Receptor-Mediated Pathways That Modulate Calcium Channels ☆

Abstract Voltage-dependent Ca 2+ channels are ubiquitous regulators of Ca 2+ -dependent cellular functions. In light of this, it is perhaps not surprising that nature has devised a complex web of G protein-coupled regulatory pathways that appear to tune Ca 2+ channel function appropriately for given physiological demands. We are beginning to identify the molecular components of these pathways and to discover ways of altering them experimentally. Ultimately, it is likely that unique features of each pathway can be exploited to evaluate the physiological roles they play and to determine how they interact with one another as well as with other signaling pathways in cells.

[1]  R. Neubig,et al.  Novel form of crosstalk between G protein and tyrosine kinase pathways. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[2]  M. Serafin,et al.  Facilitation of N-Type Calcium Current Is Dependent on the Frequency of Action Potential-Like Depolarizations in Dissociated Cholinergic Basal Forebrain Neurons of the Guinea Pig , 1997, The Journal of Neuroscience.

[3]  K. Page,et al.  The Intracellular Loop between Domains I and II of the B-Type Calcium Channel Confers Aspects of G-Protein Sensitivity to the E-Type Calcium Channel , 1997, The Journal of Neuroscience.

[4]  T. Snutch,et al.  Crosstalk between G proteins and protein kinase C mediated by the calcium channel α1 subunit , 1997, Nature.

[5]  Denise S Walker,et al.  Direct binding of G-protein βλ complex to voltage-dependent calcium channels , 1997, Nature.

[6]  K. Weiss,et al.  Functional consequences of divergence and convergence in physiological signaling pathways , 1997, Molecular Psychiatry.

[7]  G. Schultz,et al.  Specificity of interaction between receptor and G protein: use of antisense techniques to relate G-protein subunits to function. , 1996, Biochimica et biophysica acta.

[8]  R. Tsien,et al.  Multiple Structural Elements in Voltage-Dependent Ca2+ Channels Support Their Inhibition by G Proteins , 1996, Neuron.

[9]  I. V. Orekhova,et al.  Functional Uncoupling of Linked Neurotransmitter Effects by Combinatorial Convergence , 1996, Science.

[10]  S. Ikeda.  Voltage-dependent modulation of N-type calcium channels by G-protein β γsubunits , 1996, Nature.

[11]  WG Regehr,et al.  Contributions of calcium-dependent and calcium-independent mechanisms to presynaptic inhibition at a cerebellar synapse , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[12]  K. Mackie,et al.  Modulation of Ca2+ channels βγ G-protein py subunits , 1996, Nature.

[13]  D. Clapham,et al.  Ion channel regulation by G proteins. , 1995, Physiological reviews.

[14]  S. Treistman,et al.  Abolition of G protein inhibition of α 1A and α 1B calcium channels by co‐expression of the β 3 subunit , 1995 .

[15]  P. Saggau,et al.  GABAB receptor‐mediated presynaptic inhibition in guinea‐pig hippocampus is caused by reduction of presynaptic Ca2+ influx. , 1995, The Journal of physiology.

[16]  K. Brickley,et al.  Inhibition of the interaction of G protein G(o) with calcium channels by the calcium channel beta‐subunit in rat neurones. , 1995, The Journal of physiology.

[17]  K. Campbell,et al.  Properties of the - Anchoring Site in Voltage-dependent Ca Channels (*) , 1995, The Journal of Biological Chemistry.

[18]  R. Miller,et al.  Calcium and sodium currents evoked by action potential waveforms in rat sympathetic neurones. , 1995, The Journal of physiology.

[19]  J. Luebke,et al.  Exocytotic Ca2+ channels in mammalian central neurons , 1995, Trends in Neurosciences.

[20]  G. Schofield,et al.  Nitric oxide donors enhanced Ca2+ currents and blocked noradrenaline‐induced Ca2+ current inhibition in rat sympathetic neurons. , 1995, The Journal of physiology.

[21]  Bertil Hille,et al.  Modulation of ion-channel function by G-protein-coupled receptors , 1994, Trends in Neurosciences.

[22]  T. Schneider,et al.  Calcium channels: Structure, function, and classification , 1994 .

[23]  S. Ikeda,et al.  Modulation of Ca(2+)-channel currents by protein kinase C in adult rat sympathetic neurons. , 1994, Journal of neurophysiology.

[24]  S. Ikeda,et al.  VIP inhibits N-type Ca2+ channels of sympathetic neurons via a pertussis toxin-insensitive but cholera toxin-sensitive pathway , 1994, Neuron.

[25]  D. A. Brown,et al.  Muscarinic M‐current inhibition via G alpha q/11 and alpha‐adrenoceptor inhibition of Ca2+ current via G alpha o in rat sympathetic neurones. , 1994, The Journal of physiology.

[26]  Lori L. Isom,et al.  Auxiliary subunits of voltage-gated ion channels , 1994, Neuron.

[27]  S. D. Meriney,et al.  Somatostatin-induced inhibition of neuronal Ca2+ current modulated by cGMP-dependent protein kinase , 1994, Nature.

[28]  Peter Saggau,et al.  Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus , 1994, Neuron.

[29]  K. Campbell,et al.  Calcium channel β-subunit binds to a conserved motif in the I–II cytoplasmic linker of the α1-subunit , 1994, Nature.

[30]  M. Adams,et al.  Toxityping rat brain calcium channels with omega-toxins from spider and cone snail venoms. , 1993, Biochemistry.

[31]  Mark E. Williams,et al.  Human neuronal voltage-dependent calcium channels: Studies on subunit structure and role in channel assembly , 1993, Neuropharmacology.

[32]  N. Berrow,et al.  GABAB receptor modulation of Ca2+ currents in rat sensory neurones by the G protein G(0): antisense oligonucleotide studies. , 1993, The Journal of physiology.

[33]  S. Siegelbaum,et al.  Kinetic basis for the voltage-dependent inhibition of N-type calcium current by somatostatin and norepinephrine in chick sympathetic neurons , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[34]  V. Bindokas,et al.  Mechanism of presynaptic inhibition by neuropeptide Y at sympathetic nerve terminals , 1993, Nature.

[35]  K. Swartz,et al.  Modulation of Ca2+ channels by protein kinase C in rat central and peripheral neurons: Disruption of G protein-mediated inhibition , 1993, Neuron.

[36]  K. Campbell,et al.  Subunit identification and reconstitution of the N-type Ca2+ channel complex purified from brain. , 1993, Science.

[37]  M. Diversé-Pierluissi,et al.  Distinct, convergent second messenger pathways modulate neuronal calcium currents , 1993, Neuron.

[38]  R. Tsien,et al.  Enhancement of N- and L-type calcium channel currents by protein kinase C in frog sympathetic neurons , 1993, Neuron.

[39]  LM Boland,et al.  Modulation of N-type calcium channels in bullfrog sympathetic neurons by luteinizing hormone-releasing hormone: kinetics and voltage dependence , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[40]  B. Hille,et al.  Substance P and somatostatin inhibit calcium channels in rat sympathetic neurons via different G protein pathwavs , 1993, Neuron.

[41]  D. Lovinger,et al.  Protein kinase C modulates glutamate receptor inhibition of Ca2+ channels and synaptic transmission , 1993, Nature.

[42]  J. Boyer,et al.  Beta gamma-subunit activation of G-protein-regulated phospholipase C. , 1992, The Journal of biological chemistry.

[43]  G. Schofield,et al.  Norepinephrine-induced Ca2+ current inhibition in adult rat sympathetic neurons does not require protein kinase C activation. , 1992, European journal of pharmacology.

[44]  Richard J. Miller,et al.  Inhibition of quantal transmitter release in the absence of calcium influx by a G protein-linked adenosine receptor at hippocampal synapses , 1992, Neuron.

[45]  D. H. Cox,et al.  Pharmacological discrimination of N-type from L-type calcium current and its selective modulation by transmitters , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[46]  J S Kelly,et al.  A study of the mechanism of Ca2+ current inhibition produced by serotonin in rat dorsal raphe neurons , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[47]  M. Biel,et al.  The roles of the subunits in the function of the calcium channel. , 1991, Science.

[48]  G. Schultz,et al.  Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents , 1991, Nature.

[49]  A. Rittenhouse,et al.  Neurotransmitter modulation of calcium channels in rat sympathetic neurons , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[50]  B. Hille,et al.  A diffusible second messenger mediates one of the pathways coupling receptors to calcium channels in rat sympathetic neurons , 1991, Neuron.

[51]  S. W. Jones,et al.  LHRH and GTP-γ-S modify calcium current activation in bullfrog sympathetic neurons , 1990, Neuron.

[52]  D. Sah,et al.  Neurotransmitter modulation of calcium current in rat spinal cord neurons , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[53]  H. Lux,et al.  Voltage-dependent GABA-induced modulation of calcium currents in chick sensory neurons , 1989, Neuroscience Letters.

[54]  K. Lukowiak,et al.  A neuromodulator of synaptic transmission acts on the secretory apparatus as well as on ion channels , 1989, Nature.

[55]  D. A. Brown,et al.  Antibodies to the GTP binding protein, Go, antagonize noradrenaline-induced calcium current inhibition in NG108-15 hybrid cells , 1989, Neuron.

[56]  J. McDonald,et al.  Specific inhibitors of protein kinase C block transmitter-induced modulation of sensory neuron calcium current , 1989, Neuron.

[57]  B. Bean.  Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence , 1989, Nature.

[58]  D. Logothetis,et al.  Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons , 1989, Neuron.

[59]  P. Sternweis,et al.  Differential G protein—mediated coupling of neurotransmitter receptors to Ca2+ channels in rat dorsal root ganglion neurons in vitro , 1989, Neuron.

[60]  G. Schultz,et al.  The GTP-binding protein, Go9 regulates neuronal calcium channels , 1987, Nature.

[61]  D. Schulz,et al.  Noradrenaline modulates calcium channels in avian dorsal root ganglion cells through tight receptor‐channel coupling. , 1986, The Journal of physiology.

[62]  P. Adams,et al.  Control of calcium current in rat sympathetic neurons by norepinephrine , 1982, Brain Research.

[63]  G. Fischbach,et al.  Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neurones. , 1981, The Journal of physiology.

[64]  S. Ikeda,et al.  Voltage-dependent modulation of N-type calcium channels: role of G protein subunits. , 1999, Advances in second messenger and phosphoprotein research.

[65]  A. Dolphin.  The G.L. Brown Prize Lecture. Voltage‐dependent calcium channels and their modulation by neurotransmitters and G proteins , 1995, Experimental physiology.

[66]  P. Goldsmith,et al.  Transmitter-mediated inhibition of N-type calcium channels in sensory neurons involves multiple GTP-binding proteins and subunits , 1995, Neuron.

[67]  W. Catterall.  Structure and function of voltage-gated ion channels. , 1995, Annual review of biochemistry.

[68]  M. Biel,et al.  Molecular basis for Ca2+ channel diversity. , 1994, Annual review of neuroscience.

[69]  H. C. Hartzell,et al.  Direct regulation of cardiac Ca2+ channels by G proteins: neither proven nor necessary? , 1992, Trends in pharmacological sciences.

[70]  K. Dunlap,et al.  CHAPTER 15 – G Protein- and Protein Kinase C-Mediated Regulation of Voltage-Dependent Calcium Channels , 1990 .

[71]  A. Brown,et al.  Ionic channels and their regulation by G protein subunits. , 1990, Annual review of physiology.

[72]  B. L. Ginsborg,et al.  Modulation of neurotransmitter release by adenosine and ATP. , 1987, Progress in clinical and biological research.

[73]  H. Reuter,et al.  The regulation of the calcium conductance of cardiac muscle by adrenaline. , 1977, The Journal of physiology.