FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p

[1]  B. Kingwell,et al.  HDL-targeted therapies: progress, failures and future , 2014, Nature Reviews Drug Discovery.

[2]  John A. Tallarico,et al.  High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions. , 2014, Microbiological research.

[3]  K. Koh,et al.  How to balance cardiorenometabolic benefits and risks of statins. , 2013, Atherosclerosis.

[4]  K. Broman,et al.  Identification of a Novel Polymorphism in X-Linked Sterol-4-Alpha-Carboxylate 3-Dehydrogenase (Nsdhl) Associated with Reduced High-Density Lipoprotein Cholesterol Levels in I/LnJ Mice , 2013, G3: Genes, Genomes, Genetics.

[5]  C. Rice,et al.  Understanding the hepatitis C virus life cycle paves the way for highly effective therapies , 2013, Nature Medicine.

[6]  Charles Boone,et al.  Systems-level antimicrobial drug and drug synergy discovery. , 2013, Nature chemical biology.

[7]  Jeffrey A. Porter,et al.  An Integrated Approach for Identification and Target Validation of Antifungal Compounds Active against Erg11p , 2012, Antimicrobial Agents and Chemotherapy.

[8]  Adam A. Margolin,et al.  The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity , 2012, Nature.

[9]  J. Pemán,et al.  Antifungal Susceptibility Testing of Filamentous Fungi , 2012, Current Fungal Infection Reports.

[10]  A. Siddiqui,et al.  Effects of hypolipidemic agent nordihydroguaiaretic acid on lipid droplets and hepatitis C virus , 2011, Hepatology.

[11]  Steven J. M. Jones,et al.  Hypomorphic temperature-sensitive alleles of NSDHL cause CK syndrome. , 2010, American journal of human genetics.

[12]  A. Siddiqui,et al.  Hepatitis C virus hijacks host lipid metabolism , 2010, Trends in Endocrinology & Metabolism.

[13]  Rodney K. Lyn,et al.  Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism. , 2009, Virology.

[14]  W. de Souza,et al.  Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs , 2009, Interdisciplinary perspectives on infectious diseases.

[15]  M. Labow,et al.  Cholesterol biosynthesis modulation regulates dengue viral replication. , 2009, Virology.

[16]  Pascal Benkert,et al.  QMEAN server for protein model quality estimation , 2009, Nucleic Acids Res..

[17]  D. Botstein,et al.  A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds , 2009, Nature Biotechnology.

[18]  M. Bergdoll,et al.  Homology Modeling and Site-Directed Mutagenesis Reveal Catalytic Key Amino Acids of 3β-Hydroxysteroid-Dehydrogenase/C4-Decarboxylase from Arabidopsis[C][W] , 2009, Plant Physiology.

[19]  Susan E. Abbatiello,et al.  Erratum: Synergistic drug combinations tend to improve therapeutically relevant selectivity , 2009, Nature Biotechnology.

[20]  Liisa Holm,et al.  Searching protein structure databases with DaliLite v.3 , 2008, Bioinform..

[21]  Jin-cui Ye.  Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus , 2007, PLoS pathogens.

[22]  W. Du,et al.  Miconazole Induces Changes in Actin Cytoskeleton prior to Reactive Oxygen Species Induction in Yeast* , 2007, Journal of Biological Chemistry.

[23]  M. Bard,et al.  Molecular and Enzymatic Characterizations of Novel Bifunctional 3β-Hydroxysteroid Dehydrogenases/C-4 Decarboxylases from Arabidopsis thaliana* , 2006, Journal of Biological Chemistry.

[24]  Stuart L Schreiber,et al.  Small molecules: the missing link in the central dogma , 2005, Nature chemical biology.

[25]  K. Sakamoto,et al.  FR171456, a novel cholesterol synthesis inhibitor produced by Sporormiella minima No. 15604. I. Taxonomy, fermentation, isolation, physico-chemical properties. , 2004, The Journal of antibiotics.

[26]  M. Hino,et al.  FR171456, a novel cholesterol synthesis inhibitor produced by Sporormiella minima No. 15604. II. Biological activities. , 2004, The Journal of antibiotics.

[27]  H. Caldas,et al.  NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets. , 2003, Human molecular genetics.

[28]  A. Rahier,et al.  Enzymological properties of sterol-C4-methyl-oxidase of yeast sterol biosynthesis. , 2003, Biochimica et biophysica acta.

[29]  J. Heitman,et al.  Ergosterol Biosynthesis Inhibitors Become Fungicidal when Combined with Calcineurin Inhibitors against Candida albicans, Candida glabrata, and Candida krusei , 2003, Antimicrobial Agents and Chemotherapy.

[30]  R. Bartenschlager.  Hepatitis C virus replicons: potential role for drug development , 2002, Nature Reviews Drug Discovery.

[31]  M. Bard,et al.  Protein–protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[32]  M. Germann,et al.  The Effect of the erg26-1 Mutation on the Regulation of Lipid Metabolism in Saccharomyces cerevisiae * , 2001, The Journal of Biological Chemistry.

[33]  M. Germann,et al.  The Effect of the erg 26-1 Mutation on the Regulation of Lipid Metabolism in Saccharomyces cerevisiae * , 2001 .

[34]  G. Herman,et al.  X-Linked dominant disorders of cholesterol biosynthesis in man and mouse. , 2000, Biochimica et biophysica acta.

[35]  M. Bard,et al.  Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[36]  S. Rondet.  Biosynthese des sterols : 4-carboxy-sterol decarboxylases de plante superieure et de levure ; identification, caracterisation et purification , 1998 .

[37]  J. Thompson,et al.  The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. , 1997, Nucleic acids research.

[38]  A Sali,et al.  Comparative protein modeling by satisfaction of spatial restraints. , 1996, Molecular medicine today.

[39]  G. Dixon,et al.  Ergosterol biosynthesis inhibition: a target for antifungal agents. , 1995, Acta biochimica Polonica.

[40]  F. Odds,et al.  Molecular mechanisms of drug resistance in fungi. , 1994, Trends in microbiology.

[41]  T. Blundell,et al.  Comparative protein modelling by satisfaction of spatial restraints. , 1993, Journal of molecular biology.

[42]  E. Mercer.  Inhibitors of sterol biosynthesis and their applications. , 1993, Progress in lipid research.

[43]  J. Heitman,et al.  Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast , 1991, Science.

[44]  J. Goldstein,et al.  Scavenging for receptors , 1990, Nature.

[45]  M. Brown,et al.  Atherosclerosis. Scavenging for receptors. , 1990, Nature.

[46]  H. Sambrook.  Molecular cloning : a laboratory manual. Cold Spring Harbor, NY , 1989 .

[47]  M. Basson,et al.  Identifying mutations in duplicated functions in Saccharomyces cerevisiae: recessive mutations in HMG-CoA reductase genes. , 1987, Genetics.

[48]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[49]  A. Chou,et al.  Rat brain hexokinase: glucose and glucose-6-phosphate binding sites and C-terminal amino acid of the purified enzyme. , 1974, Archives of biochemistry and biophysics.