The fundamental role of epigenetic events in cancer
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[1] Peter A. Jones,et al. Cell division is required for de novo methylation of CpG islands in bladder cancer cells. , 2002, Cancer research.
[2] J. P. Jackson,et al. Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase , 2002, Nature.
[3] Bert Vogelstein,et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells , 2002, Nature.
[4] A. Wolffe,et al. Precipitous Release of Methyl-CpG Binding Protein 2 and Histone Deacetylase 1 from the Methylated Human Multidrug Resistance Gene (MDR1) on Activation , 2002, Molecular and Cellular Biology.
[5] Daiya Takai,et al. Comprehensive analysis of CpG islands in human chromosomes 21 and 22 , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[6] David Sidransky,et al. Emerging molecular markers of cancer , 2002, Nature Reviews Cancer.
[7] Peter A. Jones,et al. Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2'-deoxycytidine. , 2002, Cancer research.
[8] S. Minucci,et al. Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor , 2002, Science.
[9] Yudong D. He,et al. Gene expression profiling predicts clinical outcome of breast cancer , 2002, Nature.
[10] Gangning Liang,et al. Cooperativity between DNA Methyltransferases in the Maintenance Methylation of Repetitive Elements , 2002, Molecular and Cellular Biology.
[11] Rudolf Jaenisch,et al. Chromosomal silencing and localization are mediated by different domains of Xist RNA , 2002, Nature Genetics.
[12] Fabian Model,et al. Tumour class prediction and discovery by microarray-based DNA methylation analysis. , 2001, Nucleic acids research.
[13] Huidong Shi,et al. Methylation-specific oligonucleotide microarray: a new potential for high-throughput methylation analysis. , 2002, Genome research.
[14] A. Bird. DNA methylation patterns and epigenetic memory. , 2002, Genes & development.
[15] S. Piantadosi,et al. Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide. , 2001, Cancer research.
[16] J. Herman,et al. DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. , 2001, Human molecular genetics.
[17] E. Selker,et al. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa , 2001, Nature.
[18] P. Jones,et al. Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation. , 2001, Nucleic acids research.
[19] Peter A. Jones,et al. Reduced Rates of Gene Loss, Gene Silencing, and Gene Mutation in Dnmt1-Deficient Embryonic Stem Cells , 2001, Molecular and Cellular Biology.
[20] L. Aaltonen,et al. Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. , 2001, Cancer research.
[21] M. Tang,et al. Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers. , 2001, Cancer research.
[22] D. Reinberg,et al. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. , 2001, Genes & development.
[23] S. Baylin,et al. Dnmt3a and Dnmt3b Are Transcriptional Repressors That Exhibit Unique Localization Properties to Heterochromatin* , 2001, The Journal of Biological Chemistry.
[24] Ken-ichi Noma,et al. Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries , 2001, Science.
[25] C. Allis,et al. Translating the Histone Code , 2001, Science.
[26] J. Herman,et al. Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. , 2001, Cancer research.
[27] G. Berx,et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. , 2001, Molecular cell.
[28] T. Kouzarides,et al. Dnmt3a binds deacetylases and is recruited by a sequence‐specific repressor to silence transcription , 2001, The EMBO journal.
[29] J. Minna,et al. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. , 2001, Journal of the National Cancer Institute.
[30] N. Ahuja,et al. Accelerated age-related CpG island methylation in ulcerative colitis. , 2001, Cancer research.
[31] A. Wolffe,et al. Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[32] J. Herman,et al. A gene hypermethylation profile of human cancer. , 2001, Cancer research.
[33] Brian D. Strahl,et al. Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly , 2001, Science.
[34] Andrew J. Bannister,et al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain , 2001, Nature.
[35] G. Almouzni,et al. Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases , 2001, Nature Cell Biology.
[36] W. Gerald,et al. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma , 2001, Nature.
[37] J. Sudbø,et al. Gene-expression profiles in hereditary breast cancer. , 2001, The New England journal of medicine.
[38] Matthew Tudor,et al. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation , 2001, Nature Genetics.
[39] J. Willis,et al. Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer , 2000, Nature Genetics.
[40] S. Baylin,et al. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci , 2000, Nature Genetics.
[41] Chun Xing Li,et al. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3 , 2000, Nature Genetics.
[42] Peter L. Jones,et al. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters , 2000, Nature Genetics.
[43] Shirley M. Tilghman,et al. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus , 2000, Nature.
[44] G. Felsenfeld,et al. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene , 2000, Nature.
[45] J. Herman,et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. , 2000, Cancer research.
[46] J. Herman,et al. CpG methylation is maintained in human cancer cells lacking DNMT1 , 2000, Nature.
[47] J. Herman,et al. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. , 2000, Journal of the National Cancer Institute.
[48] J. Herman,et al. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. , 2000, Trends in genetics : TIG.
[49] M. Caligiuri,et al. Aberrant CpG-island methylation has non-random and tumour-type–specific patterns , 2000, Nature Genetics.
[50] J. Herman,et al. Methylation Patterns of the E-cadherin 5′ CpG Island Are Unstable and Reflect the Dynamic, Heterogeneous Loss of E-cadherin Expression during Metastatic Progression* , 2000, The Journal of Biological Chemistry.
[51] J. Herman,et al. Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome , 2000, Oncogene.
[52] M. Tang,et al. Mutation hotspots and DNA methylation. , 2000, Current topics in microbiology and immunology.
[53] M. Lübbert,et al. DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action. , 2000, Current topics in microbiology and immunology.
[54] A. Knudson,et al. Chasing the cancer demon. , 2000, Annual review of genetics.
[55] Luke Hughes-Davies,et al. DNA methyltransferase Dnmt1 associates with histone deacetylase activity , 2000, Nature Genetics.
[56] B. Turner,et al. Duplication and Maintenance of Heterochromatin Domains , 1999, The Journal of cell biology.
[57] C. Wijmenga,et al. The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[58] A. Bird,et al. Methylation-Induced Repression— Belts, Braces, and Chromatin , 1999, Cell.
[59] S. Elgin,et al. Putting Boundaries on Silence , 1999, Cell.
[60] N. Tommerup,et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene , 1999, Nature.
[61] J. Herman,et al. hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis. , 1999, The American journal of pathology.
[62] D. Haber,et al. DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development , 1999, Cell.
[63] J. Herman,et al. In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[64] B. Stillman,et al. Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins. , 1999, Molecular cell.
[65] Peter A. Jones,et al. Roles of Cell Division and Gene Transcription in the Methylation of CpG Islands , 1999, Molecular and Cellular Biology.
[66] J. Herman,et al. p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing. , 1999, Blood.
[67] J. Issa,et al. Aging, DNA methylation and cancer. , 1999, Critical reviews in oncology/hematology.
[68] E. Ballestar,et al. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation , 1999, Nature Genetics.
[69] Paul Tempst,et al. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex , 1999, Nature Genetics.
[70] A. Marzo,et al. Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis. , 1999, Cancer research.
[71] Brian J. Reid,et al. Progressive Region-Specific De Novo Methylation of the p16 CpG Island in Primary Human Mammary Epithelial Cell Strains during Escape from M0 Growth Arrest , 1999, Molecular and Cellular Biology.
[72] S. Baylin,et al. Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. , 1999, Cancer research.
[73] T. Huang,et al. Methylation profiling of CpG islands in human breast cancer cells. , 1999, Human molecular genetics.
[74] J. Herman,et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. , 1999, Cancer research.
[75] M. Ehrlich,et al. Frequent hypomethylation in Wilms tumors of pericentromeric DNA in chromosomes 1 and 16. , 1999, Cancer genetics and cytogenetics.
[76] Peter A. Jones,et al. Cancer-epigenetics comes of age , 1999, Nature Genetics.
[77] T. Curran,et al. Role of DNA 5-methylcytosine transferase in cell transformation by fos. , 1999, Science.
[78] J. Herman,et al. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer , 1999, Nature Genetics.
[79] K. Robertson,et al. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. , 1999, Nucleic acids research.
[80] T. Kiyono,et al. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells , 1998, Nature.
[81] Rudolf Jaenisch,et al. DNA hypomethylation leads to elevated mutation rates , 1998, Nature.
[82] S. Baylin,et al. Infection with Human Immunodeficiency Virus Type 1 Upregulates DNA Methyltransferase, Resulting in De Novo Methylation of the Gamma Interferon (IFN-γ) Promoter and Subsequent Downregulation of IFN-γ Production , 1998, Molecular and Cellular Biology.
[83] J. Herman,et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[84] J. Strouboulis,et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription , 1998, Nature Genetics.
[85] K. Struhl. Histone acetylation and transcriptional regulatory mechanisms. , 1998, Genes & development.
[86] J. Herman,et al. Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia. , 1998, Cancer research.
[87] Stephen B. Baylin,et al. Mapping Patterns of CpG Island Methylation in Normal and Neoplastic Cells Implicates Both Upstream and Downstream Regions inde Novo Methylation* , 1997, The Journal of Biological Chemistry.
[88] T. Bestor,et al. Formation of methylation patterns in the mammalian genome. , 1997, Mutation research.
[89] M. Loda,et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. , 1997, Cancer research.
[90] J. Herman,et al. Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. , 1997, Cancer research.
[91] Stefan U Kass,et al. DNA methylation directs a time-dependent repression of transcription initiation , 1997, Current Biology.
[92] G. Liang,et al. Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR. , 1997, Cancer research.
[93] R. Jaenisch,et al. DNA hypomethylation can activate Xist expression and silence X-linked genes. , 1996, Genes & development.
[94] L D Greller,et al. Tumor heterogeneity and progression: conceptual foundations for modeling. , 1996, Invasion & metastasis.
[95] S. Baylin,et al. p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3 , 1995, Nature Genetics.
[96] R. Weinberg,et al. Suppression of intestinal neoplasia by DNA hypomethylation , 1995, Cell.
[97] M. Mareel,et al. Cancer metastasis: negative regulation by an invasion-suppressor complex. , 1995, Cancer detection and prevention.
[98] J. Herman,et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[99] P. Jones,et al. Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer , 1994, Molecular and cellular biology.
[100] S. Baylin,et al. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon , 1994, Nature Genetics.
[101] J. Herman,et al. Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[102] I. Fidler. The biology of cancer metastasis or, 'you cannot fix it if you do not know how it works'. , 1991, BioEssays : news and reviews in molecular, cellular and developmental biology.
[103] G. Coetzee,et al. 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. , 1990, Science.
[104] A. Feinberg,et al. Reduced genomic 5-methylcytosine content in human colonic neoplasia. , 1988, Cancer research.
[105] R. Jaenisch,et al. Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[106] A. Feinberg,et al. Hypomethylation distinguishes genes of some human cancers from their normal counterparts , 1983, Nature.
[107] B. Migeon,et al. Studies of X chromosome DNA methylation in normal human cells , 1982, Nature.
[108] T. Mohandas,et al. Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation. , 1981, Science.
[109] Peter A. Jones,et al. Cellular differentiation, cytidine analogs and DNA methylation , 1980, Cell.
[110] Philip J. Farabaugh,et al. Molecular basis of base substitution hotspots in Escherichia coli , 1978, Nature.
[111] Cancer: Science and Society , 1978 .
[112] A. Čihák. Biological effects of 5-azacytidine in eukaryotes. , 1974, Oncology.