Effect of intracortical bone properties on the phase velocity and cut-off frequency of low-frequency guided wave modes (20-85 kHz).

The assessment of intracortical bone properties is of interest since early-stage osteoporosis is associated with resorption in the endosteal region. However, understanding the interaction between ultrasonic guided waves and the cortical bone structure remains challenging. The purpose of this work is to investigate the effect of intracortical bone properties on the ultrasonic response obtained at low-frequency (<100 kHz) using an axial transmission configuration. The semi-analytical finite element method was used to simulate the propagation of guided waves in a waveguide with realistic geometry and material properties. An array of 20 receivers was used to calculate the phase velocity and cut-off frequency of the excited modes using the two-dimensional Fourier transform. The results show that the position of the emitter around the circumference of the bone is an important parameter to control since it can lead to variations of up to 10 dB in the amplitude of the transmitted modes. The cut-off frequency of the high order modes was, however, only slightly affected by the circumferential position of the emitter, and was sensitive mainly to the axial shear modulus. The phase velocity and cut-off frequency in the 20-85 kHz range are promising parameters for the assessment of intracortical properties.

[1]  Jean-Gabriel Minonzio,et al.  Combined estimation of thickness and velocities using ultrasound guided waves: a pioneering study on in vitro cortical bone samples , 2014, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[2]  P. Loveday,et al.  Simulation of piezoelectric excitation of guided waves using waveguide finite elements , 2008, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[3]  C. Gluer A new quality of bone ultrasound research , 2008, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[4]  Christian Soize,et al.  Influence of viscoelastic and viscous absorption on ultrasonic wave propagation in cortical bone: Application to axial transmission. , 2010, The Journal of the Acoustical Society of America.

[5]  J. Timonen,et al.  Tailoring the excitation of fundamental flexural guide waves in coated bone by phase-delayed array: two-dimensional simulations. , 2015, Journal of the Acoustical Society of America.

[6]  Vu-Hieu Nguyen,et al.  Semi-analytical solution of transient plane waves transmitted through a transversely isotropic poroelastic plate immersed in fluid , 2014 .

[7]  Jean-Gabriel Minonzio,et al.  A free plate model can predict guided modes propagating in tubular bone-mimicking phantoms. , 2015, The Journal of the Acoustical Society of America.

[8]  Maryline Talmant,et al.  Comparison of three ultrasonic axial transmission methods for bone assessment. , 2005, Ultrasound in medicine & biology.

[9]  S. Cummings,et al.  Which Fractures Are Associated with Low Appendicular Bone Mass in Elderly Women , 1991 .

[10]  C. Sanborn,et al.  Bone health and osteoporosis. , 2000, Clinics in sports medicine.

[11]  M Castaings,et al.  Torsional waves propagation along a waveguide of arbitrary cross section immersed in a perfect fluid. , 2008, The Journal of the Acoustical Society of America.

[12]  M. Castaings,et al.  Wave propagation along transversely periodic structures. , 2007, The Journal of the Acoustical Society of America.

[13]  H. Rico The Therapy of Osteoporosis and the Importance of Cortical Bone , 1997, Calcified Tissue International.

[14]  Glüer Cc Quantitative ultrasound techniques for the assessment of osteoporosis: expert agreement on current status. The International Quantitative Ultrasound Consensus Group. , 1997 .

[15]  J. Compston,et al.  Assessment of fracture risk and its application to screening for postmenopausal osteoporosis (WHO Technical Report Series No 843) , 1995 .

[16]  M. Hahn,et al.  The Thickness of Human Vertebral Cortical Bone and its Changes in Aging and Osteoporosis: A Histomorphometric Analysis of the Complete Spinal Column from Thirty‐Seven Autopsy Specimens , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[17]  F Peyrin,et al.  Determination of the heterogeneous anisotropic elastic properties of human femoral bone: from nanoscopic to organ scale. , 2010, Journal of biomechanics.

[18]  G. Proctor,et al.  Clinical assessment , 2014, BDJ.

[19]  Gangming Luo,et al.  Clinical assessment of the 1/3 radius using a new desktop ultrasonic bone densitometer. , 2013, Ultrasound in medicine & biology.

[20]  M. Bouxsein,et al.  Premenopausal women with a distal radial fracture have deteriorated trabecular bone density and morphology compared with controls without a fracture. , 2013, The Journal of bone and joint surgery. American volume.

[21]  P.H.F. Nicholson,et al.  Ultrasound and the biomechanical competence of bone , 2008, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[22]  P. Bélanger,et al.  Semi-analytical finite-element modeling approach for guided wave assessment of mechanical degradation in bones , 2017, International Biomechanics.

[23]  Armen Sarvazyan,et al.  Application of the dual-frequency ultrasonometer for osteoporosis detection. , 2009, Ultrasonics.

[24]  L. Giangregorio,et al.  Fragility fractures and the osteoporosis care gap: an international phenomenon. , 2006, Seminars in arthritis and rheumatism.

[25]  Thomas A. Einhorn,et al.  Perspectives: Ultrasound assessment of bone , 1993 .

[26]  Armen Sarvazyan,et al.  Use of multiple acoustic wave modes for assessment of long bones: model study. , 2005, Ultrasonics.

[27]  Jean-Gabriel Minonzio,et al.  Measuring the wavenumber of guided modes in waveguides with linearly varying thickness. , 2014, Journal of the Acoustical Society of America.

[28]  Mauricio D. Sacchi,et al.  Computing dispersion curves of elastic/viscoelastic transversely-isotropic bone plates coupled with soft tissue and marrow using semi-analytical finite element (SAFE) method , 2017, Comput. Biol. Medicine.

[29]  C. Cooper,et al.  Osteoporosis: burden, health care provision and opportunities in the EU , 2011, Archives of osteoporosis.

[30]  Peter Cawley,et al.  A 2-dimensional Fourier transform method for the quantitative measurement of Lamb modes , 1990, IEEE Symposium on Ultrasonics.

[31]  L. Giangregorio,et al.  The osteoporosis care gap in Canada , 2004, BMC musculoskeletal disorders.

[32]  P. Wilcox,et al.  The excitation and detection of Lamb waves with planar coil electromagnetic acoustic transducers , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[33]  S. Cummings,et al.  Which fractures are associated with low appendicular bone mass in elderly women? The Study of Osteoporotic Fractures Research Group. , 1992, Annals of internal medicine.

[34]  Vu-Hieu Nguyen,et al.  Sensitivity analysis of ultrasonic guided waves propagating in trilayered bone models: a numerical study , 2018, Biomechanics and Modeling in Mechanobiology.

[35]  R. Bader,et al.  Bone Mineral Densities and Mechanical Properties of Retrieved Femoral Bone Samples in relation to Bone Mineral Densities Measured in the Respective Patients , 2012, TheScientificWorldJournal.

[36]  Zhongqing Su,et al.  On ultrasound waves guided by bones with coupled soft tissues: a mechanism study and in vitro calibration. , 2014, Ultrasonics.