A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation

[1]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[2]  E. Goldsmith,et al.  Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation , 1998, Cell.

[3]  G. Bokoch,et al.  Membrane targeting of p21‐activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells , 1998, The EMBO journal.

[4]  G. Tocchini-Valentini,et al.  Efficient signal transduction by a chimeric yeast–mammalian G protein α subunit Gpa1–Gsα covalently fused to the yeast receptor Ste2 , 1997 .

[5]  Paul Shapiro,et al.  Cross‐cascade activation of ERKs and ternary complex factors by Rho family proteins , 1997, The EMBO journal.

[6]  Elizabeth J. Goldsmith,et al.  Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation , 1997, Cell.

[7]  G. Milligan,et al.  Measurement of agonist-induced guanine nucleotide turnover by the G-protein Gi1alpha when constrained within an alpha2A-adrenoceptor-Gi1alpha fusion protein. , 1997, The Biochemical journal.

[8]  P. Warne,et al.  Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras , 1997, Cell.

[9]  E. Nishida,et al.  Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase , 1997, The EMBO journal.

[10]  M. Cobb,et al.  Mitogen-activated protein kinase pathways. , 1997, Current opinion in cell biology.

[11]  N. Ahn,et al.  Interdependent domains controlling the enzymatic activity of mitogen-activated protein kinase kinase 1. , 1996, Biochemistry.

[12]  P. Shaw,et al.  Selective response of ternary complex factor Sap1a to different mitogen-activated protein kinase subgroups. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[13]  E. Nishida,et al.  Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal* , 1996, The Journal of Biological Chemistry.

[14]  M. Kohno,et al.  Characterization of the Bone Morphogenetic Protein-2 as a Neurotrophic Factor , 1996, The Journal of Biological Chemistry.

[15]  E. Goldsmith,et al.  Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate. , 1996, Biochemistry.

[16]  P. Lampe,et al.  Characterization of the Mitogen-activated Protein Kinase Phosphorylation Sites on the Connexin-43 Gap Junction Protein (*) , 1996, The Journal of Biological Chemistry.

[17]  L. Heasley,et al.  GTPase-deficient G alpha 16 and G alpha q induce PC12 cell differentiation and persistent activation of cJun NH2-terminal kinases , 1996, Molecular and cellular biology.

[18]  Philip R. Cohen,et al.  PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*) , 1995, The Journal of Biological Chemistry.

[19]  C. Der,et al.  Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation , 1995, Molecular and cellular biology.

[20]  E. Krebs,et al.  Association of mitogen-activated protein kinase with the microtubule cytoskeleton. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[21]  R. Stephens,et al.  Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis , 1995, Neuron.

[22]  E. Nishida,et al.  Induction of neurite outgrowth by MAP kinase in PC12 cells. , 1995, Oncogene.

[23]  L. Heasley,et al.  Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation , 1995, Molecular and cellular biology.

[24]  R. Treisman,et al.  Comparative analysis of the ternary complex factors Elk‐1, SAP‐1a and SAP‐2 (ERP/NET). , 1995, The EMBO journal.

[25]  F. McCormick,et al.  An essential role for Rac in Ras transformation , 1995, Nature.

[26]  K. Okazaki,et al.  MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos. , 1995, Oncogene.

[27]  A. Nordheim,et al.  SAP1a is a nuclear target of signaling cascades involving ERKs. , 1995, Oncogene.

[28]  C. Slaughter,et al.  ERK phosphorylation potentiates Elk‐1‐mediated ternary complex formation and transactivation. , 1995, The EMBO journal.

[29]  E. Goldsmith,et al.  Activity of the MAP kinase ERK2 is controlled by a flexible surface loop. , 1995, Structure.

[30]  M. Wigler,et al.  Multiple ras functions can contribute to mammalian cell transformation , 1995, Cell.

[31]  C. Marshall,et al.  Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation , 1995, Cell.

[32]  C. Marshall,et al.  The sevenmaker gain‐of‐function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action , 1994, FEBS letters.

[33]  N. Ahn,et al.  Transformation of mammalian cells by constitutively active MAP kinase kinase. , 1994, Science.

[34]  E. Hafen,et al.  A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways , 1994, Cell.

[35]  J. Avruch,et al.  Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation. , 1994, The Journal of biological chemistry.

[36]  Elizabeth J. Goldsmith,et al.  Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution , 1994, Nature.

[37]  A. Nordheim,et al.  Activation of ternary complex factor Elk‐1 by MAP kinases. , 1993, The EMBO journal.

[38]  R. Davis,et al.  Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus , 1993, The Journal of cell biology.

[39]  A. Brunet,et al.  Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts , 1993, The Journal of cell biology.

[40]  A. Lau,et al.  Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-0-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated protein kinase. , 1993, Molecular biology of the cell.

[41]  Jonathan A. Cooper,et al.  Mammalian Ras interacts directly with the serine/threonine kinase raf , 1993, Cell.

[42]  Jonathan A. Cooper,et al.  p42 mitogen-activated protein kinase in brain: Prominent localization in neuronal cell bodies and dendrites , 1993, Neuroscience.

[43]  M. Cobb,et al.  Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. , 1993, The Journal of biological chemistry.

[44]  G. Drewes,et al.  Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer‐like state. , 1992, The EMBO journal.

[45]  M. Cobb,et al.  Extracellular signal-regulated kinases in T cells. Anti-CD3 and 4 beta-phorbol 12-myristate 13-acetate-induced phosphorylation and activation. , 1992, Journal of immunology.

[46]  J. Blenis,et al.  Nuclear localization and regulation of erk- and rsk-encoded protein kinases , 1992, Molecular and cellular biology.

[47]  T. Sturgill,et al.  Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[48]  D. Bar-Sagi,et al.  Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation , 1985, Cell.

[49]  L. Greene,et al.  Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[50]  N. Ahn,et al.  Signal transduction through MAP kinase cascades. , 1998, Advances in cancer research.

[51]  Putidaredoxin Reductase-Putidaredoxin-Cytochrome P450 cam Triple Fusion Protein CONSTRUCTION OF A SELF-SUFFICIENT ESCHERICHIA COLI CATALYTIC SYSTEM* , 2022 .