Neue Verfahren in der Leberersatztherapie*

Zusammenfassung.Das Leberversagen weist trotz der Möglichkeiten der Lebertransplantation nach wie vor eine hohe Mortalität auf. Durch den Einsatz von Leberersatzverfahren soll das akute Stadium der Leberinsuffizienz besser überbrückt werden. Eine Vielzahl an maschinellen und bioartifiziellen Verfahren sowie die Hepatozytentransplantation befinden sich bereits in der klinischen Erprobung. Allerdings sind bisher nur wenig kontrollierte Daten verfügbar, die den möglichen Einfluss auf das Patientenüberleben untersucht haben. Daher wird momentan nur der Einsatz innerhalb klinischer Studien an spezialisierten Zentren empfohlen.Abstract.Despite the possibilities of liver transplantation, liver failure is still associated with a high mortality rate. Liver replacement therapies have been developed to bridge the acute decompensation of liver function. A variety of artificial and bioartificial devices as well as hepatocyte transplantation are already tested in clinical settings. To date, few controlled data are available, especially with regard to patient survival. Therefore, liver replacement therapy should only be used in clinical studies at specialized centers.

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