APOLIPOPROTEIN E4 POLYMORPHISM AS RISK FACTOR FOR CORONARY HEART DISEASE AMONG

Apolipoprotein E genotypes and lipid and lipoprotein levels were determined in hypercholesterolemic and angiographically vertified CHD subjects and compared against 90 normolipidemic controls. The ~4 allele was significantly prevalent in the hypercholesterolemic and CHD subjects. Significant increase in total cholesterol levels in apo ~4 containing subjects were observed in the hypercholesterolemic and CHD group. The study suggests that the ~4 allele by influencing the lipid levels could act as a risk factor for CHD.

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