Vitamin E Treatment Enhances Erythrocyte Deformability in Aged Rats (aging/haemorheology/redbloodcellaggregation/redbloodcelldeformability/oxidativestress)

The harmful effects of aging on blood rhe- ology have been well known. These effects in the ag- ing have been found to be associated with an increase in oxidative stress. The aim of this study was to seek whether treatment of vitamin E as a potent antioxi- dant could improve the age-related haemorheologi- cal abnormalities. For this purpose, male Wistar rats at the age of 3 and 24 months were used. The follow- ing parameters were evaluated: red blood cell (RBC) deformability, aggregation, plasma viscosity, vitamin E level, total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI), and the following results were obtained. First, aging was associated with a decrease in RBC deformability and increase in RBC aggregation and plasma viscosity. Second, compared with the young group, while plas- ma TOS levels and OSI were found to be significant- ly increased in aged rats, there was no significant change in their plasma TAS level. Third, vitamin E administration produced significant improvement in RBC deformability and decrement in TOS and OSI values in aged rats with respect to young and aged control groups. We did not find any significant effect of vitamin E treatment on RBC aggregation in both young and aged rats and finally, we found a signifi-

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