The pattern of breathing following step changes of alveolar partial pressures of carbon dioxide and oxygen in man

1. The pattern of breathing during the approach to the steady state following step changes of end‐tidal PCO2 and PO2 has been determined in normal conscious human subjects. Three types of step were studied: (a) steps of PA, CO2 against a constant background of hyperoxia (PA, O2 ∼ 200), an almost pure intracranial chemoreceptor stimulus, (b) steps of PA, O2 between ∼ 50 and 80 torr against a background of constant mild hypercapnia, an arterial chemoreceptor stimulus, and (c) steps of PA, CO2 against a background of constant hypoxia (PA, O2 ∼ 50), a mixed stimulus. Steps were small and the responses barely detectable by the subjects.

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