Mining Brain Tumors and Tracking their Growth Rates

Mining brain tumors and tracking their growth trends in the course of magnetic resonance imaging is an important task that assists medical professionals to describe the appropriate treatment. Nevertheless, applying conventional techniques to carry out this process manually is time-consuming and often unreliable and insufficiently accurate. Automating this process is a challenging task due to the fact of the fractal shape of tumor and its biological structure, which is often, has a high degree of intensity and textural similarity between normal areas and tumor tissues. Moreover, tumor uptake measurements are not easy given the small size of many tumors, the limitations of spatial resolution, and the change of tumor location from slice to slice across the brain. Furthermore, the arbitrary shape of tumors makes it extremely hard, if not impossible, to adopt traditional geometric rules for tumor measurements. In this paper, we present a computational approach for modeling and mining a large number of MRI data for patients with brain tumors. In this approach, we adopt a spatial data mining technique to extract useful information from MRI data in order to identify the size of tumors and growth trend, as well as classifying tumors of patients upon specific similarity measures.

[1]  Paul Thompson,et al.  Mapping tumor growth rates in patients with malignant gliomas: A test of two algorithms , 2000, NeuroImage.

[2]  Ron Kohavi,et al.  Supervised and Unsupervised Discretization of Continuous Features , 1995, ICML.

[3]  Pedro M. Domingos,et al.  On the Optimality of the Simple Bayesian Classifier under Zero-One Loss , 1997, Machine Learning.

[4]  R P Velthuizen,et al.  Comparison of supervised MRI segmentation methods for tumor volume determination during therapy. , 1995, Magnetic resonance imaging.

[5]  Andrew McCallum,et al.  A comparison of event models for naive bayes text classification , 1998, AAAI 1998.

[6]  L. Clarke,et al.  MRI measurement of brain tumor response: comparison of visual metric and automatic segmentation. , 1998, Magnetic resonance imaging.

[7]  Jiayin Zhou,et al.  MRI Tumor Segmentation for Nasopharyngeal Carcinoma Using Knowledge-based Fuzzy Clustering , 2002 .

[8]  R P Velthuizen,et al.  MRI segmentation: methods and applications. , 1995, Magnetic resonance imaging.

[9]  D. Hand,et al.  Idiot's Bayes—Not So Stupid After All? , 2001 .

[10]  Martin Mozina,et al.  Nomograms for Visualization of Naive Bayesian Classifier , 2004, PKDD.

[11]  M. E. Maron,et al.  Automatic Indexing: An Experimental Inquiry , 1961, JACM.

[12]  Tuan-Kay Lim,et al.  Nasopharyngeal carcinoma tumor volume measurement.. , 2004, Radiology.

[13]  Thomas J. Watson,et al.  An empirical study of the naive Bayes classifier , 2001 .

[14]  C. Meltzer,et al.  Brain tumor volume measurement: comparison of manual and semiautomated methods. , 1999, Radiology.

[15]  F. Parandoosh,et al.  Evaluating Agent-Oriented Software Engineering Methodologies , 2007, 2007 2nd International Workshop on Soft Computing Applications.