013 .

[50]  F. Piller,et al.  Economic implications of 3D printing: Market structure models in light of additive manufacturing revisited , 2015 .

[51]  Matthias Holweg,et al.  On the economics of additive manufacturing: Experimental findings , 2019, Journal of Operations Management.

[52]  David W. Rosen,et al.  Build Time and Cost Models for Additive Manufacturing Process Selection , 2012 .

[53]  Simon Gaisford,et al.  3D Printing Pharmaceuticals: Drug Development to Frontline Care. , 2018, Trends in pharmacological sciences.

[54]  R. Schmenner,et al.  On theory in operations management , 1998 .

[55]  J. Rantanen,et al.  The Future of Pharmaceutical Manufacturing Sciences , 2015, Journal of pharmaceutical sciences.